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Gene Review

Ppargc1a  -  peroxisome proliferative activated...

Mus musculus

Synonyms: A830037N07Rik, ENSMUSG00000079510, Gm11133, PGC-1, PGC-1-alpha, ...
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Disease relevance of Ppargc1a


Psychiatry related information on Ppargc1a


High impact information on Ppargc1a


Chemical compound and disease context of Ppargc1a


Biological context of Ppargc1a


Anatomical context of Ppargc1a

  • The expression of Ppargc1a and Nrf1 was also stimulated by n-3 polyunsaturated fatty acids in 3T3-L1 cells [16].
  • The nuclear hormone receptor coactivator PGC-1 (peroxisome proliferator-activated (PPAR)-gamma coactivator-1) has been implicated in the onset of type 2 diabetes [1].
  • We conclude that ERRalpha serves as a critical nodal point in the regulatory circuitry downstream of PGC-1alpha to direct the transcription of genes involved in mitochondrial energy-producing pathways in cardiac and skeletal muscle [15].
  • Regulation of the PGC-1alpha gene and that of mitochondrial 3-hydroxy-3-methyl-glutaryl-coenzyme A synthase, acyl-coenzyme A oxidase, and long-chain acyl-coenzyme dehydrogenase, marker genes of lipid catabolism, were dissociated in fetuses and neonates [17].
  • The control of UCP1 is dissociated from that of PGC-1alpha or of mitochondriogenesis as revealed by a study using beta-less mouse brown adipocytes in culture [18].

