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Gene Review

SCAND1  -  SCAN domain containing 1

Homo sapiens

Synonyms: RAZ1, SCAN domain-containing protein 1, SDP1
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Disease relevance of SCAND1

  • RAZ1 maps to chromosome 20q11 at a region frequently disrupted in various leukemias [1].
  • Castanospermine (CSP), an inhibitor of alpha-glucosidase, enhanced immunoglobulin (Ig) release in a Staphylococcus aureus Cowan I (SAC)-induced lymphocyte culture (Scand. J. Immunol. 1990. 32: 529) [2].
  • Three Norwegians, a couple and their daughter, died from AIDS in 1976 after up to 10 years of clinical manifestations of HIV infection (Lindboe et al., 1986, Acta Pathol. Microbiol, Immunol. Scand. 94, 117-123; Frøland et al., 1988, Lancet i, 1344-1345) [3].
  • Perch (Acta Pathol. Microbiol. Scand. 25:703-714, 1948) and against newly defined types to produce separate schemes for O-grouping Proteus vulgaris and Proteus mirabilis [4].
  • Based on a limited number of biochemical properties, a system for biotyping Haemophilus influenzae (M. Kilian, Acta Pathol. Microbiol, Scand. Sect. B82:835-842, 1976) was used to analyze the relationship of biotype to source of infection and antibiotic resistance for 600 clinical strains [5].

High impact information on SCAND1


Chemical compound and disease context of SCAND1

  • Re: "Role of the herbicide atrazine in the development of non-Hodgkin's lymphoma" by S Hoar Zahm, DD Weisburger, KP Kantor, FF Holmes, A Blair. Scand J Work Environ Health 1993; 19:108-14 [9].
  • Re: "Triazine herbicides and ovarian epithelial neoplasms" by A Donna, P Crosignani, F Robutti, PG Betta, R Bocca, N Mariani, F Ferrario, R Fissi, F Berrino Scand J Work Environ Health 1989 [10].
  • Acta Paediatr Scand, 72:167, 1983.--Two groups of infants aged 2 to 20 months with moderate to severe dehydration were randomly assigned to either sucrose high sodium (90 mEq/l) or sucrose low sodium (58 mEq/l) solution in a double blind manner [11].

Biological context of SCAND1

  • SCAND1 is a truncated SCAN box protein, lacking the zinc finger region and the NY-REN-21/SCAND1 heterodimer is asymmetric concerning the DNA binding region [12].
  • RAZ1 transcription start sites were mapped by primer extension and confirmed by identification of the RAZ1 promoter in the 5' flanking genomic DNA [1].
  • The RAZ1 gene produces two transcripts with variant 5'-untranslated regions containing identical open reading frames that express a 28 kDa protein in vitro [1].
  • In confirmation of Funder and Wieth (Funder, J., Wieth, J.O. 1966. Scand. J. Lab. Invest. 18:167-180) cell water and cell volume was found to vary directly with the summed content of Na + K [13].
  • This was done by merging published in vitro data on DCM metabolism and partitioning with inhalation toxicokinetic data (Astrand et al., 1975, Scand. J. Work.Environ. Health 1, 78-94) from five human volunteers, using the MCMC technique within a population PBPK model [14].

Anatomical context of SCAND1

  • RAZ1 mRNA expression was detected in various human tissues and cell lines by Northern blot analysis and multiple tissue expression arrays [1].
  • The palmitoyl-CoA hydrolase activity, which in human blood platelets is mainly localized in the cytosol fraction [Berge, Vollset & Farstad (1980) Scand. J. Clin. Lab. Invest. 40, 271--279], was found to be extremely labile [15].
  • (Scand. J. Immunol. (1980) 11, 147) for non-human phagocytes [16].
  • The intervertebral disk is routinely subjected to compressive loads that alter with posture and muscle activity and can produce pressures > 2 MPa in human lumbar disks in vivo (A. Nachemson and G. Elfstrom. Scand. J. Rehabil. Med. 2, Suppl. 1:1-40, 1979; A. Nachemson and J. M. Morris. J. Bone Jt. Surg. Am. Vol. 46A: 1077-1092, 1964) [17].
  • Ethanol intake prevented the previously observed [Nilsson-Ehle, P., S. Carlström, and P. Belfrage, Scand, J. Clin. Lab. Invest. 35:373 (1975)] glucose-induced rapid elevation of adipose tissue LLA but had small effects on this enzymatic activity when given alone or together with lipid [18].

