The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SHM1  -  serine transhydroxymethyltransferase 1

Arabidopsis thaliana

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SHM1

  • Expression of wild-type SHM1 under the control of either the cauliflower mosaic virus 35S or the SHM1 promoter in shm1-1 abrogated the photorespiratory phenotype of the shm mutant, whereas overexpression of SHM2 or expression of SHM1 under the control of the SHM2 promoter did not rescue the mutant phenotype [1].

High impact information on SHM1

  • The compartmentation of FPGS isoforms is in agreement with the predominance of gamma-glutamyl-conjugated tetrahydrofolate derivatives and the presence of serine hydroxymethyltransferase and C1-tetrahydrofolate interconverting enzymes in the cytosol, the mitochondria, and the plastids [2].
  • These results indicate that the stm phenotype is sensitive to the levels of CLV activity, while the clv phenotype is sensitive to the level of STM activity [3].
  • These data establish that 5-CHO-THF can inhibit SHMT in vivo and thereby influence glycine pool size [4].
  • However, the near-normal growth of the mutant shows that even exceptionally high 5-CHO-THF levels do not much affect fluxes through SHMT or any other folate-dependent reaction, i.e. that 5-CHO-THF is well tolerated in plants [4].
  • Because 5-FCL is mitochondrial in plants and mitochondrial SHMT is central to photorespiration, we examined the impact of an insertional mutation in the Arabidopsis 5-FCL gene (At5g13050) under photorespiratory (30 and 370 micromol of CO2 mol(-1)) and non-photorespiratory (3200 micromol of CO2 mol(-1)) conditions [4].

Biological context of SHM1

  • In addition, we show that SHM1 mRNA accumulates in light-grown seedlings, although this response is probably an indirect consequence of the induction of photosynthesis and photorespiration by illumination [5].
  • A T-DNA insertion allele of SHM1, shm1-2, and the F1 progeny of a genetic cross between shm1-1 and shm1-2 displayed the same conditional lethal phenotype as shm1-1 [1].
  • The Arabidopsis genome harbors seven putative SHM genes, two of which (SHM1 and SHM2) feature predicted mitochondrial targeting signals [1].

Associations of SHM1 with chemical compounds


Physical interactions of SHM1


Regulatory relationships of SHM1

  • We examined mRNA accumulation for two of these family members, including one probable photorespiratory gene (SHM1) and a second gene expressed maximally in roots (SHM4), and show that both exhibit circadian oscillations in mRNA abundance that are in phase with those described for other photorespiratory genes [5].


  1. The photorespiratory Arabidopsis shm1 mutant is deficient in SHM1. Voll, L.M., Jamai, A., Renné, P., Voll, H., McClung, C.R., Weber, A.P. Plant Physiol. (2006) [Pubmed]
  2. Tetrahydrofolate biosynthesis in plants: molecular and functional characterization of dihydrofolate synthetase and three isoforms of folylpolyglutamate synthetase in Arabidopsis thaliana. Ravanel, S., Cherest, H., Jabrin, S., Grunwald, D., Surdin-Kerjan, Y., Douce, R., Rébeillé, F. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  3. The CLAVATA and SHOOT MERISTEMLESS loci competitively regulate meristem activity in Arabidopsis. Clark, S.E., Jacobsen, S.E., Levin, J.Z., Meyerowitz, E.M. Development (1996) [Pubmed]
  4. 5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves. Goyer, A., Collakova, E., Díaz de la Garza, R., Quinlivan, E.P., Williamson, J., Gregory, J.F., Shachar-Hill, Y., Hanson, A.D. J. Biol. Chem. (2005) [Pubmed]
  5. Integrated temporal regulation of the photorespiratory pathway. Circadian regulation of two Arabidopsis genes encoding serine hydroxymethyltransferase. McClung, C.R., Hsu, M., Painter, J.E., Gagne, J.M., Karlsberg, S.D., Salomé, P.A. Plant Physiol. (2000) [Pubmed]
  6. Photosynthesis and fluorescence quenching, and the mRNA levels of plastidic glutamine synthetase or of mitochondrial serine hydroxymethyltransferase (SHMT) in the leaves of the wild-type and of the SHMT-deficient stm mutant of Arabidopsis thaliana in relation to the rate of photorespiration. Beckmann, K., Dzuibany, C., Biehler, K., Fock, H., Hell, R., Migge, A., Becker, T.W. Planta (1997) [Pubmed]
  7. Effects of sulfanilamide and methotrexate on 13C fluxes through the glycine decarboxylase/serine hydroxymethyltransferase enzyme system in arabidopsis. Prabhu, V., Chatson, K.B., Lui, H., Abrams, G.D., King, J. Plant Physiol. (1998) [Pubmed]
  8. Arabidopsis photorespiratory serine hydroxymethyltransferase activity requires the mitochondrial accumulation of ferredoxin-dependent glutamate synthase. Jamai, A., Salomé, P.A., Schilling, S.H., Weber, A.P., McClung, C.R. Plant. Cell (2009) [Pubmed]
WikiGenes - Universities