The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

TIR  -  toll/interleukin-1 receptor-like protein

Arabidopsis thaliana

Synonyms: AtTN10, F3N23.13, F3N23_13, TIR-nucleotide binding site family 10, TN10, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of TIR

  • We tested the ability of TIR and coiled-coil-class (also known as leucine-zipper-class) R genes to confer resistance to Pseudomonas syringae pv. tomato or Peronospora parasitica in SA-depleted (NahG) and nim1/npr1 plants [1].
 

High impact information on TIR

  • In addition, a truncated RPS4-Ler transgene encoding the putative TIR and NBS domains was not sufficient to confer resistance, suggesting that the combined presence of regular and alternative RPS4 transcripts is necessary for function [2].
  • P2 is a member of a small multigene family and encodes a protein with nucleotide binding site (NBS) and leucine-rich repeat (LRR) domains and an N-terminal Toll/interleukin-1 receptor (TIR) homology domain, as well as a C-terminal non-LRR (CNL) domain of approximately 150 amino acids [3].
  • They are now known to occur in several organisms, with the most TIR proteins being found in ARABIDOPSIS: our analysis of the sequenced Arabidopsis genome has revealed the presence of at least 135 proteins containing TIR domains [4].
  • Taken together, these results indicate that YkB acts to block AUX/IAA protein degradation upstream of AXR and TIR, links a shared element upstream of AUX/IAA protein stability to auxin-induced cell division/elongation and to auxin-binding protein 1, and provides a new tool to dissect auxin signal transduction [5].
  • The Toll/interleukin-1 receptor (TIR) domain is found in one of the two large families of homologues of plant disease resistance proteins (R proteins) in Arabidopsis and other dicotyledonous plants [6].
 

Biological context of TIR

  • Several novel types of TIR-domain-containing proteins are found in Arabidopsis that are not found in other genomes [4].
  • Deletion analyses of RPS4 domains show the TIR domain is required for the HR phenotype [7].
  • These data are consistent with the hypothesis that at least in Arabidopsis, SA accumulation is necessary for the majority of R-gene-triggered resistance, while the role of NIM1/NPR in race-specific resistance is limited to resistance to P. parasitica mediated by TIR-class R genes [1].
  • With one exception (GAV-3), the deduced amino acid sequences of strawberry RGAs showed strong similarity to TIR (Toll Interleukin I Receptor)-type R genes from Arabidopsis, tobacco and flax, suggesting the existence of common ancestors [8].
 

Other interactions of TIR

  • Incomplete splicing of the RPS4 mRNA was observed, which may give rise to truncated protein products consisting mainly of the TIR and NBS domains [9].

References

  1. Role of salicylic acid and NIM1/NPR1 in race-specific resistance in arabidopsis. Rairdan, G.J., Delaney, T.P. Genetics (2002) [Pubmed]
  2. RPS4-mediated disease resistance requires the combined presence of RPS4 transcripts with full-length and truncated open reading frames. Zhang, X.C., Gassmann, W. Plant Cell (2003) [Pubmed]
  3. Six amino acid changes confined to the leucine-rich repeat beta-strand/beta-turn motif determine the difference between the P and P2 rust resistance specificities in flax. Dodds, P.N., Lawrence, G.J., Ellis, J.G. Plant Cell (2001) [Pubmed]
  4. Toll and interleukin-1 receptor (TIR) domain-containing proteins in plants: a genomic perspective. Jebanathirajah, J.A., Peri, S., Pandey, A. Trends Plant Sci. (2002) [Pubmed]
  5. Yokonolide B, a novel inhibitor of auxin action, blocks degradation of AUX/IAA factors. Hayashi, K., Jones, A.M., Ogino, K., Yamazoe, A., Oono, Y., Inoguchi, M., Kondo, H., Nozaki, H. J. Biol. Chem. (2003) [Pubmed]
  6. TIR-X and TIR-NBS proteins: two new families related to disease resistance TIR-NBS-LRR proteins encoded in Arabidopsis and other plant genomes. Meyers, B.C., Morgante, M., Michelmore, R.W. Plant J. (2002) [Pubmed]
  7. Expression of RPS4 in tobacco induces an AvrRps4-independent HR that requires EDS1, SGT1 and HSP90. Zhang, Y., Dorey, S., Swiderski, M., Jones, J.D. Plant J. (2004) [Pubmed]
  8. Isolation and diversity analysis of resistance gene analogues (RGAs) from cultivated and wild strawberries. Martínez Zamora, M.G., Castagnaro, A.P., Díaz Ricci, J.C. Mol. Genet. Genomics (2004) [Pubmed]
  9. The Arabidopsis RPS4 bacterial-resistance gene is a member of the TIR-NBS-LRR family of disease-resistance genes. Gassmann, W., Hinsch, M.E., Staskawicz, B.J. Plant J. (1999) [Pubmed]
 
WikiGenes - Universities