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Gene Review


Arabidopsis thaliana

Synonyms: BAL, BALL, CONSTITUTIVE 1, DL4475C, FCAALL.51, ...
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Disease relevance of SNC1

  • In the npr1-1 background, the snc1 mutation resulted in constitutive resistance to Pseudomonas syringae maculicola ES4326 and Peronospora parasitica Noco2 [1].

High impact information on SNC1

  • The Arabidopsis thaliana suppressor of npr1-1, constitutive 1 (snc1) mutant contains a gain-of-function mutation in a Toll Interleukin1 receptor-nucleotide binding-Leu-rich repeat-type resistance gene (R-gene), which leads to constitutive activation of disease resistance response against pathogens [2].
  • In a screen for suppressors of snc1, a recessive mutation, designated mos3 (for modifier of snc1,3), was found to suppress the constitutive pathogenesis-related gene expression and resistance to virulent Pseudomonas syringae maculicola ES4326 and Peronospora parasitica Noco2 in snc1 [2].
  • BON1 is a negative regulator of a haplotype-specific Resistance (R) gene SNC1 [3].
  • In addition, a feedback amplification of the SNC1 gene involving salicylic acid is subject to temperature control, accounting for the regulation of growth and defense by temperature in bon1-1 and many other mutants [3].
  • The bon1-1 loss-of-function mutation activates SNC1, leading to constitutive defense responses and, consequently, reduced cell growth [3].

Biological context of SNC1


Associations of SNC1 with chemical compounds


Regulatory relationships of SNC1

  • These data suggest that a RPP5-related resistance pathway is activated constitutively in snc1 [1].

Other interactions of SNC1

  • Activation of an EDS1-mediated R-gene pathway in the snc1 mutant leads to constitutive, NPR1-independent pathogen resistance [1].


  1. Activation of an EDS1-mediated R-gene pathway in the snc1 mutant leads to constitutive, NPR1-independent pathogen resistance. Li, X., Clarke, J.D., Zhang, Y., Dong, X. Mol. Plant Microbe Interact. (2001) [Pubmed]
  2. A putative nucleoporin 96 Is required for both basal defense and constitutive resistance responses mediated by suppressor of npr1-1,constitutive 1. Zhang, Y., Li, X. Plant Cell (2005) [Pubmed]
  3. A haplotype-specific Resistance gene regulated by BONZAI1 mediates temperature-dependent growth control in Arabidopsis. Yang, S., Hua, J. Plant Cell (2004) [Pubmed]
  4. The C2 domain protein BAP1 negatively regulates defense responses in Arabidopsis. Yang, H., Li, Y., Hua, J. Plant J. (2006) [Pubmed]
  5. The BON/CPN gene family represses cell death and promotes cell growth in Arabidopsis. Yang, S., Yang, H., Grisafi, P., Sanchatjate, S., Fink, G.R., Sun, Q., Hua, J. Plant J. (2006) [Pubmed]
  6. A gain-of-function mutation in a plant disease resistance gene leads to constitutive activation of downstream signal transduction pathways in suppressor of npr1-1, constitutive 1. Zhang, Y., Goritschnig, S., Dong, X., Li, X. Plant Cell (2003) [Pubmed]
  7. Clathrin-Mediated Constitutive Endocytosis of PIN Auxin Efflux Carriers in Arabidopsis. Dhonukshe, P., Aniento, F., Hwang, I., Robinson, D.G., Mravec, J., Stierhof, Y.D., Friml, J. Curr. Biol. (2007) [Pubmed]
  8. Cell death and salicylate- and jasmonate-dependent stress responses in Arabidopsis are controlled by single cet genes. Nibbe, M., Hilpert, B., Wasternack, C., Miersch, O., Apel, K. Planta (2002) [Pubmed]
  9. Production of reactive oxygen species and reactive nitrogen species by angiosperm stigmas and pollen: potential signalling crosstalk? McInnis, S.M., Desikan, R., Hancock, J.T., Hiscock, S.J. New Phytol. (2006) [Pubmed]
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