Gene Review:
FKBP1A - FK506 binding protein 1A, 12kDa
Homo sapiens
Synonyms:
12 kDa FK506-binding protein, 12 kDa FKBP, Calstabin-1, FK506-binding protein 1A, FKBP-12, ...
- The specific FKBP38 inhibitor N-(N',N'-dimethylcarboxamidomethyl)cycloheximide has potent neuroprotective and neurotrophic properties in brain ischemia. Edlich, F., Weiwad, M., Wildemann, D., Jarczowski, F., Kilka, S., Moutty, M.C., Jahreis, G., Lücke, C., Schmidt, W., Striggow, F., Fischer, G. J. Biol. Chem. (2006)
- The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy. Gerard, M., Debyser, Z., Desender, L., Kahle, P.J., Baert, J., Baekelandt, V., Engelborghs, Y. FASEB J. (2006)
- Molecular cloning and overexpression of the human FK506-binding protein FKBP. Standaert, R.F., Galat, A., Verdine, G.L., Schreiber, S.L. Nature (1990)
- Activation of Ca2+ signaling in neutrophils by the mast cell-released immunophilin FKBP12. Bang, H., Müller, W., Hans, M., Brune, K., Swandulla, D. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Nucleotide sequence analysis of the binding site on the inositol 1,4,5-trisphosphate type-1 receptor in bipolar disorder -- a negative study. Fujimaki, K., Morinobu, S., Takahashi, J., Yamawaki, S., Kato, N., Kanno, M., Okuyama, N., Kawakatsu, S., Otani, K., Kusumi, I., Koyama, T. Journal of affective disorders. (2001)
- Golgi membranes remain segregated from the endoplasmic reticulum during mitosis in mammalian cells. Pecot, M.Y., Malhotra, V. Cell (2004)
- Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12. Huse, M., Chen, Y.G., Massagué, J., Kuriyan, J. Cell (1999)
- Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Ranganathan, R., Lu, K.P., Hunter, T., Noel, J.P. Cell (1997)
- Peptidyl-prolyl cis-trans isomerase of Bacillus subtilis: identification of residues involved in cyclosporin A affinity and catalytic efficiency. Göthel, S.F., Herrler, M., Marahiel, M.A. Biochemistry (1996)
- Treatment of normal skeletal muscle with FK506 or rapamycin results in halothane-induced muscle contracture. Brooksbank, R.L., Badenhorst, M.E., Isaacs, H., Savage, N. Anesthesiology (1998)
- Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Heitman, J., Movva, N.R., Hall, M.N. Science (1991)
- An FKBP12 binding assay based upon biotinylated FKBP12. Carreras, C.W., Fu, H., Santi, D.V. Anal. Biochem. (2001)
- An immunophilin that binds M(r) 90,000 heat shock protein: main structural features of a mammalian p59 protein. Callebaut, I., Renoir, J.M., Lebeau, M.C., Massol, N., Burny, A., Baulieu, E.E., Mornon, J.P. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein. Koltin, Y., Faucette, L., Bergsma, D.J., Levy, M.A., Cafferkey, R., Koser, P.L., Johnson, R.K., Livi, G.P. Mol. Cell. Biol. (1991)
- FKBP12 binding modulates ryanodine receptor channel gating. Gaburjakova, M., Gaburjakova, J., Reiken, S., Huang, F., Marx, S.O., Rosemblit, N., Marks, A.R. J. Biol. Chem. (2001)
- Dysregulated ryanodine receptors mediate cellular toxicity: restoration of normal phenotype by FKBP12.6. George, C.H., Higgs, G.V., Mackrill, J.J., Lai, F.A. J. Biol. Chem. (2003)
- Cloning and characterization of chloroplast and cytosolic forms of cyclophilin from Arabidopsis thaliana. Lippuner, V., Chou, I.T., Scott, S.V., Ettinger, W.F., Theg, S.M., Gasser, C.S. J. Biol. Chem. (1994)
- cDNA cloning of a putative protochordate FK506-binding protein. Pancer, Z., Gershon, H., Rinkevich, B. Biochem. Biophys. Res. Commun. (1993)
- FKBP binding characteristics of cardiac microsomes from diverse vertebrates. Jeyakumar, L.H., Ballester, L., Cheng, D.S., McIntyre, J.O., Chang, P., Olivey, H.E., Rollins-Smith, L., Barnett, J.V., Murray, K., Xin, H.B., Fleischer, S. Biochem. Biophys. Res. Commun. (2001)
