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Gene Review

March1  -  membrane-associated ring finger (C3HC4) 1

Mus musculus

Synonyms: 2900024D24Rik, BB085186, E3 ubiquitin-protein ligase MARCH1, MARCH-I, Membrane-associated RING finger protein 1, ...
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Disease relevance of March1

  • Unlike Aeromonas-associated gastroenteritis, septicemia did not peak in frequency during the warmer months but rather was most common in January through March, when approximately 40% of cases occurred [1].
  • A survey for the assessment of the ciguatera problem has been determined in Puako, South Kohala, on the Island of Hawaii. This is in the area of persistent ciguateric outbreaks during the months of January through March, caused by a specific species of fish (Cheilinus rhodochrous, red rose wrasse, or po'ou) [2].

High impact information on March1

  • Highlights from a Fundación Juan March Interdisciplinary Meeting. CD8+ T cells (TCD8+) play a critical role in immunity to viruses [3].
  • The highest fever rates were reported in February and March (when febrile illnesses are common) and in the 1-3 years age group (63% of the total surveillance population) [4].
  • A possible mechanism for anxiolytic and antidepressant effects of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) March [5].
  • Northern blot analysis showed that only a single species for each subunit was expressed in testis and the expression of each subunit increased dramatically from January to March during the maturation stages of the one-year cycle [6].
  • Replete females placed in the field on 2 December through to 8 March deposited eggs from 2 February through to 24 April; the eggs commenced hatching between 2 July and 21 August [7].

Biological context of March1

  • A recent Fundación Juan March Meeting brought together scientists working on the various steps in antigen presentation and T cell biology that contribute to immunodominance, whose understanding is key to rationally developing vaccines meant to elicit effective antiviral TCD8+ responses [3].
  • The descriptive kinetics of the spermatogenic process has been studied in the four chromosomal species of Spalax ehrenbergi between November and March, the active period of reproduction [8].

Anatomical context of March1

  • Two pools of whole buffalo follicular fluid collected in winter (December, January) and spring (March, April) season were fractionated by Sephadex G-200 column chromatography [9].

Associations of March1 with chemical compounds

  • Protective effect of alpha- and beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice [10].
  • Following the death of two Atlantic dolphins in a lagoon in March of 1989, the Hawaiian fishes in the lagoon were examined as a potential source of toxin(s) [11].
  • Eight groups of 30 animals each received bupivacaine (20 mg/kg i.p.) at a specific month of the year, i.e. February (second week), March (first week), May (fourth week), July (first week), September (fourth week), November (second and third weeks) and December (first week), at the same time of the day (10.00 h) [12].


  1. Aeromonas species in septicemia: laboratory characteristics and clinical observations. Janda, J.M., Guthertz, L.S., Kokka, R.P., Shimada, T. Clin. Infect. Dis. (1994) [Pubmed]
  2. A survey of ciguatera: assessment of Puako, Hawaii, associated with ciguatera toxin epidemics in humans. Hokama, Y., Asahina, A.Y., Titus, E., Shirai, J.L., Hong, T.W., Chun, S., Miyahara, J.T., Takata, D., Muranaka, A., Pang, E. J. Clin. Lab. Anal. (1993) [Pubmed]
  3. Immunodominance in TCD8+ responses to viruses: cell biology, cellular immunology, and mathematical models. Yewdell, J.W., Del Val, M. Immunity (2004) [Pubmed]
  4. Tolerability of modified tick-borne encephalitis vaccine FSME-IMMUN "NEW" in children: results of post-marketing surveillance. Pavlova, B.G., Loew-Baselli, A., Fritsch, S., Poellabauer, E.M., Vartian, N., Rinke, I., Ehrlich, H.J. Vaccine (2003) [Pubmed]
  5. A possible mechanism for anxiolytic and antidepressant effects of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) March. Aragão, G.F., Carneiro, L.M., Junior, A.P., Vieira, L.C., Bandeira, P.N., Lemos, T.L., Viana, G.S. Pharmacol. Biochem. Behav. (2006) [Pubmed]
  6. Molecular cloning of cDNA encoding two subunits of calcineurin from scallop testis: demonstration of stage-specific expression during maturation of the testis. Uryu, M., Nakatomi, A., Watanabe, M., Hatsuse, R., Yazawa, M. J. Biochem. (2000) [Pubmed]
  7. Field and laboratory studies on the timing of oviposition and hatching of the western black-legged tick, Ixodes pacificus (Acari: Ixodidae). Peavey, C.A., Lane, R.S. Exp. Appl. Acarol. (1996) [Pubmed]
  8. Descriptive kinetics of spermatogenesis in four chromosomal species of the Spalax ehrenbergi superspecies in Israel. Redi, C.A., Garagna, S., Heth, G., Nevo, E. J. Exp. Zool. (1986) [Pubmed]
  9. Inhibitory activity in buffalo follicular fluid and its elution pattern during different season. Srivastava, S.K., Pant, H.C. Indian J. Exp. Biol. (1999) [Pubmed]
  10. Protective effect of alpha- and beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. trunk wood resin, against acetaminophen-induced liver injury in mice. Oliveira, F.A., Chaves, M.H., Almeida, F.R., Lima, R.C., Silva, R.M., Maia, J.L., Brito, G.A., Santos, F.A., Rao, V.S. Journal of ethnopharmacology. (2005) [Pubmed]
  11. Causitive toxin(s) in the death of two Atlantic dolphins. Hokama, Y., Asahina, A.Y., Hong, T.W., Katsura, K., Shang, E., Miyahara, J.T., Sweeney, J.C., Stone, R. J. Clin. Lab. Anal. (1990) [Pubmed]
  12. Seasonal variations in the kinetics of bupivacaine in the mouse. Attolini, L., Gantenbein, M., Lorec, A.M., Bruguerolle, B. European journal of drug metabolism and pharmacokinetics. (1996) [Pubmed]
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