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Gene Review

ZNF74  -  zinc finger protein 74

Homo sapiens

Synonyms: COS52, Cos52, ZFP520, ZNF520, Zfp520, ...
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Disease relevance of ZNF74


High impact information on ZNF74

  • Hamster-human somatic hybrid cell lines from a patient with der(22) syndrome and a patient with VCFS showed that the breakpoints occurred in an interval containing low-copy repeats, distal to RANBP1 and proximal to ZNF74 [2].
  • Furthermore, we demonstrate that KAP-1 but not TIF1alpha interacts with the KRAB multifinger ZNF74 in the nuclear matrix [3].
  • Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells [3].
  • We now report on the multifunctionality of the zinc finger domain of ZNF74 [4].
  • By far-Western analysis and coimmunoprecipitation studies, we demonstrate that ZNF74 interacts, via its zinc finger domain, with the hyperphosphorylated largest subunit of RNA polymerase II (pol IIo) but not with the hypophosphorylated form [4].

Biological context of ZNF74

  • The restricted binding to these homopolymers and not to poly(A) and poly(C) suggested that ZNF74 displays RNA sequence preferences [5].
  • The importance of the phosphorylation in this interaction is supported by the observation that phosphatase treatment inhibits ZNF74 binding [4].
  • The RNA binding properties of this protein and its tight association with the nuclear matrix, a subnuclear compartment involved in DNA replication as well as RNA synthesis and processing, suggest a role for ZNF74 in RNA metabolism [5].
  • Association of ZNF74 gene genotypes with age-at-onset of schizophrenia [6].
  • Thus, the restricted expression of ZNF74 in structures affected in DGS suggests a role for this putative regulator of gene expression in aspects of the DGS phenotype [7].

Anatomical context of ZNF74


Other interactions of ZNF74

  • The interaction of ZNF74 with KAP-1 did not prevent KAP-1 homomerization indicating that the oligomers most likely represent the transcriptionally active species [3].

Analytical, diagnostic and therapeutic context of ZNF74


  1. Isolation of a zinc finger gene consistently deleted in DiGeorge syndrome. Aubry, M., Demczuk, S., Desmaze, C., Aikem, M., Aurias, A., Julien, J.P., Rouleau, G.A. Hum. Mol. Genet. (1993) [Pubmed]
  2. Der(22) syndrome and velo-cardio-facial syndrome/DiGeorge syndrome share a 1.5-Mb region of overlap on chromosome 22q11. Funke, B., Edelmann, L., McCain, N., Pandita, R.K., Ferreira, J., Merscher, S., Zohouri, M., Cannizzaro, L., Shanske, A., Morrow, B.E. Am. J. Hum. Genet. (1999) [Pubmed]
  3. Oligomerization of transcriptional intermediary factor 1 regulators and interaction with ZNF74 nuclear matrix protein revealed by bioluminescence resonance energy transfer in living cells. Germain-Desprez, D., Bazinet, M., Bouvier, M., Aubry, M. J. Biol. Chem. (2003) [Pubmed]
  4. Direct interaction of the KRAB/Cys2-His2 zinc finger protein ZNF74 with a hyperphosphorylated form of the RNA polymerase II largest subunit. Grondin, B., Côté, F., Bazinet, M., Vincent, M., Aubry, M. J. Biol. Chem. (1997) [Pubmed]
  5. The KRAB zinc finger gene ZNF74 encodes an RNA-binding protein tightly associated with the nuclear matrix. Grondin, B., Bazinet, M., Aubry, M. J. Biol. Chem. (1996) [Pubmed]
  6. Association of ZNF74 gene genotypes with age-at-onset of schizophrenia. Takase, K., Ohtsuki, T., Migita, O., Toru, M., Inada, T., Yamakawa-Kobayashi, K., Arinami, T. Schizophr. Res. (2001) [Pubmed]
  7. ZNF74, a gene deleted in DiGeorge syndrome, is expressed in human neural crest-derived tissues and foregut endoderm epithelia. Ravassard, P., Côté, F., Grondin, B., Bazinet, M., Mallet, J., Aubry, M. Genomics (1999) [Pubmed]
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