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Gene Review:

EMR3 - egf-like module containing, mucin-like,...

Homo sapiens

Synonyms: EGF-like module receptor 3, EGF-like module-containing mucin-like hormone receptor-like 3, UNQ683/PRO1562

Matmati, M. et al., Stacey, M. et al., Kwakkenbos, M.J. et al., Bjarnadóttir, T.K. et al.

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High impact information on EMR3

As with other members of the EGF-TM7 family, EMR3 mRNA displays a predominantly leukocyte-restricted expression pattern, with highest levels in neutrophils, monocytes, and macrophages [1].
Through the use of soluble EMR3 multivalent probes we have shown the presence of a ligand at the surface of monocyte-derived macrophages and activated human neutrophils [1].
The EMR3 gene maps closely to the existing members of the EGF-TM7 family on human chromosome 19p13.1 and, in common with other EGF-TM7 genes, is capable of generating different protein isoforms through alternative splicing [1].
It is interesting that in contrast with CD97 and EMR2, CD34(+)CD33(-)/CD38(-) committed hematopoietic stem cells and CD34(+)CD33(+)/CD38(+) progenitors in bone marrow do not express EMR3 [2].
In peripheral blood, the highest expression of EMR3 was found on granulocytes [2].

Biological context of EMR3

By comparing EGF-TM7 receptors in primates and dogs, we identified an intriguing pattern of concerted evolution, apparently mediated by gene conversion, among EMR2 and the oppositely orientated and physically adjacent genes CD97 and EMR3 [3].

Anatomical context of EMR3

Flow cytometric analysis revealed that all types of myeloid cells express EMR3 [2].
Lymphocytes and plasmacytoid DC are EMR3(-) [2].
More mature CD16(+) monocytes express high levels of EMR3, and CD16(-) monocytes and myeloid dendritic cells (DC) are EMR3(dim/low) [2].
In vitro differentiation of HL-60 cells and CD34(+) progenitor cells revealed that EMR3 is only up-regulated during late granulopoiesis [2].

Other interactions of EMR3

The mouse and human sequences show a clear one-to-one relationship, with the exception of EMR2 and EMR3, which do not seem to have orthologues in mouse [4].

References

Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. Stacey, M., Lin, H.H., Hilyard, K.L., Gordon, S., McKnight, A.J. J. Biol. Chem. (2001) [Pubmed]
The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. Matmati, M., Pouwels, W., van Bruggen, R., Jansen, M., Hoek, R.M., Verhoeven, A.J., Hamann, J. J. Leukoc. Biol. (2007) [Pubmed]
An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2. Kwakkenbos, M.J., Matmati, M., Madsen, O., Pouwels, W., Wang, Y., Bontrop, R.E., Heidt, P.J., Hoek, R.M., Hamann, J. FASEB J. (2006) [Pubmed]
The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir, T.K., Fredriksson, R., Höglund, P.J., Gloriam, D.E., Lagerström, M.C., Schiöth, H.B. Genomics (2004) [Pubmed]

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