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Gene Review

WNT9B  -  wingless-type MMTV integration site family...

Homo sapiens

Synonyms: Protein Wnt-14b, Protein Wnt-15, Protein Wnt-9b, UNQ6973/PRO21956, WNT14B, ...
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Disease relevance of WNT9B


High impact information on WNT9B

  • We report an analysis of mouse Wnt9b (also called Wnt15 and Wnt14b), including its cDNA sequence, chromosomal mapping, epithelial cell transforming activity, adult and embryonic tissue expression patterns, and evolution [4].
  • We have isolated a number of WNT sequences from human genomic DNA, two of which, designated WNT14 and WNT15, represent novel members of the Wnt gene family [5].
  • Intergenic region between WNT14B and WNT3 genes was about 33 kb in size [3].
  • WNT14B mRNA was significantly up-regulated by all-trans retinoic acid in NT2 cells [3].
  • These results indicate that WNT14 is a target gene of IFNgamma in MKN45 cells, and that WNT14B is a target gene of estrogen in MCF-7 cells [2].

Biological context of WNT9B


Anatomical context of WNT9B


Associations of WNT9B with chemical compounds


Analytical, diagnostic and therapeutic context of WNT9B


  1. WNT3-WNT14B and WNT3A-WNT14 gene clusters (Review). Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  2. Expression of WNT14 and WNT14B mRNAs in human cancer, up-regulation of WNT14 by IFNgamma and up-regulation of WNT14B by beta-estradiol. Kirikoshi, H., Sekihara, H., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  3. Molecular cloning and characterization of WNT14B, a novel member of the WNT gene family. Kirikoshi, H., Sekihara, H., Katoh, M. Int. J. Oncol. (2001) [Pubmed]
  4. Mouse Wnt9b transforming activity, tissue-specific expression, and evolution. Qian, J., Jiang, Z., Li, M., Heaphy, P., Liu, Y.H., Shackleford, G.M. Genomics (2003) [Pubmed]
  5. Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21. Bergstein, I., Eisenberg, L.M., Bhalerao, J., Jenkins, N.A., Copeland, N.G., Osborne, M.P., Bowcock, A.M., Brown, A.M. Genomics (1997) [Pubmed]
  6. Molecular cloning and characterization of mouse Wnt14b, clustered with mouse Wnt3 in mouse chromosome 11. Kirikoshi, H., Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  7. Comparative genomics on Wnt3-Wnt9b gene cluster. Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
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