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MEKK1  -  mitogen-activated protein kinase kinase...

Arabidopsis thaliana

Synonyms: ARAKIN, ATMEKK1, MAPK/ERK kinase kinase 1, MAPKKK8, T15F16.5, ...
 
 
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High impact information on MEKK1

  • In Arabidopsis protoplasts, MKK2 was specifically activated by cold and salt stress and by the stress-induced MAPK kinase kinase MEKK1 [1].
  • MEKK1 Is Required for MPK4 Activation and Regulates Tissue-specific and Temperature-dependent Cell Death in Arabidopsis [2].
  • We show here that MEKK1 is not required for flagellin-triggered activation of MPK3 and MPK6 [2].
  • These results suggest the presence of AtMEKK1-AtMEK1 pathway induced by wounding [3].
  • We have constructed a series of deletion mutants of Arabidopsis MAPK kinase kinase (AtMEKK1) and obtained a constitutively active mutant, AtMEKK1Delta166, which lacks in self-inhibitory sequence of N-terminal 166 amino acids but still has substrate specificity [3].
 

Biological context of MEKK1

  • Overall, our data defines MPK4 as downstream target of MEKK1 and show that MEKK1 functions in integrating ROS homeostasis with plant development and hormone signaling [4].
  • Therefore, we propose that the A. thaliana ATMEKK1 may be a part of the signal transduction pathway involved in osmotic stress [5].
  • Characterisation of novel plant genes encoding MEKK/STE11 and RAF-related protein kinases [6].
 

Associations of MEKK1 with chemical compounds

  • MEKK1 kinase activity and protein stability was regulated by H(2)O(2) in a proteasome-dependent manner and mekk1 plants were compromised in ROS-induced MAPK MPK4 activation [4].
  • Enhanced glycerol production, observed in non-stressed cells expressing ATMEKK1 is the probable cause of yeast survival [5].
 

Other interactions of MEKK1

  • Coexpression of the N-terminal deletion form of ATMEKK1 increased the ability of MEK1 to suppress a growth defect of the yeast pbs2delta mutant [7].
  • In two-hybrid screening using ATMEKK1 as bait, we isolated a novel MAPKK homologue, ATMKK2, a MAPK homologue, ATMPK4, and an unknown protein [8].
  • One is the two-hybrid screening of ATMEKK1 (a MAPKKK)-interacting proteins; the other is an analysis of physical and functional interactions among isolated MAPK, MAPKK, and MAPKKK homologues from Arabidopsis [8].

References

  1. The MKK2 pathway mediates cold and salt stress signaling in Arabidopsis. Teige, M., Scheikl, E., Eulgem, T., Dóczi, R., Ichimura, K., Shinozaki, K., Dangl, J.L., Hirt, H. Mol. Cell (2004) [Pubmed]
  2. MEKK1 Is Required for MPK4 Activation and Regulates Tissue-specific and Temperature-dependent Cell Death in Arabidopsis. Ichimura, K., Casais, C., Peck, S.C., Shinozaki, K., Shirasu, K. J. Biol. Chem. (2006) [Pubmed]
  3. Activation of Arabidopsis MAPK kinase kinase (AtMEKK1) and induction of AtMEKK1-AtMEK1 pathway by wounding. Hadiarto, T., Nanmori, T., Matsuoka, D., Iwasaki, T., Sato, K., Fukami, Y., Azuma, T., Yasuda, T. Planta (2006) [Pubmed]
  4. A Mitogen-activated Protein Kinase Kinase Kinase Mediates Reactive Oxygen Species Homeostasis in Arabidopsis. Nakagami, H., Soukupov??, H., Schikora, A., Z??rsky, V., Hirt, H. J. Biol. Chem. (2006) [Pubmed]
  5. Functional characterization of ARAKIN (ATMEKK1): a possible mediator in an osmotic stress response pathway in higher plants. Covic, L., Silva, N.F., Lew, R.R. Biochim. Biophys. Acta (1999) [Pubmed]
  6. Characterisation of novel plant genes encoding MEKK/STE11 and RAF-related protein kinases. Jouannic, S., Hamal, A., Leprince, A.S., Tregear, J.W., Kreis, M., Henry, Y. Gene (1999) [Pubmed]
  7. Identification of a possible MAP kinase cascade in Arabidopsis thaliana based on pairwise yeast two-hybrid analysis and functional complementation tests of yeast mutants. Mizoguchi, T., Ichimura, K., Irie, K., Morris, P., Giraudat, J., Matsumoto, K., Shinozaki, K. FEBS Lett. (1998) [Pubmed]
  8. Isolation of ATMEKK1 (a MAP kinase kinase kinase)-interacting proteins and analysis of a MAP kinase cascade in Arabidopsis. Ichimura, K., Mizoguchi, T., Irie, K., Morris, P., Giraudat, J., Matsumoto, K., Shinozaki, K. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
 
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