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Gene Review

RPP5  -  TIR-NBS-LRR class disease resistance protein

Arabidopsis thaliana

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High impact information on RPP5


Biological context of RPP5

  • The organization of repeated units within the leucine-rich repeats encoded by the wild-type RPP5 gene and an RPP5 mutant allele provides molecular evidence for the heightened capacity of this domain to evolve novel configurations and potentially new disease resistance specificities [2].
  • In contrast to N and L6, which produce predicted truncated products by alternative splicing, RPP5 appears to express only a single transcript corresponding to the full-length protein [2].
  • A similar SA dependence was observed for the P. parasitica TIR and CC-class R genes RPP5 and RPP8, respectively [3].

Regulatory relationships of RPP5

  • These data suggest that a RPP5-related resistance pathway is activated constitutively in snc1 [4].

Other interactions of RPP5


  1. Pronounced intraspecific haplotype divergence at the RPP5 complex disease resistance locus of Arabidopsis. Noël, L., Moores, T.L., van Der Biezen, E.A., Parniske, M., Daniels, M.J., Parker, J.E., Jones, J.D. Plant Cell (1999) [Pubmed]
  2. The Arabidopsis downy mildew resistance gene RPP5 shares similarity to the toll and interleukin-1 receptors with N and L6. Parker, J.E., Coleman, M.J., Szabò, V., Frost, L.N., Schmidt, R., van der Biezen, E.A., Moores, T., Dean, C., Daniels, M.J., Jones, J.D. Plant Cell (1997) [Pubmed]
  3. Role of salicylic acid and NIM1/NPR1 in race-specific resistance in arabidopsis. Rairdan, G.J., Delaney, T.P. Genetics (2002) [Pubmed]
  4. Activation of an EDS1-mediated R-gene pathway in the snc1 mutant leads to constitutive, NPR1-independent pathogen resistance. Li, X., Clarke, J.D., Zhang, Y., Dong, X. Mol. Plant Microbe Interact. (2001) [Pubmed]
  5. Genome organization in dicots: genome duplication in Arabidopsis and synteny between soybean and Arabidopsis. Grant, D., Cregan, P., Shoemaker, R.C. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
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