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MATK  -  megakaryocyte-associated tyrosine kinase

Homo sapiens

Synonyms: CHK, CSK homologous kinase, CTK, DKFZp434N1212, HHYLTK, ...
 
 
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Disease relevance of MATK

  • Association of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells [1].
  • Compared to YM subjects, MATK runners had higher resting heart rates and lower treadmill performance times, and compared to both groups of marathoners, MATK runners had lower VO2max, but only when expressed relative to body weight [2].
  • Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors [3].
  • In addition, CHK overexpression in neuroblastoma and astrocytoma cells inhibited their growth and proliferation [3].
  • CHK overexpression in primary hippocampal neurons using recombinant adenovirus infection resulted both in increased CHK kinase activity and changes in neuronal morphology [3].
 

High impact information on MATK

  • We evaluated a list of high-yield criteria (HYL) as a means of reducing posttraumatic skull roentgenograms and as a diagnostic test for skull fractures [4].
  • Here we have examined the expression and regulation of Lsk and Csk in peripheral human monocytes [5].
  • Unlike Csk that is ubiquitously expressed, Lsk has limited tissue distribution [5].
  • To prevent constitutive SFK activation, the catalytic activity of SFKs in normal mammalian cells is suppressed mainly by two inhibitors called C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK), which inactivate SFKs by phosphorylating a consensus tyrosine near the C terminus of SFKs (Y(T)) [6].
  • C-terminal Src Kinase-homologous Kinase (CHK), a Unique Inhibitor Inactivating Multiple Active Conformations of Src Family Tyrosine Kinases [6].
 

Chemical compound and disease context of MATK

 

Biological context of MATK

 

Anatomical context of MATK

  • Antisense oligonucleotides directed against MATK mRNA sequences significantly inhibited megakaryocyte progenitor proliferation [8].
  • The expression of HYL was upregulated when these myeloid cells were differentiated by induction with phorbol myristate acetate [9].
  • These findings establish close relationship between the HYL and CSK genes and also suggest that HYL may play an important role in signal transduction through SRC-family kinases in the central nervous system [10].
  • Using PC12 cells as a model system of neuronal cells, we show that CHK participates in signaling mediated by TrkA receptors [11].
  • Thus, CHK is a novel signaling molecule that participates in TrkA signaling, associates directly with TrkA receptors upon NGF stimulation, and is involved in neurite outgrowth of PC12 cells in response to NGF [11].
 

Associations of MATK with chemical compounds

  • Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product [8].
  • The mouse HYL gene was assigned to the R-positive C1 band of chromosome 10 by fluorescent in situ hybridization [10].
  • Sequence comparisons also indicate that matk contains src homology region 2 and 3 domains but lacks the NH2-terminal myristylation signal, the negative regulatory tyrosine (Tyr-527), and the autophosphorylation site (Tyr-416) corresponding to those found in src [12].
  • Binding assays and far Western blotting analysis, using glutathione S-transferase fusion proteins containing the Src homology 2 (SH2) and SH3 domains of CHK, demonstrate that the SH2 domain of CHK binds directly to the tyrosine-phosphorylated TrkA receptors [11].
  • Responses of ABA and CTK to soil drought in leafless and leafy apple tree [13].
 

Regulatory relationships of MATK

  • Since activation of RAFTK is associated with the activity of Src family kinases, we analyzed whether CHK is capable of opposing HRG-induced activation of RAFTK [7].
 

Other interactions of MATK

 

