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Gene Review

RPP8  -  disease resistance protein RPP8

Arabidopsis thaliana

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Disease relevance of RPP8


High impact information on RPP8


Biological context of RPP8

  • A similar SA dependence was observed for the P. parasitica TIR and CC-class R genes RPP5 and RPP8, respectively [5].
  • To understand these changes, we generated a whole genome transcript profile for RCY1-mediated resistance to cucumber mosaic virus strain Y (CMV-Y) in Arabidopsis [6].
  • We propose that antagonistic interactions between the SA and JA signaling mechanisms modulate defense gene expression and the activation of RCY1-conferred gene-for-gene resistance to CMV(Y) [7].
  • The RCY1 locus was mapped between two CAPS markers, DFR and T43968, which were located in the region containing genetically defined disease resistance genes and their homologues [8].

Anatomical context of RPP8

  • We also demonstrate that a variety of resistance-associated phenomena, including the TCV-induced accumulation of salicylic acid, camalexin and autofluorescent cell-wall material, correlate with the HR, suggesting the possibility that HRT is required for their activation [9].

Associations of RPP8 with chemical compounds

  • However, the absence of light did not affect either TCV-induced elevated levels of free SA or the expression of HRT [10].

Other interactions of RPP8

  • High levels of SA upregulate HRT expression via a PAD4-dependent pathway [11].
  • Here, we demonstrate that unlike most CC-NBS-LRR R genes, HRT/rrt-mediated resistance is dependent on EDS1 and independent of NDR1 [11].


  1. RCY1, an Arabidopsis thaliana RPP8/HRT family resistance gene, conferring resistance to cucumber mosaic virus requires salicylic acid, ethylene and a novel signal transduction mechanism. Takahashi, H., Miller, J., Nozaki, Y., Takeda, M., Shah, J., Hase, S., Ikegami, M., Ehara, Y., Dinesh-Kumar, S.P. Plant J. (2002) [Pubmed]
  2. Members of the Arabidopsis HRT/RPP8 family of resistance genes confer resistance to both viral and oomycete pathogens. Cooley, M.B., Pathirana, S., Wu, H.J., Kachroo, P., Klessig, D.F. Plant Cell (2000) [Pubmed]
  3. Intragenic recombination and diversifying selection contribute to the evolution of downy mildew resistance at the RPP8 locus of Arabidopsis. McDowell, J.M., Dhandaydham, M., Long, T.A., Aarts, M.G., Goff, S., Holub, E.B., Dangl, J.L. Plant Cell (1998) [Pubmed]
  4. Genome organization in dicots: genome duplication in Arabidopsis and synteny between soybean and Arabidopsis. Grant, D., Cregan, P., Shoemaker, R.C. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. Role of salicylic acid and NIM1/NPR1 in race-specific resistance in arabidopsis. Rairdan, G.J., Delaney, T.P. Genetics (2002) [Pubmed]
  6. Study of Arabidopsis thaliana resistome in response to cucumber mosaic virus infection using whole genome microarray. Marathe, R., Guan, Z., Anandalakshmi, R., Zhao, H., Dinesh-Kumar, S.P. Plant Mol. Biol. (2004) [Pubmed]
  7. Antagonistic interactions between the SA and JA signaling pathways in Arabidopsis modulate expression of defense genes and gene-for-gene resistance to cucumber mosaic virus. Takahashi, H., Kanayama, Y., Zheng, M.S., Kusano, T., Hase, S., Ikegami, M., Shah, J. Plant Cell Physiol. (2004) [Pubmed]
  8. Mapping the virus and host genes involved in the resistance response in cucumber mosaic virus-Infected Arabidopsis thaliana. Takahashi, H., Suzuki, M., Natsuaki, K., Shigyo, T., Hino, K., Teraoka, T., Hosokawa, D., Ehara, Y. Plant Cell Physiol. (2001) [Pubmed]
  9. Identification of an Arabidopsis locus required for resistance to turnip crinkle virus. Dempsey, D.A., Pathirana, M.S., Wobbe, K.K., Klessig, D.F. Plant J. (1997) [Pubmed]
  10. Light-dependent hypersensitive response and resistance signaling against Turnip Crinkle Virus in Arabidopsis. Chandra-Shekara, A.C., Gupte, M., Navarre, D., Raina, S., Raina, R., Klessig, D., Kachroo, P. Plant J. (2006) [Pubmed]
  11. Signaling requirements and role of salicylic acid in HRT- and rrt-mediated resistance to turnip crinkle virus in Arabidopsis. Chandra-Shekara, A.C., Navarre, D., Kachroo, A., Kang, H.G., Klessig, D., Kachroo, P. Plant J. (2004) [Pubmed]
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