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Gene Review

ZNF24  -  zinc finger protein 24

Homo sapiens

Synonyms: KOX17, RSG-A, Retinoic acid suppression protein A, ZNF191, ZSCAN3, ...
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Disease relevance of ZNF24

  • AIM: Human zinc finger protein 191 (ZNF191) was cloned and characterized as a Kruppel-like transcription factor, which might be relevant to many diseases such as liver cancer, neuropsychiatric and cardiovascular diseases [1].

High impact information on ZNF24

  • Two specific proteins, ZNF191, a zinc finger protein, and HBP1, an HMG box transcription factor, which bind the TCAT motif, were then cloned [2].
  • Biochemical binding studies confirmed the associations of ZNF191 and SDP1 with ZNF202 and established the SCAN domain as a selective hetero- and homotypic oligomerization domain [3].
  • The interacting ZNF191 protein represents the family of SCAN domain-containing zinc finger proteins, whereas the novel SDP1 protein establishes a new family of genes that encode an isolated SCAN domain [3].
  • The results indicated that ZNF255 might be a conditional transactivator, whereas ZNF253 and ZNF191 displayed a suppressive effect on the transcription in yeast and/or mammalian systems [4].
  • Allelic variations of HUMTH01 have been stated to have a quantitative silencing effect on TH gene expression and to correlate with quantitative and qualitative changes in the binding by ZNF191 [5].

Biological context of ZNF24


Anatomical context of ZNF24


Analytical, diagnostic and therapeutic context of ZNF24


  1. Establishment of transgenic mice carrying gene encoding human zinc finger protein 191. Li, J.Z., Chen, X., Yang, H., Wang, S.L., Gong, X.L., Feng, H., Guo, B.Y., Yu, L., Wang, Z.G., Fu, J.L. World J. Gastroenterol. (2004) [Pubmed]
  2. Quantitative effects on gene silencing by allelic variation at a tetranucleotide microsatellite. Albanèse, V., Biguet, N.F., Kiefer, H., Bayard, E., Mallet, J., Meloni, R. Hum. Mol. Genet. (2001) [Pubmed]
  3. The SCAN domain mediates selective oligomerization. Schumacher, C., Wang, H., Honer, C., Ding, W., Koehn, J., Lawrence, Q., Coulis, C.M., Wang, L.L., Ballinger, D., Bowen, B.R., Wagner, S. J. Biol. Chem. (2000) [Pubmed]
  4. Molecular cloning of six novel Krüppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB. Han, Z.G., Zhang, Q.H., Ye, M., Kan, L.X., Gu, B.W., He, K.L., Shi, S.L., Zhou, J., Fu, G., Mao, M., Chen, S.J., Yu, L., Chen, Z. J. Biol. Chem. (1999) [Pubmed]
  5. The zinc finger transcription factor 191 is required for early embryonic development and cell proliferation. Li, J., Chen, X., Yang, H., Wang, S., Guo, B., Yu, L., Wang, Z., Fu, J. Exp. Cell Res. (2006) [Pubmed]
  6. Chromosomal localization of two human zinc finger protein genes, ZNF24 (KOX17) and ZNF29 (KOX26), to 18q12 and 17p13-p12, respectively. Rousseau-Merck, M.F., Huebner, K., Berger, R., Thiesen, H.J. Genomics (1991) [Pubmed]
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