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Gene Review

RANBP1  -  RAN binding protein 1

Homo sapiens

Synonyms: HTF9A, Ran-binding protein 1, Ran-specific GTPase-activating protein, RanBP1
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Disease relevance of RANBP1


High impact information on RANBP1


Biological context of RANBP1

  • RanBP1 is the first member of a new class of proteins regulating the binding and hydrolysis of GTP by Ras-related proteins [6].
  • Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1 [6].
  • Since the structure of the Ran-RanBP1-RanGAP complex showed RanBP1 to be located away from the active site, we reinvestigated the reaction using fluorescence spectroscopy under pre-steady-state conditions [7].
  • These results are consistent with the hypothesis that Ran functions directly in at least two pathways, one, dependent on RanBP1, that affects cell cycle progression and RNA export, and another, independent of RanBP1, that affects nuclear protein import [8].
  • Mammalian RanBP1 regulates centrosome cohesion during mitosis [9].

Anatomical context of RANBP1


Associations of RANBP1 with chemical compounds

  • We found that a novel Ran mutant with four of its five acidic C-terminal amino acids modified to alanine (RanC4A) has an approximately 20-fold reduced affinity for RanBP1 [11].
  • A leucine-rich nuclear export signal (NES) near the C terminus of RanBP1 is essential to maintain this distribution [12].
  • We now show that RanBP1 accumulates in nuclei of cells treated with the export inhibitor, leptomycin B, and collapse of the nucleocytoplasmic Ran:GTP gradient leads to equilibration of RanBP1 across the nuclear envelope [12].
  • A conserved cysteine residue in p97, Cys-158, is required for binding Ran-GDP/RanBP1, but not for binding of Ran-GTP to p97 [13].
  • The loss of affinity of RanBP1 for the triphosphate form of RanDeltaC was a result of both a decrease of the association rate and a moderately increased dissociation of the RanDeltaC.RanBP1 complex [14].

Physical interactions of RANBP1


Regulatory relationships of RANBP1


Other interactions of RANBP1


Analytical, diagnostic and therapeutic context of RANBP1


  1. Mutations in the nuclear export signal of human ran-binding protein RanBP1 block the Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1. Zolotukhin, A.S., Felber, B.K. J. Biol. Chem. (1997) [Pubmed]
  2. RanBP1, a velocardiofacial/DiGeorge syndrome candidate gene, is expressed at sites of mesenchymal/epithelial induction. Maynard, T.M., Haskell, G.T., Bhasin, N., Lee, J.M., Gassman, A.A., Lieberman, J.A., LaMantia, A.S. Mech. Dev. (2002) [Pubmed]
  3. Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import. Lindsay, M.E., Plafker, K., Smith, A.E., Clurman, B.E., Macara, I.G. Cell (2002) [Pubmed]
  4. Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. Vetter, I.R., Nowak, C., Nishimoto, T., Kuhlmann, J., Wittinghofer, A. Nature (1999) [Pubmed]
  5. A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export. Kehlenbach, R.H., Dickmanns, A., Kehlenbach, A., Guan, T., Gerace, L. J. Cell Biol. (1999) [Pubmed]
  6. Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1. Bischoff, F.R., Krebber, H., Smirnova, E., Dong, W., Ponstingl, H. EMBO J. (1995) [Pubmed]
  7. Biochemical characterization of the Ran-RanBP1-RanGAP system: are RanBP proteins and the acidic tail of RanGAP required for the Ran-RanGAP GTPase reaction? Seewald, M.J., Kraemer, A., Farkasovsky, M., Körner, C., Wittinghofer, A., Vetter, I.R. Mol. Cell. Biol. (2003) [Pubmed]
  8. Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing. Ren, M., Villamarin, A., Shih, A., Coutavas, E., Moore, M.S., LoCurcio, M., Clarke, V., Oppenheim, J.D., D'Eustachio, P., Rush, M.G. Mol. Cell. Biol. (1995) [Pubmed]
  9. Mammalian RanBP1 regulates centrosome cohesion during mitosis. Di Fiore, B., Ciciarello, M., Mangiacasale, R., Palena, A., Tassin, A.M., Cundari, E., Lavia, P. J. Cell. Sci. (2003) [Pubmed]
  10. RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import. Chi, N.C., Adam, E.J., Visser, G.D., Adam, S.A. J. Cell Biol. (1996) [Pubmed]
  11. Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1. Kehlenbach, R.H., Assheuer, R., Kehlenbach, A., Becker, J., Gerace, L. J. Biol. Chem. (2001) [Pubmed]
  12. Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1. Plafker, K., Macara, I.G. Mol. Cell. Biol. (2000) [Pubmed]
  13. Different binding domains for Ran-GTP and Ran-GDP/RanBP1 on nuclear import factor p97. Chi, N.C., Adam, E.J., Adam, S.A. J. Biol. Chem. (1997) [Pubmed]
  14. Dynamic and equilibrium studies on the interaction of Ran with its effector, RanBP1. Kuhlmann, J., Macara, I., Wittinghofer, A. Biochemistry (1997) [Pubmed]
  15. RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4. Hayashi, N., Yokoyama, N., Seki, T., Azuma, Y., Ohba, T., Nishimoto, T. Mol. Gen. Genet. (1995) [Pubmed]
  16. The C terminus of fragile X mental retardation protein interacts with the multi-domain Ran-binding protein in the microtubule-organising centre. Menon, R.P., Gibson, T.J., Pastore, A. J. Mol. Biol. (2004) [Pubmed]
  17. Ran-binding protein 5 (RanBP5) is related to the nuclear transport factor importin-beta but interacts differently with RanBP1. Deane, R., Schäfer, W., Zimmermann, H.P., Mueller, L., Görlich, D., Prehn, S., Ponstingl, H., Bischoff, F.R. Mol. Cell. Biol. (1997) [Pubmed]
  18. XMog1, a nuclear ran-binding protein in Xenopus, is a functional homologue of Schizosaccharomyces pombe mog1p that co-operates with RanBP1 to control generation of Ran-GTP. Nicolás, F.J., Moore, W.J., Zhang, C., Clarke, P.R. J. Cell. Sci. (2001) [Pubmed]
  19. GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358. Yaseen, N.R., Blobel, G. J. Biol. Chem. (1999) [Pubmed]
  20. A new role of ran GTPase. Nishimoto, T. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  21. Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily. Kutay, U., Hartmann, E., Treichel, N., Calado, A., Carmo-Fonseca, M., Prehn, S., Kraft, R., Gorlich, D., Bischoff, F.R. J. Biol. Chem. (2000) [Pubmed]
  22. Disruption of the RanBP17/Hox11L2 region by recombination with the TCRdelta locus in acute lymphoblastic leukemias with t(5;14)(q34;q11). Hansen-Hagge, T.E., Schäfer, M., Kiyoi, H., Morris, S.W., Whitlock, J.A., Koch, P., Bohlmann, I., Mahotka, C., Bartram, C.R., Janssen, J.W. Leukemia (2002) [Pubmed]
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