Associations of Ppargc1a with chemical compounds


Physical interactions of Ppargc1a


Enzymatic interactions of Ppargc1a


Regulatory relationships of Ppargc1a


Other interactions of Ppargc1a


Analytical, diagnostic and therapeutic context of Ppargc1a


  1. PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3. Koo, S.H., Satoh, H., Herzig, S., Lee, C.H., Hedrick, S., Kulkarni, R., Evans, R.M., Olefsky, J., Montminy, M. Nat. Med. (2004) [Pubmed]
  2. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Wang, L., Liu, J., Saha, P., Huang, J., Chan, L., Spiegelman, B., Moore, D.D. Cell metabolism. (2005) [Pubmed]
  3. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Handschin, C., Lin, J., Rhee, J., Peyer, A.K., Chin, S., Wu, P.H., Meyer, U.A., Spiegelman, B.M. Cell (2005) [Pubmed]
  4. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. Lehman, J.J., Barger, P.M., Kovacs, A., Saffitz, J.E., Medeiros, D.M., Kelly, D.P. J. Clin. Invest. (2000) [Pubmed]
  5. Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration. Weydt, P., Pineda, V.V., Torrence, A.E., Libby, R.T., Satterfield, T.F., Lazarowski, E.R., Gilbert, M.L., Morton, G.J., Bammler, T.K., Strand, A.D., Cui, L., Beyer, R.P., Easley, C.N., Smith, A.C., Krainc, D., Luquet, S., Sweet, I.R., Schwartz, M.W., La Spada, A.R. Cell metabolism (2006) [Pubmed]
  6. PGC-1alpha genotype modifies the association of volitional energy expenditure with [OV0312]O2max. Franks, P.W., Barroso, I., Luan, J., Ekelund, U., Crowley, V.E., Brage, S., Sandhu, M.S., Jakes, R.W., Middelberg, R.P., Harding, A.H., Schafer, A.J., O'Rahilly, S., Wareham, N.J. Medicine and science in sports and exercise. (2003) [Pubmed]
  7. In vino veritas: a tale of two sirt1s? Koo, S.H., Montminy, M. Cell (2006) [Pubmed]
  8. Transcriptional Repression of PGC-1alpha by Mutant Huntingtin Leads to Mitochondrial Dysfunction and Neurodegeneration. Cui, L., Jeong, H., Borovecki, F., Parkhurst, C.N., Tanese, N., Krainc, D. Cell (2006) [Pubmed]
  9. Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators. St-Pierre, J., Drori, S., Uldry, M., Silvaggi, J.M., Rhee, J., J??ger, S., Handschin, C., Zheng, K., Lin, J., Yang, W., Simon, D.K., Bachoo, R., Spiegelman, B.M. Cell (2006) [Pubmed]
  10. Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. Rhee, J., Ge, H., Yang, W., Fan, M., Handschin, C., Cooper, M., Lin, J., Li, C., Spiegelman, B.M. J. Biol. Chem. (2006) [Pubmed]
  11. Alterations of PPARalpha and its coactivator PGC-1 in cisplatin-induced acute renal failure. Portilla, D., Dai, G., McClure, T., Bates, L., Kurten, R., Megyesi, J., Price, P., Li, S. Kidney Int. (2002) [Pubmed]
  12. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1alpha. Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., Geny, B., Laakso, M., Puigserver, P., Auwerx, J. Cell (2006) [Pubmed]
  13. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Herzig, S., Long, F., Jhala, U.S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., Spiegelman, B., Montminy, M. Nature (2001) [Pubmed]
  14. Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9. Kawakami, Y., Tsuda, M., Takahashi, S., Taniguchi, N., Esteban, C.R., Zemmyo, M., Furumatsu, T., Lotz, M., Belmonte, J.C., Asahara, H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  15. Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Huss, J.M., Torra, I.P., Staels, B., Giguère, V., Kelly, D.P. Mol. Cell. Biol. (2004) [Pubmed]
  16. Polyunsaturated fatty acids of marine origin upregulate mitochondrial biogenesis and induce beta-oxidation in white fat. Flachs, P., Horakova, O., Brauner, P., Rossmeisl, M., Pecina, P., Franssen-van Hal, N., Ruzickova, J., Sponarova, J., Drahota, Z., Vlcek, C., Keijer, J., Houstek, J., Kopecky, J. Diabetologia (2005) [Pubmed]
  17. The developmental regulation of peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression in the liver is partially dissociated from the control of gluconeogenesis and lipid catabolism. Yubero, P., Hondares, E., Carmona, M.C., Rossell, M., Gonzalez, F.J., Iglesias, R., Giralt, M., Villarroya, F. Endocrinology (2004) [Pubmed]
  18. The control of UCP1 is dissociated from that of PGC-1alpha or of mitochondriogenesis as revealed by a study using beta-less mouse brown adipocytes in culture. Lehr, L., Canola, K., Asensio, C., Jimenez, M., Kuehne, F., Giacobino, J.P., Muzzin, P. FEBS Lett. (2006) [Pubmed]
  19. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Vega, R.B., Huss, J.M., Kelly, D.P. Mol. Cell. Biol. (2000) [Pubmed]
