Disease relevance of SCAND1

• RAZ1 maps to chromosome 20q11 at a region frequently disrupted in various leukemias [1].
• Castanospermine (CSP), an inhibitor of alpha-glucosidase, enhanced immunoglobulin (Ig) release in a Staphylococcus aureus Cowan I (SAC)-induced lymphocyte culture (Scand. J. Immunol. 1990. 32: 529) [2].
• Three Norwegians, a couple and their daughter, died from AIDS in 1976 after up to 10 years of clinical manifestations of HIV infection (Lindboe et al., 1986, Acta Pathol. Microbiol, Immunol. Scand. 94, 117-123; Frøland et al., 1988, Lancet i, 1344-1345) [3].
• Perch (Acta Pathol. Microbiol. Scand. 25:703-714, 1948) and against newly defined types to produce separate schemes for O-grouping Proteus vulgaris and Proteus mirabilis [4].
• Based on a limited number of biochemical properties, a system for biotyping Haemophilus influenzae (M. Kilian, Acta Pathol. Microbiol, Scand. Sect. B82:835-842, 1976) was used to analyze the relationship of biotype to source of infection and antibiotic resistance for 600 clinical strains [5].

High impact information on SCAND1

• Co-immunoprecipitation assays demonstrate that the SCAN box domain of MZF1B is necessary for association with RAZ1 [6].
• RAZ1 is a novel cDNA that encodes a SCAN-related domain and arginine-rich region but no zinc finger motifs [6].
• A bone marrow cDNA library was screened for proteins interacting with the MZF1B SCAN box domain and RAZ1 (SCAN-related protein associated with MZF1B) was identified [6].
• Plasma membrane vesicles, identified by HLA class I antigen mixed enzyme-linked immunosorbent assay (Bjerrum, O. W., and Borregaard, N. (1990) Scand. J. Immunol. 31, 305-313) and 125I applied to cells before cavitation, were clearly separated from secretory vesicles [7].
• Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. Reprinted from Acta. Physiol. Scand. 23: 110-127, 1951 [8].

Chemical compound and disease context of SCAND1

• Re: "Role of the herbicide atrazine in the development of non-Hodgkin's lymphoma" by S Hoar Zahm, DD Weisburger, KP Kantor, FF Holmes, A Blair. Scand J Work Environ Health 1993; 19:108-14 [9].
• Re: "Triazine herbicides and ovarian epithelial neoplasms" by A Donna, P Crosignani, F Robutti, PG Betta, R Bocca, N Mariani, F Ferrario, R Fissi, F Berrino Scand J Work Environ Health 1989 [10].
• Acta Paediatr Scand, 72:167, 1983.--Two groups of infants aged 2 to 20 months with moderate to severe dehydration were randomly assigned to either sucrose high sodium (90 mEq/l) or sucrose low sodium (58 mEq/l) solution in a double blind manner [11].

Biological context of SCAND1

• SCAND1 is a truncated SCAN box protein, lacking the zinc finger region and the NY-REN-21/SCAND1 heterodimer is asymmetric concerning the DNA binding region [12].
• RAZ1 transcription start sites were mapped by primer extension and confirmed by identification of the RAZ1 promoter in the 5' flanking genomic DNA [1].
• The RAZ1 gene produces two transcripts with variant 5'-untranslated regions containing identical open reading frames that express a 28 kDa protein in vitro [1].
• In confirmation of Funder and Wieth (Funder, J., Wieth, J.O. 1966. Scand. J. Lab. Invest. 18:167-180) cell water and cell volume was found to vary directly with the summed content of Na + K [13].
• This was done by merging published in vitro data on DCM metabolism and partitioning with inhalation toxicokinetic data (Astrand et al., 1975, Scand. J. Work.Environ. Health 1, 78-94) from five human volunteers, using the MCMC technique within a population PBPK model [14].

