Gene Review:
ERG6 - sterol 24-C-methyltransferase
Saccharomyces cerevisiae S288c
Synonyms:
Delta(24)-sterol C-methyltransferase, ISE1, LIS1, SED6, Sterol 24-C-methyltransferase, ...
- Sterol specificity of the Saccharomyces cerevisiae ERG6 gene product expressed in Escherichia coli. Venkatramesh, M., Guo, D.A., Harman, J.G., Nes, W.D. Lipids (1996)
- The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol. Gaber, R.F., Copple, D.M., Kennedy, B.K., Vidal, M., Bard, M. Mol. Cell. Biol. (1989)
- Deletion of the Hsp70 chaperone gene SSB causes hypersensitivity to guanidine toxicity and curing of the [PSI+] prion by increasing guanidine uptake in yeast. Jones, G.W., Song, Y., Masison, D.C. Mol. Genet. Genomics (2003)
- NudEL targets dynein to microtubule ends through LIS1. Li, J., Lee, W.L., Cooper, J.A. Nat. Cell Biol. (2005)
- Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane. Umebayashi, K., Nakano, A. J. Cell Biol. (2003)
- The LIS1-related NUDF protein of Aspergillus nidulans interacts with the coiled-coil domain of the NUDE/RO11 protein. Efimov, V.P., Morris, N.R. J. Cell Biol. (2000)
- Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae. Young, L.Y., Hull, C.M., Heitman, J. Antimicrob. Agents Chemother. (2003)
- A specific structural requirement for ergosterol in long-chain fatty acid synthesis mutants important for maintaining raft domains in yeast. Eisenkolb, M., Zenzmaier, C., Leitner, E., Schneiter, R. Mol. Biol. Cell (2002)
- Transcriptional response pathways in a yeast strain sensitive to saframycin a and a more potent analog: evidence for a common basis of activity. Plowright, A.T., Schaus, S.E., Myers, A.G. Chem. Biol. (2002)
- A genetic analysis of glucocorticoid receptor signaling. Identification and characterization of ligand-effect modulators in Saccharomyces cerevisiae. Sitcheran, R., Emter, R., Kralli, A., Yamamoto, K.R. Genetics (2000)
- Enhanced membrane fusion in sterol-enriched vacuoles bypasses the Vrp1p requirement. Tedrick, K., Trischuk, T., Lehner, R., Eitzen, G. Mol. Biol. Cell (2004)
- Cloning of S-adenosyl-L-methionine:C-24-Delta-sterol-methyltransferase (ERG6) from Leishmania donovani and characterization of mRNAs in wild-type and amphotericin B-Resistant promastigotes. Pourshafie, M., Morand, S., Virion, A., Rakotomanga, M., Dupuy, C., Loiseau, P.M. Antimicrob. Agents Chemother. (2004)
- Slow diffusion of proteins in the yeast plasma membrane allows polarity to be maintained by endocytic cycling. Valdez-Taubas, J., Pelham, H.R. Curr. Biol. (2003)
- Erg28p is a key protein in the yeast sterol biosynthetic enzyme complex. Mo, C., Bard, M. J. Lipid Res. (2005)
- A yeast sterol auxotroph (erg25) is rescued by addition of azole antifungals and reduced levels of heme. Gachotte, D., Pierson, C.A., Lees, N.D., Barbuch, R., Koegel, C., Bard, M. Proc. Natl. Acad. Sci. U.S.A. (1997)
- A simple method for the isolation of zymosterol from a sterol mutant of Saccharomyces cerevisiae. Heiderpriem, R.W., Livant, P.D., Parish, E.J., Barbuch, R.J., Broaddus, M.G., Bard, M. J. Steroid Biochem. Mol. Biol. (1992)
- Overexpression, purification, and stereochemical studies of the recombinant (S)-adenosyl-L-methionine: delta 24(25)- to delta 24(28)-sterol methyl transferase enzyme from Saccharomyces cerevisiae. Nes, W.D., McCourt, B.S., Zhou, W.X., Ma, J., Marshall, J.A., Peek, L.A., Brennan, M. Arch. Biochem. Biophys. (1998)
- The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p). Mo, C., Valachovic, M., Bard, M. Biochim. Biophys. Acta (2004)
- Genome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol. Bammert, G.F., Fostel, J.M. Antimicrob. Agents Chemother. (2000)
- ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. Emter, R., Heese-Peck, A., Kralli, A. FEBS Lett. (2002)
- Yeast Saccharomyces cerevisiae has two cis-prenyltransferases with different properties and localizations. Implication for their distinct physiological roles in dolichol synthesis. Sato, M., Fujisaki, S., Sato, K., Nishimura, Y., Nakano, A. Genes Cells (2001)