Associations of SCAND1 with chemical compounds

  • We recently reported (Acta Paediatr Scand 1992;8: 580-4) three preterm infants with severe respiratory distress syndrome and abnormal glucose profiles for the first 5 days of life who subsequently died in infancy; only at autopsy were they shown to have abnormal glucose-6-phosphatase activity [19].
  • (Scand J Clin Invest 1974;33:215-30), the caffeine buffer (CAF) of Vink et al [20].
  • Bile acid excretion was studied in 9 human subjects simultaneously by the Lindstedt (Lindstedt, S. 1957. Acta Physiol. Scand. 40:1-9) isotopic turnovermethod and by fecal chemical analysis during a balance study [21].
  • 4. Taking a value of the Swain-Scott nucleophilicity (n) of 2.5 for an average DNA nucleotide unit [Walles & Ehrenberg (1969) Acta Chem. Scand. 23, 1080-1084], a value of n of about 1 for the phosphodiester group was deduced, and this value was found to be 2-3 units less than that for the N-7 atom of guanine in DNA [22].
  • The (3)H/(14)C ratio of biliary chenodeoxycholic acid and the specific activity of biliary chenodeoxycholic acid were determined to permit calculation of pool size and turnover rate by the conventional isotope dilution procedure of Lindstedt (1957. Acta Physiol. Scand. 40: 1) [23].

Other interactions of SCAND1


Analytical, diagnostic and therapeutic context of SCAND1

  • Reduction of the maximum vaginal surface electromyography (EMG) activity has previously been demonstrated in women with stress, urge, and mixed incontinence in comparison with healthy volunteers [Gunnarsson and Mattiasson, Scand J Urol Nephol 157:89-95, 1994] [27].
  • The control group consisted of a normal Danish population (2424 females and 2431 males) [Rølling, 1980: Scand J Dent Res 88:365-369; Ravn and Nielsen, 1973: Tandlaaegebladet 77:12-22] [28].
  • The concept of study base [Miettinen, Scand J Work Environ Health 8 (1982):suppl 1, 7-14] as referring to the health experience of the study population over time, and a clear recognition of open and closed populations, ie, with or without turnover, make the structure of the case-referent study clearer [29].
  • According to an epidemiologic study (Scand J Med Sci 1996/ 6: 297-302) the mechanism of "handball goalie's elbow" may be forced hyperextension [30].
  • A method for assessing the potential extent of confounding in cohort studies described previously by Axelson [Scand J Work Environ Health 4 (1978) 98-102] can be adapted for use in nested case-referent studies [31].


