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Gene Review

BRCC3  -  BRCA1/BRCA2-containing complex, subunit 3

Homo sapiens

Synonyms: BRCA1-A complex subunit BRCC36, BRCA1/BRCA2-containing complex subunit 3, BRCA1/BRCA2-containing complex subunit 36, BRCC36, BRISC complex subunit BRCC36, ...
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Disease relevance of BRCC3


High impact information on BRCC3


Biological context of BRCC3


Anatomical context of BRCC3

  • Transient or stable expression of the epitope-tagged BRCC3 cDNA was associated with increased p-ERK in three different cell lines [4].

Other interactions of BRCC3


  1. Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Dong, Y., Hakimi, M.A., Chen, X., Kumaraswamy, E., Cooch, N.S., Godwin, A.K., Shiekhattar, R. Mol. Cell (2003) [Pubmed]
  2. Two chimaeric transcription units result from an inversion breaking intron 1 of the factor VIII gene and a region reportedly affected by reciprocal translocations in T-cell leukaemia. Brinke, A., Tagliavacca, L., Naylor, J., Green, P., Giangrande, P., Giannelli, F. Hum. Mol. Genet. (1996) [Pubmed]
  3. BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation. Chen, X., Arciero, C.A., Wang, C., Broccoli, D., Godwin, A.K. Cancer Res. (2006) [Pubmed]
  4. Expression of BRCC3, a novel cell cycle regulated molecule, is associated with increased phospho-ERK and cell proliferation. Boudreau, H.E., Broustas, C.G., Gokhale, P.C., Kumar, D., Mewani, R.R., Rone, J.D., Haddad, B.R., Kasid, U. Int. J. Mol. Med. (2007) [Pubmed]
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