Analytical, diagnostic and therapeutic context of MATK

References

  1. Association of csk-homologous kinase (CHK) (formerly MATK) with HER-2/ErbB-2 in breast cancer cells. Zrihan-Licht, S., Lim, J., Keydar, I., Sliwkowski, M.X., Groopman, J.E., Avraham, H. J. Biol. Chem. (1997) [Pubmed]
  2. Comparative physiological profiles among young and middle-aged female distance runners. Upton, S.J., Hagan, R.D., Lease, B., Rosentswieg, J., Gettman, L.R., Duncan, J.J. Medicine and science in sports and exercise. (1984) [Pubmed]
  3. Differential expression of Csk homologous kinase (CHK) in normal brain and brain tumors. Kim, S.O., Avraham, S., Jiang, S., Zagozdzon, R., Fu, Y., Avraham, H.K. Cancer (2004) [Pubmed]
  4. High-yield referral criteria for posttraumatic skull roentgenography. Response of physicians and accuracy of criteria. Cummins, R.O., LoGerfo, J.P., Inui, T.S., Weiss, N.S. JAMA (1980) [Pubmed]
  5. IL-4 and IL-13 induce Lsk, a Csk-like tyrosine kinase, in human monocytes. Musso, T., Varesio, L., Zhang, X., Rowe, T.K., Ferrara, P., Ortaldo, J.R., O'Shea, J.J., McVicar, D.W. J. Exp. Med. (1994) [Pubmed]
  6. C-terminal Src Kinase-homologous Kinase (CHK), a Unique Inhibitor Inactivating Multiple Active Conformations of Src Family Tyrosine Kinases. Chong, Y.P., Chan, A.S., Chan, K.C., Williamson, N.A., Lerner, E.C., Smithgall, T.E., Bjorge, J.D., Fujita, D.J., Purcell, A.W., Scholz, G., Mulhern, T.D., Cheng, H.C. J. Biol. Chem. (2006) [Pubmed]
  7. Csk homologous kinase associates with RAFTK/Pyk2 in breast cancer cells and negatively regulates its activation and breast cancer cell migration. McShan, G.D., Zagozdzon, R., Park, S.Y., Zrihan-Licht, S., Fu, Y., Avraham, S., Avraham, H. Int. J. Oncol. (2002) [Pubmed]
  8. Structural and functional studies of the intracellular tyrosine kinase MATK gene and its translated product. Avraham, S., Jiang, S., Ota, S., Fu, Y., Deng, B., Dowler, L.L., White, R.A., Avraham, H. J. Biol. Chem. (1995) [Pubmed]
  9. Molecular cloning of a novel non-receptor tyrosine kinase, HYL (hematopoietic consensus tyrosine-lacking kinase). Sakano, S., Iwama, A., Inazawa, J., Ariyama, T., Ohno, M., Suda, T. Oncogene (1994) [Pubmed]
  10. Characterization of mouse non-receptor tyrosine kinase gene, HYL. Hamaguchi, I., Iwama, A., Yamaguchi, N., Sakano, S., Matsuda, Y., Suda, T. Oncogene (1994) [Pubmed]
  11. The Csk homologous kinase associates with TrkA receptors and is involved in neurite outgrowth of PC12 cells. Yamashita, H., Avraham, S., Jiang, S., Dikic, I., Avraham, H. J. Biol. Chem. (1999) [Pubmed]
  12. Identification and characterization of a novel tyrosine kinase from megakaryocytes. Bennett, B.D., Cowley, S., Jiang, S., London, R., Deng, B., Grabarek, J., Groopman, J.E., Goeddel, D.V., Avraham, H. J. Biol. Chem. (1994) [Pubmed]
  13. Responses of ABA and CTK to soil drought in leafless and leafy apple tree. Li, Y., Pan, H.C., Li, D.Q. J. Zhejiang Univ. Sci. (2003) [Pubmed]
  14. The MATK tyrosine kinase interacts in a specific and SH2-dependent manner with c-Kit. Jhun, B.H., Rivnay, B., Price, D., Avraham, H. J. Biol. Chem. (1995) [Pubmed]
  15. Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer. Kim, S., Zagozdzon, R., Meisler, A., Baleja, J.D., Fu, Y., Avraham, S., Avraham, H. J. Biol. Chem. (2002) [Pubmed]
  16. The Csk-like proteins Lsk, Hyl, and Matk represent the same Csk homologous kinase (Chk) and are regulated by stem cell factor in the megakaryoblastic cell line MO7e. Grgurevich, S., Linnekin, D., Musso, T., Zhang, X., Modi, W., Varesio, L., Ruscetti, F.W., Ortaldo, J.R., McVicar, D.W. Growth Factors (1997) [Pubmed]
  17. Hyperprolactinemia due to big big prolactin is differently detected by commercially available immunoassays. Cavaco, B., Prazeres, S., Santos, M.A., Sobrinho, L.G., Leite, V. J. Endocrinol. Invest. (1999) [Pubmed]
 
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