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Gene Review

ACRBP  -  acrosin binding protein

Homo sapiens

Synonyms: Acrosin-binding protein, CT23, Cancer/testis antigen 23, Cancer/testis antigen OY-TES-1, OY-TES-1, ...
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Disease relevance of ACRBP


High impact information on ACRBP


Anatomical context of ACRBP

  • Thymus and leukocytes were weakly positive for OY-TES-1 while the remaining 5 normal tissues were negative [2].
  • OY-TES-1 expression was determined by one-step reverse transcriptase PCR on 100 EOC samples, 5 EOC cell lines, and a panel of normal tissues [2].
  • Identification of an HLA-A24-restricted OY-TES-1 epitope recognized by cytotoxic T-cells [5].

Analytical, diagnostic and therapeutic context of ACRBP


  1. Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen. Ono, T., Kurashige, T., Harada, N., Noguchi, Y., Saika, T., Niikawa, N., Aoe, M., Nakamura, S., Higashi, T., Hiraki, A., Wada, H., Kumon, H., Old, L.J., Nakayama, E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. OY-TES-1 expression and serum immunoreactivity in epithelial ovarian cancer. Tammela, J., Uenaka, A., Ono, T., Noguchi, Y., Jungbluth, A.A., Mhawech-Fauceglia, P., Qian, F., Schneider, S., Sharma, S., Driscoll, D., Lele, S., Old, L.J., Nakayama, E., Odunsi, K. Int. J. Oncol. (2006) [Pubmed]
  3. Analysis of swinepox virus antigens using monoclonal antibodies. Ouchi, M., Fujiwara, M., Hatano, Y., Yamada, M., Nii, S. J. Vet. Med. Sci. (1992) [Pubmed]
  4. Direct effect of progestogen on gene expression in the testis during gonadotropin withdrawal and early suppression of spermatogenesis. Walton, M.J., Bayne, R.A., Wallace, I., Baird, D.T., Anderson, R.A. J. Clin. Endocrinol. Metab. (2006) [Pubmed]
  5. Identification of an HLA-A24-restricted OY-TES-1 epitope recognized by cytotoxic T-cells. Okumura, H., Noguchi, Y., Uenaka, A., Aji, T., Ono, T., Nakagawa, K., Aoe, M., Shimizu, N., Nakayama, E. Microbiol. Immunol. (2005) [Pubmed]
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