Gene Review:
Il6ra - interleukin 6 receptor, alpha
Mus musculus
Synonyms:
CD126, IL-6 receptor alpha chain, IL-6 receptor subunit alpha, IL-6R, IL-6R 1, ...
- Prostaglandin E2 mediates growth arrest in NFS-60 cells by down-regulating interleukin-6 receptor expression. de Silva, K.I., Daud, A.N., Deng, J., Jones, S.B., Gamelli, R.L., Shankar, R. Biochem. J. (2003)
- Inverse regulation of interleukin-6 (IL-6) and IL-6 receptor in histamine deficient histidine decarboxylase-knock-out mice. Horváth, B.V., Falus, A., Tóth, S., Szalai, C., Lázár-Molnár, E., Holub, M.C., Buzás, E., Nagy, A., Fulop, A.K. Immunol. Lett. (2002)
- Unmasking by soluble IL-6 receptor of IL-6 effect on metastatic melanoma: growth inhibition and differentiation of B16-F10.9 tumor cells. Oh, J.W., Katz, A., Harroch, S., Eisenbach, L., Revel, M., Chebath, J. Oncogene (1997)
- Interleukin-6 receptor blockage ameliorates murine lupus nephritis. Kiberd, B.A. J. Am. Soc. Nephrol. (1993)
- Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma/plasmacytoma. Suematsu, S., Hibi, M., Sugita, T., Saito, M., Murakami, M., Matsusaka, T., Matsuda, T., Hirano, T., Taga, T., Kishimoto, T. Curr. Top. Microbiol. Immunol. (1990)
- Activation-induced inhibition of interleukin 6-mediated T cell survival and signal transducer and activator of transcription 1 signaling. Teague, T.K., Schaefer, B.C., Hildeman, D., Bender, J., Mitchell, T., Kappler, J.W., Marrack, P. J. Exp. Med. (2000)
- Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma. Hirota, H., Kiyama, H., Kishimoto, T., Taga, T. J. Exp. Med. (1996)
- Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min/+) colon epithelial cell line. Fenton, J.I., Hursting, S.D., Perkins, S.N., Hord, N.G. Carcinogenesis (2006)
- Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow. Lin, S.C., Yamate, T., Taguchi, Y., Borba, V.Z., Girasole, G., O'Brien, C.A., Bellido, T., Abe, E., Manolagas, S.C. J. Clin. Invest. (1997)
- Retinoic acid inhibits interleukin-6-induced macrophage differentiation and apoptosis in a murine hematopoietic cell line, Y6. Oritani, K., Kaisho, T., Nakajima, K., Hirano, T. Blood (1992)
- The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis. Wang, X.P., Schunck, M., Kallen, K.J., Neumann, C., Trautwein, C., Rose-John, S., Proksch, E. J. Invest. Dermatol. (2004)
- Differentiation and growth arrest signals are generated through the cytoplasmic region of gp130 that is essential for Stat3 activation. Yamanaka, Y., Nakajima, K., Fukada, T., Hibi, M., Hirano, T. EMBO J. (1996)
- Interleukin-6, hepatocyte growth factor, and their receptors in biliary epithelial cells during a type I ductular reaction in mice: interactions between the periductal inflammatory and stromal cells and the biliary epithelium. Liu, Z., Sakamoto, T., Ezure, T., Yokomuro, S., Murase, N., Michalopoulos, G., Demetris, A.J. Hepatology (1998)
- Expression of IL-6 receptor and GP130 in mouse bone marrow cells during osteoclast differentiation. Gao, Y., Morita, I., Maruo, N., Kubota, T., Murota, S., Aso, T. Bone (1998)
- Localization of interleukin-6 receptor mRNA in the pregnant and non-pregnant mouse uterus. Hondo, E., Kokubu, K., Kato, K., Kiso, Y. J. Reprod. Dev. (2005)
- Transcriptional induction of cyclooxygenase-2 in osteoblasts is involved in interleukin-6-induced osteoclast formation. Tai, H., Miyaura, C., Pilbeam, C.C., Tamura, T., Ohsugi, Y., Koishihara, Y., Kubodera, N., Kawaguchi, H., Raisz, L.G., Suda, T. Endocrinology (1997)
- Comparative gene expression in hematopoietic progenitor cells derived from embryonic stem cells. Lu, S.J., Li, F., Vida, L., Honig, G.R. Exp. Hematol. (2002)
- Pathogenic role of interleukin-6 in the development of sepsis. Part II: Significance of anti-interleukin-6 and anti-soluble interleukin-6 receptor-alpha antibodies in a standardized murine contact burn model. Pallua, N., Low, J.F., von Heimburg, D. Crit. Care Med. (2003)
- Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: elevated expression on B cells and absence on CD4+ cells. Kobayashi, I., Matsuda, T., Saito, T., Yasukawa, K., Kikutani, H., Hirano, T., Taga, T., Kishimoto, T. Int. Immunol. (1992)
- Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3. Takizawa, T., Yanagisawa, M., Ochiai, W., Yasukawa, K., Ishiguro, T., Nakashima, K., Taga, T. Cytokine (2001)
- Cytokine receptor repertoire and cytokine responsiveness of Ho(dull)/Rh(dull) stem cells with differing potentials for G1/S phase progression. Reddy, G.P., McAuliffe, C.I., Pang, L., Quesenberry, P.J., Bertoncello, I. Exp. Hematol. (2002)
- Effects on osteoclast and osteoblast activities in cultured mouse calvarial bones by synovial fluids from patients with a loose joint prosthesis and from osteoarthritis patients. Andersson, M.K., Lundberg, P., Ohlin, A., Perry, M.J., Lie, A., Stark, A., Lerner, U.H. Arthritis Res. Ther. (2007)
- Cloning of a murine IL-11 receptor alpha-chain; requirement for gp130 for high affinity binding and signal transduction. Hilton, D.J., Hilton, A.A., Raicevic, A., Rakar, S., Harrison-Smith, M., Gough, N.M., Begley, C.G., Metcalf, D., Nicola, N.A., Willson, T.A. EMBO J. (1994)
- STAT3 activation in stromal/osteoblastic cells is required for induction of the receptor activator of NF-kappaB ligand and stimulation of osteoclastogenesis by gp130-utilizing cytokines or interleukin-1 but not 1,25-dihydroxyvitamin D3 or parathyroid hormone. O'Brien, C.A., Gubrij, I., Lin, S.C., Saylors, R.L., Manolagas, S.C. J. Biol. Chem. (1999)
- Interleukin-6 is an autocrine growth factor for murine lung fibroblast subsets. Fries, K.M., Felch, M.E., Phipps, R.P. Am. J. Respir. Cell Mol. Biol. (1994)
- Expression of interleukin-6 receptors by pediatric acute lymphoblastic leukemia cells with the t(4;11) translocation: a possible target for therapy with recombinant IL6-Pseudomonas exotoxin. Gu, L., Zhou, M., Jurickova, I., Yeager, A.M., Kreitman, R.J., Phillips, C.N., Findley, H.W. Leukemia (1997)
- Leucine-58 in the putative 5th helical region of human interleukin (IL)-6 is important for activation of the IL-6 signal transducer, gp130. de Hon, F.D., Klaasse Bos, H.K., Ebeling, S.B., Grötzinger, J., Kurapkat, G., Rose-John, S., Aarden, L.A., Brakenhoff, J.P. FEBS Lett. (1995)