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Chemical Compound Review

protio     molecular hydrogen

Synonyms: hydrogen-1, AC1NUTH4, CHEBI:29236, (1)H, (1)1H, ...
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Disease relevance of molecular hydrogen

  • In the search for natural compounds useful against pruritus, alpha,beta-amyrins, the pentacyclic triterpenes isolated from the resin of popular medicinal plant Protium heptaphyllum were examined on scratching behavior induced by dextran T40 and compound 48/80 in mice [1].
  • Molecular hydrogen as an energy source for Helicobacter pylori [2].

Psychiatry related information on molecular hydrogen

  • Possible mechanisms of the exchange have been verified on the basis of the analysis of the variation of protium concentration in both the methyl and the methylene groups of propane in dependence of the reaction time [3].

High impact information on molecular hydrogen

  • Molecular hydrogen is strongly depleted in deuterium relative to water on Mars because of the very long lifetime of H2 (1200 years) [4].
  • Enrichment for protium was seen in alpha-helical secondary structure. 'Strong' HBs previously identified by mutagenesis and thermodynamic measurements are significantly enriched for protium [5].
  • Molecular hydrogen, reduced coenzyme F420, or reduced ferredoxin are used as electron donors [6].
  • Molecular hydrogen levels averaging over 40 microM were measured in organs (i.e., livers and spleens) of live mice, and levels within the intestinal tract (the presumed origin of the gas) were four times greater than this [7].
  • We have studied the effect of protium/deuterium substitution on different kinetics associated with the turnovers of cytochrome b(6)f complex in whole cells of Chlamydomonas reinhardtii [8].

Biological context of molecular hydrogen

  • When the decarboxylations of (2S-methionine, (2S)-norleucine, and (2R)-S-ethyl-L-cysteine were conducted on a preparative scale in protium and deuterium oxide, unlabeled and deuteriated amines were formed [9].
  • We examine this idea with data on the habitat specificity of 35 western Amazonian species from the genera Protium, Crepidospermum, and Tetragastris in the monophyletic tribe Protieae (Burseraceae) mapped on a molecular-based phylogeny [10].

Anatomical context of molecular hydrogen


Associations of molecular hydrogen with other chemical compounds


Gene context of molecular hydrogen

  • Evidence that both protium and deuterium undergo significant tunneling in the reaction catalyzed by bovine serum amine oxidase [13].
  • When (2S)-methionine and the C-2 deuteriated isotopomer were incubated with the enzyme in deuterium oxide and protium oxide, respectively, and the products were converted to their camphanamide derivatives and analyzed by 1H NMR spectroscopy, it was evident that decarboxylation occurred with retention of configuration at C-2 [14].
  • Molecular hydrogen was also effective for the transformation of enol acetates to chiral acetates without additional acyl donors with the same catalyst system [15].

Analytical, diagnostic and therapeutic context of molecular hydrogen


  1. Pentacyclic triterpenoids, alpha,beta-amyrins, suppress the scratching behavior in a mouse model of pruritus. Oliveira, F.A., Lima-Junior, R.C., Cordeiro, W.M., Vieira-Júnior, G.M., Chaves, M.H., Almeida, F.R., Silva, R.M., Santos, F.A., Rao, V.S. Pharmacol. Biochem. Behav. (2004) [Pubmed]
  2. Molecular hydrogen as an energy source for Helicobacter pylori. Olson, J.W., Maier, R.J. Science (2002) [Pubmed]
  3. In situ (1)H and (13)C MAS NMR kinetic study of the mechanism of H/D exchange for propane on zeolite H-ZSM-5. Arzumanov, S.S., Reshetnikov, S.I., Stepanov, A.G., Parmon, V.N., Freude, D. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2005) [Pubmed]
  4. Detection of atomic deuterium in the upper atmosphere of Mars. Krasnopolsky, V.A., Mumma, M.J., Gladstone, G.R. Science (1998) [Pubmed]
  5. Hydrogen bonding and equilibrium isotope enrichment in histidine-containing proteins. Bowers, P.M., Klevit, R.E. Nat. Struct. Biol. (1996) [Pubmed]
  6. The unique biochemistry of methanogenesis. Deppenmeier, U. Prog. Nucleic Acid Res. Mol. Biol. (2002) [Pubmed]
  7. Respiratory hydrogen use by Salmonella enterica serovar Typhimurium is essential for virulence. Maier, R.J., Olczak, A., Maier, S., Soni, S., Gunn, J. Infect. Immun. (2004) [Pubmed]
  8. New insights on the proton pump associated with cytochrome b6f turnovers from the study of H/D substitution effects on the electrogenicity and electron transfer reactions. Deniau, C., Rappaport, F. Biochemistry (2000) [Pubmed]
  9. Streptomyces L-methionine decarboxylase: purification and properties of the enzyme and stereochemical course of substrate decarboxylation. Stevenson, D.E., Akhtar, M., Gani, D. Biochemistry (1990) [Pubmed]
  10. The contribution of edaphic heterogeneity to the evolution and diversity of Burseraceae trees in the western Amazon. Fine, P.V., Daly, D.C., Villa Muñoz, G., Mesones, I., Cameron, K.M. Evolution (2005) [Pubmed]
  11. Availability and use of molecular hydrogen as an energy substrate for Helicobacter species. Maier, R.J. Microbes Infect. (2003) [Pubmed]
  12. Reductive dehalogenation as a respiratory process. Holliger, C., Schumacher, W. Antonie Van Leeuwenhoek (1994) [Pubmed]
  13. Evidence that both protium and deuterium undergo significant tunneling in the reaction catalyzed by bovine serum amine oxidase. Grant, K.L., Klinman, J.P. Biochemistry (1989) [Pubmed]
  14. L-methionine decarboxylase from Dryopteris filix-mas: purification, characterization, substrate specificity, abortive transamination of the coenzyme, and stereochemical courses of substrate decarboxylation and coenzyme transamination. Stevenson, D.E., Akhtar, M., Gani, D. Biochemistry (1990) [Pubmed]
  15. Practical ruthenium/lipase-catalyzed asymmetric transformations of ketones and enol acetates to chiral acetates. Jung, H.M., Koh, J.H., Kim, M.J., Park, J. Org. Lett. (2000) [Pubmed]
  16. Norepinephrine metabolism in man using deuterium labelling: origin of 4-hydroxy-3-methoxymandelic acid. Mårdh, G., Anggård, E. J. Neurochem. (1984) [Pubmed]
  17. Preparation of omega trideuterated sulfidopeptide leukotrienes: analysis by FAB/MS. Prakash, C., Sweetman, B.J., Sivakumar, R., Taffer, I.M., Zipkin, R.E., Blair, I.A. Prostaglandins (1989) [Pubmed]
  18. Gastroprotective and anti-inflammatory effects of resin from Protium heptaphyllum in mice and rats. Oliveira, F.A., Vieira-Júnior, G.M., Chaves, M.H., Almeida, F.R., Florêncio, M.G., Lima, R.C., Silva, R.M., Santos, F.A., Rao, V.S. Pharmacol. Res. (2004) [Pubmed]
  19. Molecular hydrogen occupancy in binary THF-H2 clathrate hydrates by high resolution neutron diffraction. Hester, K.C., Strobel, T.A., Sloan, E.D., Koh, C.A., Huq, A., Schultz, A.J. The journal of physical chemistry. B, Condensed matter, materials, surfaces, interfaces & biophysical. (2006) [Pubmed]
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