- FK506 and the role of immunophilins in nerve regeneration. Gold, B.G. Mol. Neurobiol. (1997)
- Expression of FKBP12 and ryanodine receptors (RyRs) in the spinal cord of MND patients. Kihira, T., Utunomiya, H., Kondo, T. Amyotroph. Lateral Scler. Other Motor Neuron Disord. (2005)
- The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different. Bultynck, G., Rossi, D., Callewaert, G., Missiaen, L., Sorrentino, V., Parys, J.B., De Smedt, H. J. Biol. Chem. (2001)
- Energetic and structural analysis of the role of tryptophan 59 in FKBP12. Fulton, K.F., Jackson, S.E., Buckle, A.M. Biochemistry (2003)
- A novel human gene FKBP6 is deleted in Williams syndrome. Meng, X., Lu, X., Morris, C.A., Keating, M.T. Genomics (1998)
- Pancreatic and nephrotoxicity of immunomodulator compounds. Hammond, T.G., Kind, C.N. Toxicol. Lett. (1995)
- Cyclophilin A and FKBP12 interact with YY1 and alter its transcriptional activity. Yang, W.M., Inouye, C.J., Seto, E. J. Biol. Chem. (1995)
- C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90. Cheung-Flynn, J., Roberts, P.J., Riggs, D.L., Smith, D.F. J. Biol. Chem. (2003)
- In situ modulation of the human cardiac ryanodine receptor (hRyR2) by FKBP12.6. George, C.H., Sorathia, R., Bertrand, B.M., Lai, F.A. Biochem. J. (2003)
- Intracellular calcium-release channels: regulators of cell life and death. Marks, A.R. Am. J. Physiol. (1997)
- Effects of FK506-binding protein 12 and FK506 on autophosphorylation of epidermal growth factor receptor. Lopez-Ilasaca, M., Schiene, C., Küllertz, G., Tradler, T., Fischer, G., Wetzker, R. J. Biol. Chem. (1998)
- Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. Del Poeta, M., Cruz, M.C., Cardenas, M.E., Perfect, J.R., Heitman, J. Antimicrob. Agents Chemother. (2000)
- Possible involvement of calcineurin in retinoic acid-induced inhibition of leukemic HL-60 cell proliferation. Kihira, H., Hiasa, A., Yamamoto, M., Katayama, N., Kuno, T., Ohtsuka, K., Shiku, H., Nishikawa, M. Int. J. Oncol. (1998)
- Immunophilins, Refsum disease, and lupus nephritis: the peroxisomal enzyme phytanoyl-COA alpha-hydroxylase is a new FKBP-associated protein. Chambraud, B., Radanyi, C., Camonis, J.H., Rajkowski, K., Schumacher, M., Baulieu, E.E. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13. Jin, Y.J., Albers, M.W., Lane, W.S., Bierer, B.E., Schreiber, S.L., Burakoff, S.J. Proc. Natl. Acad. Sci. U.S.A. (1991)
- The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis. Krummrei, U., Baulieu, E.E., Chambraud, B. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Three amino acid residues determine selective binding of FK506-binding protein 12.6 to the cardiac ryanodine receptor. Xin, H.B., Rogers, K., Qi, Y., Kanematsu, T., Fleischer, S. J. Biol. Chem. (1999)
- Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor. Bultynck, G., De Smet, P., Rossi, D., Callewaert, G., Missiaen, L., Sorrentino, V., De Smedt, H., Parys, J.B. Biochem. J. (2001)
- Cyclosporin A, FK-506, and rapamycin: pharmacologic probes of lymphocyte signal transduction. Sigal, N.H., Dumont, F.J. Annu. Rev. Immunol. (1992)
- Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex. Van Duyne, G.D., Standaert, R.F., Karplus, P.A., Schreiber, S.L., Clardy, J. Science (1991)
- A ligand-reversible dimerization system for controlling protein-protein interactions. Rollins, C.T., Rivera, V.M., Woolfson, D.N., Keenan, T., Hatada, M., Adams, S.E., Andrade, L.J., Yaeger, D., van Schravendijk, M.R., Holt, D.A., Gilman, M., Clackson, T. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin. Maki, N., Sekiguchi, F., Nishimaki, J., Miwa, K., Hayano, T., Takahashi, N., Suzuki, M. Proc. Natl. Acad. Sci. U.S.A. (1990)