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Gene Review

E2F6  -  E2F transcription factor 6

Homo sapiens

Synonyms: E2F-6, Transcription factor E2F6
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Disease relevance of E2F6


High impact information on E2F6

  • Mapping studies indicate that RYBP binds within the known "repression domain" of E2F6 [4].
  • The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex [4].
  • Taken together, these data suggest that E2F-6 can regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression [5].
  • E2F-6 lacks pocket protein binding and transactivation domains, and it is a potent transcriptional repressor that contains a modular repression domain at its carboxyl terminus [5].
  • Overproduction of E2F-6 had no specific effect on cell cycle progression in asynchronously growing Saos2 and NIH 3T3 cells, but it inhibited entry into S phase of NIH 3T3 cells stimulated to exit G0 [5].

Biological context of E2F6


Anatomical context of E2F6

  • In this study, we examined the ability of E2F6 to act as the molecular switch required for E2F inhibition in order for keratinocytes to enter a terminal differentiation programme [1].
  • Investigation of the relationship between E2F6 and RING1 by immunofluorescence and confocal analysis, in HL cell lines and paraffin sections, revealed co-expression of both proteins in the same tumour cells [2].
  • To better elucidate the molecular mechanism of repression by E2F-6, we have purified the factor from cultured cells [3].

Associations of E2F6 with chemical compounds

  • However, we found that the E2F6-regulated promoters did not contain histone H3 methylated at lysine 9 [6].

Physical interactions of E2F6

  • E2F6 contains a DNA binding domain that is very similar to that of the other members of the E2F family of transcriptional regulators [6].

Other interactions of E2F6

  • However, E2F6 cannot bind to all promoters that contain consensus E2F-binding sites [6].
  • We report the isolation of RYBP, a recently identified member of the mammalian polycomb complex, as an E2F6-interacting protein [4].
  • The cell cycle proteins associated with these tumors were E2F6, cyclins A, B1 and E, SKP2 and Topo IIalpha [9].

Analytical, diagnostic and therapeutic context of E2F6


  1. E2F6: a member of the E2F family that does not modulate squamous differentiation. Wong, C.F., Barnes, L.M., Smith, L., Popa, C., Serewko-Auret, M.M., Saunders, N.A. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  2. Abnormal PcG protein expression in Hodgkin's lymphoma. Relation with E2F6 and NFkappaB transcription factors. Sánchez-Beato, M., Sánchez, E., García, J.F., Pérez-Rosado, A., Montoya, M.C., Fraga, M., Artiga, M.J., Navarrete, M., Abraira, V., Morente, M., Esteller, M., Koseki, H., Vidal, M., Piris, M.A. J. Pathol. (2004) [Pubmed]
  3. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Ogawa, H., Ishiguro, K., Gaubatz, S., Livingston, D.M., Nakatani, Y. Science (2002) [Pubmed]
  4. The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Trimarchi, J.M., Fairchild, B., Wen, J., Lees, J.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Unusual proliferation arrest and transcriptional control properties of a newly discovered E2F family member, E2F-6. Gaubatz, S., Wood, J.G., Livingston, D.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  6. E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9. Oberley, M.J., Inman, D.R., Farnham, P.J. J. Biol. Chem. (2003) [Pubmed]
  7. Activity of the human cytochrome c1 promoter is modulated by E2F. Luciakova, K., Barath, P., Li, R., Zaid, A., Nelson, B.D. Biochem. J. (2000) [Pubmed]
  8. Activating E2Fs mediate transcriptional regulation of human E2F6 repressor. Lyons, T.E., Salih, M., Tuana, B.S. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  9. Phenotypic characterization of BRCA1 and BRCA2 tumors based in a tissue microarray study with 37 immunohistochemical markers. Palacios, J., Honrado, E., Osorio, A., Cazorla, A., Sarrió, D., Barroso, A., Rodríguez, S., Cigudosa, J.C., Diez, O., Alonso, C., Lerma, E., Dopazo, J., Rivas, C., Benítez, J. Breast Cancer Res. Treat. (2005) [Pubmed]
  10. Arabidopsis E2F1 binds a sequence present in the promoter of S-phase-regulated gene AtCDC6 and is a member of a multigene family with differential activities. de Jager, S.M., Menges, M., Bauer, U.M., Murra, J.A. Plant Mol. Biol. (2001) [Pubmed]
  11. Transforming growth factor-beta1-regulated proteins in human endothelial cells identified by two-dimensional gel electrophoresis and mass spectrometry. Lomnytska, M., Lukiyanchuk, V., Hellman, U., Souchelnytskyi, S. Proteomics (2004) [Pubmed]
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