  20. Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Arany, Z., Novikov, M., Chin, S., Ma, Y., Rosenzweig, A., Spiegelman, B.M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  21. Thiazolidinediones and rexinoids induce peroxisome proliferator-activated receptor-coactivator (PGC)-1alpha gene transcription: an autoregulatory loop controls PGC-1alpha expression in adipocytes via peroxisome proliferator-activated receptor-gamma coactivation. Hondares, E., Mora, O., Yubero, P., de la Concepción, M.R., Iglesias, R., Giralt, M., Villarroya, F. Endocrinology (2006) [Pubmed]
  22. Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Cooper, M.P., Qu, L., Rohas, L.M., Lin, J., Yang, W., Erdjument-Bromage, H., Tempst, P., Spiegelman, B.M. Genes Dev. (2006) [Pubmed]
  23. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. Handschin, C., Choi, C.S., Chin, S., Kim, S., Kawamori, D., Kurpad, A.J., Neubauer, N., Hu, J., Mootha, V.K., Kim, Y.B., Kulkarni, R.N., Shulman, G.I., Spiegelman, B.M. J. Clin. Invest. (2007) [Pubmed]
  24. A role for the transcriptional coactivator PGC-1alpha in muscle refueling. Wende, A.R., Schaeffer, P.J., Parker, G.J., Zechner, C., Han, D.H., Chen, M.M., Hancock, C.R., Lehman, J.J., Huss, J.M., McClain, D.A., Holloszy, J.O., Kelly, D.P. J. Biol. Chem. (2007) [Pubmed]
  25. Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. Gerhart-Hines, Z., Rodgers, J.T., Bare, O., Lerin, C., Kim, S.H., Mostoslavsky, R., Alt, F.W., Wu, Z., Puigserver, P. EMBO J. (2007) [Pubmed]
  26. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Rhee, J., Inoue, Y., Yoon, J.C., Puigserver, P., Fan, M., Gonzalez, F.J., Spiegelman, B.M. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  27. Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha. Scimè, A., Grenier, G., Huh, M.S., Gillespie, M.A., Bevilacqua, L., Harper, M.E., Rudnicki, M.A. Cell metabolism. (2005) [Pubmed]
  28. PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Wende, A.R., Huss, J.M., Schaeffer, P.J., Giguère, V., Kelly, D.P. Mol. Cell. Biol. (2005) [Pubmed]
  29. PGC-1alpha is induced by parathyroid hormone and coactivates Nurr1-mediated promoter activity in osteoblasts. Nervina, J.M., Magyar, C.E., Pirih, F.Q., Tetradis, S. Bone (2006) [Pubmed]
  30. SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD. Amat, R., Planavila, A., Chen, S.L., Iglesias, R., Giralt, M., Villarroya, F. J. Biol. Chem. (2009) [Pubmed]
  31. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Jäger, S., Handschin, C., St-Pierre, J., Spiegelman, B.M. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  32. Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. Akimoto, T., Pohnert, S.C., Li, P., Zhang, M., Gumbs, C., Rosenberg, P.B., Williams, R.S., Yan, Z. J. Biol. Chem. (2005) [Pubmed]
  33. PGC-1beta down-regulation is associated with reduced ERRalpha activity and MCAD expression in skeletal muscle of senescence-accelerated mice. Rodríguez-Calvo, R., Jové, M., Coll, T., Camins, A., Sánchez, R.M., Alegret, M., Merlos, M., Pallàs, M., Laguna, J.C., Vázquez-Carrera, M. J. Gerontol. A Biol. Sci. Med. Sci. (2006) [Pubmed]
  34. Dietary fat interacts with QTLs controlling induction of Pgc-1 alpha and Ucp1 during conversion of white to brown fat. Coulter, A.A., Bearden, C.M., Liu, X., Koza, R.A., Kozak, L.P. Physiol. Genomics (2003) [Pubmed]
  35. An increase in murine skeletal muscle peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) mRNA in response to exercise is mediated by beta-adrenergic receptor activation. Miura, S., Kawanaka, K., Kai, Y., Tamura, M., Goto, M., Shiuchi, T., Minokoshi, Y., Ezaki, O. Endocrinology (2007) [Pubmed]
  36. PPARgamma coactivator-1alpha expression during thyroid hormone- and contractile activity-induced mitochondrial adaptations. Irrcher, I., Adhihetty, P.J., Sheehan, T., Joseph, A.M., Hood, D.A. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  37. Muscle type-specific response of PGC-1alpha and oxidative enzymes during voluntary wheel running in mouse skeletal muscle. Ikeda, S., Kawamoto, H., Kasaoka, K., Hitomi, Y., Kizaki, T., Sankai, Y., Ohno, H., Haga, S., Takemasa, T. Acta physiologica (Oxford, England) (2006) [Pubmed]
  38. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Mootha, V.K., Handschin, C., Arlow, D., Xie, X., St Pierre, J., Sihag, S., Yang, W., Altshuler, D., Puigserver, P., Patterson, N., Willy, P.J., Schulman, I.G., Heyman, R.A., Lander, E.S., Spiegelman, B.M. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
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