Anatomical context of SCAND1

• RAZ1 mRNA expression was detected in various human tissues and cell lines by Northern blot analysis and multiple tissue expression arrays [1].
• The palmitoyl-CoA hydrolase activity, which in human blood platelets is mainly localized in the cytosol fraction [Berge, Vollset & Farstad (1980) Scand. J. Clin. Lab. Invest. 40, 271--279], was found to be extremely labile [15].
• (Scand. J. Immunol. (1980) 11, 147) for non-human phagocytes [16].
• The intervertebral disk is routinely subjected to compressive loads that alter with posture and muscle activity and can produce pressures > 2 MPa in human lumbar disks in vivo (A. Nachemson and G. Elfstrom. Scand. J. Rehabil. Med. 2, Suppl. 1:1-40, 1979; A. Nachemson and J. M. Morris. J. Bone Jt. Surg. Am. Vol. 46A: 1077-1092, 1964) [17].
• Ethanol intake prevented the previously observed [Nilsson-Ehle, P., S. Carlström, and P. Belfrage, Scand, J. Clin. Lab. Invest. 35:373 (1975)] glucose-induced rapid elevation of adipose tissue LLA but had small effects on this enzymatic activity when given alone or together with lipid [18].

Associations of SCAND1 with chemical compounds

• We recently reported (Acta Paediatr Scand 1992;8: 580-4) three preterm infants with severe respiratory distress syndrome and abnormal glucose profiles for the first 5 days of life who subsequently died in infancy; only at autopsy were they shown to have abnormal glucose-6-phosphatase activity [19].
• (Scand J Clin Invest 1974;33:215-30), the caffeine buffer (CAF) of Vink et al [20].
• Bile acid excretion was studied in 9 human subjects simultaneously by the Lindstedt (Lindstedt, S. 1957. Acta Physiol. Scand. 40:1-9) isotopic turnovermethod and by fecal chemical analysis during a balance study [21].
• 4. Taking a value of the Swain-Scott nucleophilicity (n) of 2.5 for an average DNA nucleotide unit [Walles & Ehrenberg (1969) Acta Chem. Scand. 23, 1080-1084], a value of n of about 1 for the phosphodiester group was deduced, and this value was found to be 2-3 units less than that for the N-7 atom of guanine in DNA [22].
• The (3)H/(14)C ratio of biliary chenodeoxycholic acid and the specific activity of biliary chenodeoxycholic acid were determined to permit calculation of pool size and turnover rate by the conventional isotope dilution procedure of Lindstedt (1957. Acta Physiol. Scand. 40: 1) [23].

Other interactions of SCAND1

• In a yeast two-hybrid experiment using the zinc-finger transcription factor ZNF202 as bait, we previously identified the SCAN-domain-containing protein SDP1 [24].
• NY-REN-21 interaction with SCAND1 was identified using the yeast two-hybrid system and confirmed using recombinant proteins [12].
• This result indicates that NY-REN-21 can function either as a homodimer or as a heterodimer with SCAND1 [12].
• Acta Physiol Scand 175: 201-209, 2002); and 3) VEGF protein is decreased immediately after exercise [25].
• 2. The evidence that a 75 kDa subunit of complex I of the respiratory chain is a major autoantigen (Frostell, Mendel-Hartvig, Nelson, Totterman, Bjorkland & Ragan, Scand. J. Immunol. 1988; 28, 157-65) is refuted [26].

Analytical, diagnostic and therapeutic context of SCAND1

• Reduction of the maximum vaginal surface electromyography (EMG) activity has previously been demonstrated in women with stress, urge, and mixed incontinence in comparison with healthy volunteers [Gunnarsson and Mattiasson, Scand J Urol Nephol 157:89-95, 1994] [27].
• The control group consisted of a normal Danish population (2424 females and 2431 males) [Rølling, 1980: Scand J Dent Res 88:365-369; Ravn and Nielsen, 1973: Tandlaaegebladet 77:12-22] [28].
• The concept of study base [Miettinen, Scand J Work Environ Health 8 (1982):suppl 1, 7-14] as referring to the health experience of the study population over time, and a clear recognition of open and closed populations, ie, with or without turnover, make the structure of the case-referent study clearer [29].
• According to an epidemiologic study (Scand J Med Sci 1996/ 6: 297-302) the mechanism of "handball goalie's elbow" may be forced hyperextension [30].
• A method for assessing the potential extent of confounding in cohort studies described previously by Axelson [Scand J Work Environ Health 4 (1978) 98-102] can be adapted for use in nested case-referent studies [31].

References