High impact information on RPP5

• Pronounced intraspecific haplotype divergence at the RPP5 complex disease resistance locus of Arabidopsis [1].
• RPP5 is part of a clustered multigene family encoding nucleotide binding-leucine-rich repeat (LRR) proteins [1].
• We compared 95 kb of DNA sequence carrying the Ler RPP5 haplotype with the corresponding 90 kb of Arabidopsis ecotype Columbia (Col-0) [1].
• The RPP5 haplotypes thus carry dynamic gene clusters with the potential to adapt rapidly to novel pathogen variants by gene duplication and modification of recognition capacity [1].
• However, a truncated form structurally similar to those of N and L6 is encoded by one or more other members of the RPP5 gene family that are tightly clustered on chromosome 4 [2].

Biological context of RPP5

• The organization of repeated units within the leucine-rich repeats encoded by the wild-type RPP5 gene and an RPP5 mutant allele provides molecular evidence for the heightened capacity of this domain to evolve novel configurations and potentially new disease resistance specificities [2].
• In contrast to N and L6, which produce predicted truncated products by alternative splicing, RPP5 appears to express only a single transcript corresponding to the full-length protein [2].
• A similar SA dependence was observed for the P. parasitica TIR and CC-class R genes RPP5 and RPP8, respectively [3].

Regulatory relationships of RPP5

• These data suggest that a RPP5-related resistance pathway is activated constitutively in snc1 [4].

Other interactions of RPP5

• Smaller blocks of synteny were identified between soyA2 and Arabidopsis chromosomes IV and V (near the RPP5 and RPP8 genes) and between soyA2 and Arabidopsis chromosomes I and V (near the PhyA and PhyC genes) [5].

References