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Gene Review

Rab27b  -  RAB27B, member RAS oncogene family

Mus musculus

Synonyms: 2310021G14Rik, B130064M09Rik, Ras-related protein Rab-27B
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High impact information on Rab27b


Associations of Rab27b with chemical compounds

  • In vitro assays demonstrated impaired aggregation with collagen and U46619 and reduced secretion of dense granules in both Rab27b and double KO strains [3].

Biological context of Rab27b

  • Normal expression of Rab27b is especially increased with terminal megakaryocyte differentiation and dependent on nuclear factor-erythroid 2 (NF-E2), a transcription factor required for thrombopoiesis [4].
  • These findings indicate that Rab27b is involved in pituitary hormone secretion, which further supports the idea that members of the Rab27 subfamily regulate the exocytosis of dense core granules containing peptide hormones in endocrine cells [5].
  • The mouse Rab27b cDNA shows 95% identity with the human cDNA at the protein level and maps to mouse chromosome 18 [6].

Anatomical context of Rab27b


Other interactions of Rab27b


  1. Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. Barral, D.C., Ramalho, J.S., Anders, R., Hume, A.N., Knapton, H.J., Tolmachova, T., Collinson, L.M., Goulding, D., Authi, K.S., Seabra, M.C. J. Clin. Invest. (2002) [Pubmed]
  2. Rab27b is associated with fusiform vesicles and may be involved in targeting uroplakins to urothelial apical membranes. Chen, Y., Guo, X., Deng, F.M., Liang, F.X., Sun, W., Ren, M., Izumi, T., Sabatini, D.D., Sun, T.T., Kreibich, G. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  3. Rab27b regulates number and secretion of platelet dense granules. Tolmachova, T., Abrink, M., Futter, C.E., Authi, K.S., Seabra, M.C. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  4. A role for Rab27b in NF-E2-dependent pathways of platelet formation. Tiwari, S., Italiano, J.E., Barral, D.C., Mules, E.H., Novak, E.K., Swank, R.T., Seabra, M.C., Shivdasani, R.A. Blood (2003) [Pubmed]
  5. Involvement of Rab27b in the regulated secretion of pituitary hormones. Zhao, S., Torii, S., Yokota-Hashimoto, H., Takeuchi, T., Izumi, T. Endocrinology (2002) [Pubmed]
  6. Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. Ramalho, J.S., Tolmachova, T., Hume, A.N., McGuigan, A., Gregory-Evans, C.Y., Huxley, C., Seabra, M.C. BMC Genet. (2001) [Pubmed]
  7. Rab27b association with melanosomes: dominant negative mutants disrupt melanosomal movement. Chen, Y., Samaraweera, P., Sun, T.T., Kreibich, G., Orlow, S.J. J. Invest. Dermatol. (2002) [Pubmed]
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