  1. Characterization of the SCAN box encoding RAZ1 gene: analysis of cDNA transcripts, expression, and cellular localization. Sander, T.L., Morris, J.F. Gene (2002) [Pubmed]
  2. Glycosidase inhibitors (castanospermine and swainsonine) and neuraminidase inhibit pokeweed mitogen-induced B cell maturation. Karasuno, T., Kanayama, Y., Nishiura, T., Nakao, H., Yonezawa, T., Tarui, S. Eur. J. Immunol. (1992) [Pubmed]
  3. Sequence analysis of HIV-1 group O from Norwegian patients infected in the 1960s. Jonassen, T.O., Stene-Johansen, K., Berg, E.S., Hungnes, O., Lindboe, C.F., Frøland, S.S., Grinde, B. Virology (1997) [Pubmed]
  4. Separate O-grouping schemes for serotyping clinical isolates of Proteus vulgaris and Proteus mirabilis. Penner, J.L., Hennessy, J.N. J. Clin. Microbiol. (1980) [Pubmed]
  5. Biochemical characteristics of Haemophilus influenzae in relationship to source of isolation and antibiotic resistance. Albritton, W.L., Penner, S., Slaney, L., Brunton, J. J. Clin. Microbiol. (1978) [Pubmed]
  6. Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations. Sander, T.L., Haas, A.L., Peterson, M.J., Morris, J.F. J. Biol. Chem. (2000) [Pubmed]
  7. Separation of human neutrophil plasma membrane from intracellular vesicles containing alkaline phosphatase and NADPH oxidase activity by free flow electrophoresis. Sengeløv, H., Nielsen, M.H., Borregaard, N. J. Biol. Chem. (1992) [Pubmed]
  8. Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. Reprinted from Acta. Physiol. Scand. 23: 110-127, 1951. Ussing, H.H., Zerahn, K. J. Am. Soc. Nephrol. (1999) [Pubmed]
  9. Re: "Role of the herbicide atrazine in the development of non-Hodgkin's lymphoma" by S Hoar Zahm, DD Weisburger, KP Kantor, FF Holmes, A Blair. Scand J Work Environ Health 1993; 19:108-14. Crosignani, P., Berrino, F. Scandinavian journal of work, environment & health. (1994) [Pubmed]
  10. Re: "Triazine herbicides and ovarian epithelial neoplasms" by A Donna, P Crosignani, F Robutti, PG Betta, R Bocca, N Mariani, F Ferrario, R Fissi, F Berrino Scand J Work Environ Health 1989. Minder, C.E. Scandinavian journal of work, environment & health. (1990) [Pubmed]
  11. Oral hydration of diarrhoeal dehydration. Comparison of high and low sodium concentration in rehydration solutions. Saberi, M.S., Assaee, M. Acta paediatrica Scandinavica. (1983) [Pubmed]
  12. Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1. Carneiro, F.R., Silva, T.C., Alves, A.C., Haline-Vaz, T., Gozzo, F.C., Zanchin, N.I. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  13. Interrelations among Na and K content, cell volume, and buoyant density in human red blood cell populations. Lee, P., Kirk, R.G., Hoffman, J.F. J. Membr. Biol. (1984) [Pubmed]
  14. Physiologically based pharmacokinetic modeling of inhalation exposure of humans to dichloromethane during moderate to heavy exercise. Jonsson, F., Bois, F., Johanson, G. Toxicol. Sci. (2001) [Pubmed]
  15. Isolation of palmitoyl-CoA hydrolases from human blood platelets. Berge, R.K., Hagen, L.E., Farstad, M. Biochem. J. (1981) [Pubmed]
  16. A simple quantitative fluorimetric assay of in vitro phagocytosis in human neutrophils. Oben, J.A., Foreman, J.C. J. Immunol. Methods (1988) [Pubmed]
  17. Effects of hydrostatic pressure on matrix synthesis in different regions of the intervertebral disk. Ishihara, H., McNally, D.S., Urban, J.P., Hall, A.C. J. Appl. Physiol. (1996) [Pubmed]
  18. Effects of ethanol intake on lipoprotein lipase activity in adipose tissue of fasting subjects. Nilsson-Ehle, P. Lipids (1978) [Pubmed]
  19. Early detection of metabolic abnormalities in preterm infants impaired by disorders of blood glucose concentrations. Lyall, H., Burchell, A., Howie, P.W., Ogston, S., Hume, R. Clin. Chem. (1994) [Pubmed]
  20. Three direct spectrophotometric methods for determination of total bilirubin in neonatal and adult serum, adapted to the Technicon RA-1000 analyzer. Harrison, S.P., Barlow, I.M. Clin. Chem. (1989) [Pubmed]
  21. Estimation of bile acid excretion in man: comparison of isotopic turnover and fecal excretion methods. Subbiah, M.T., Tyler, N.E., Buscaglia, M.D., Marai, L. J. Lipid Res. (1976) [Pubmed]
  22. Alkylation of deoxyribonucleic acid by carcinogens dimethyl sulphate, ethyl methanesulphonate, N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea. Relative reactivity of the phosphodiester site thymidylyl(3'-5')thymidine. Swenson, D.H., Lawley, P.D. Biochem. J. (1978) [Pubmed]
  23. Suitability of [11, 12-3H2]chenodeoxycholic acid and [11, 12-3H2]lithocholic acid for isotope dilution studies of bile acid metabolism in man. Ng, P.Y., Allan, R.N., Hofmann, A.F. J. Lipid Res. (1977) [Pubmed]
  24. SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain. Babb, R., Bowen, B.R. Biochem. J. (2003) [Pubmed]
  25. Angiogenic growth factor response to acute systemic exercise in human skeletal muscle. Gavin, T.P., Robinson, C.B., Yeager, R.C., England, J.A., Nifong, L.W., Hickner, R.C. J. Appl. Physiol. (2004) [Pubmed]
  26. Clarification of the identity of the major M2 autoantigen in primary biliary cirrhosis. Fussey, S.P., West, S.M., Lindsay, J.G., Ragan, C.I., James, O.F., Bassendine, M.F., Yeaman, S.J. Clin. Sci. (1991) [Pubmed]
  27. Female stress, urge, and mixed urinary incontinence are associated with a chronic and progressive pelvic floor/vaginal neuromuscular disorder: An investigation of 317 healthy and incontinent women using vaginal surface electromyography. Gunnarsson, M., Mattiasson, A. Neurourology and urodynamics. (1999) [Pubmed]
  28. Tooth agenesis in Down syndrome. Russell, B.G., Kjaer, I. Am. J. Med. Genet. (1995) [Pubmed]
  29. The case-referent study--some comments on its structure, merits and limitations. Axelson, O. Scandinavian journal of work, environment & health. (1985) [Pubmed]
  30. Hyperextension of the elbow joint: pathoanatomy and kinematics of ligament injuries. Tyrdal, S., Olsen, B.S. Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.]. (1998) [Pubmed]
  31. Assessing the possible extent of confounding in occupational case-referent studies. Checkoway, H., Waldman, G.T. Scandinavian journal of work, environment & health. (1985) [Pubmed]
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