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Gene Review

TOR  -  serine/threonine-protein kinase TOR

Arabidopsis thaliana

Synonyms: F2J10.19, F2J10_19, target of rapamycin
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High impact information on TOR


Biological context of TOR


Associations of TOR with chemical compounds

  • The RAPTOR/KOG1 proteins are binding partners of the target of rapamycin (TOR) kinase that is present in all eucaryotes and plays a central role in the stimulation of cell growth and metabolism in response to nutrients [7].

Physical interactions of TOR

  • Furthermore, pull-down assays demonstrated that TOR binds FKBP12 in the presence of rapamycin [3].

Other interactions of TOR

  • However, Arabidopsis seedlings do not respond to normal physiological levels of rapamycin, which appears to be due its inability to bind to the Arabidopsis homolog of FKBP12, a protein that is essential for the binding of rapamycin with TOR [1].
  • Identification of AML1 as a putative downstream effector of TOR gives valuable insights into the plant-specific mode of action of this critical growth regulator [5].
  • The macrolide rapamycin specifically binds the 12-kD FK506-binding protein (FKBP12), and this complex potently inhibits the target of rapamycin (TOR) kinase [3].


  1. Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals. Mahfouz, M.M., Kim, S., Delauney, A.J., Verma, D.P. Plant Cell (2006) [Pubmed]
  2. Expression and disruption of the Arabidopsis TOR (target of rapamycin) gene. Menand, B., Desnos, T., Nussaume, L., Berger, F., Bouchez, D., Meyer, C., Robaglia, C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Inhibition of target of rapamycin signaling by rapamycin in the unicellular green alga Chlamydomonas reinhardtii. Crespo, J.L., Díaz-Troya, S., Florencio, F.J. Plant Physiol. (2005) [Pubmed]
  4. Plant growth and the TOR pathway. Menand, B., Meyer, C., Robaglia, C. Curr. Top. Microbiol. Immunol. (2004) [Pubmed]
  5. The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue of a major regulator of eukaryotic cell growth. Anderson, G.H., Hanson, M.R. BMC Plant Biol. (2005) [Pubmed]
  6. The Arabidopsis homolog of yeast TAP42 and mammalian alpha4 binds to the catalytic subunit of protein phosphatase 2A and is induced by chilling. Harris, D.M., Myrick, T.L., Rundle, S.J. Plant Physiol. (1999) [Pubmed]
  7. An Arabidopsis homolog of RAPTOR/KOG1 is essential for early embryo development. Deprost, D., Truong, H.N., Robaglia, C., Meyer, C. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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