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Gene Review

EMR2  -  egf-like module containing, mucin-like,...

Homo sapiens

Synonyms: CD312, EGF-like module receptor 2, EGF-like module-containing mucin-like hormone receptor-like 2
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Disease relevance of EMR2


High impact information on EMR2


Biological context of EMR2


Anatomical context of EMR2


Associations of EMR2 with chemical compounds


Regulatory relationships of EMR2

  • Although its precise function is unknown, EMR2 is highly expressed in immune tissues and has been shown to weakly bind CD55, a complement-system regulator [11].

Other interactions of EMR2

  • Use of 2A1 has demonstrated EMR2, like CD97, to be expressed as a heterodimeric receptor consisting of an extracellular alpha part and a TM7/cytoplasmic beta part [10].

Analytical, diagnostic and therapeutic context of EMR2


  1. CD97, but not its closely related EGF-TM7 family member EMR2, is expressed on gastric, pancreatic, and esophageal carcinomas. Aust, G., Steinert, M., Schütz, A., Boltze, C., Wahlbuhl, M., Hamann, J., Wobus, M. Am. J. Clin. Pathol. (2002) [Pubmed]
  2. Detection of alternatively spliced EMR2 mRNAs in colorectal tumor cell lines but rare expression of the molecule in colorectal adenocarcinomas. Aust, G., Hamann, J., Schilling, N., Wobus, M. Virchows Arch. (2003) [Pubmed]
  3. The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans. Stacey, M., Chang, G.W., Davies, J.Q., Kwakkenbos, M.J., Sanderson, R.D., Hamann, J., Gordon, S., Lin, H.H. Blood (2003) [Pubmed]
  4. Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif. Lin, H.H., Chang, G.W., Davies, J.Q., Stacey, M., Harris, J., Gordon, S. J. Biol. Chem. (2004) [Pubmed]
  5. The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. Matmati, M., Pouwels, W., van Bruggen, R., Jansen, M., Hoek, R.M., Verhoeven, A.J., Hamann, J. J. Leukoc. Biol. (2007) [Pubmed]
  6. Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells. Kwakkenbos, M.J., Pouwels, W., Matmati, M., Stacey, M., Lin, H.H., Gordon, S., van Lier, R.A., Hamann, J. J. Leukoc. Biol. (2005) [Pubmed]
  7. Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. Lin, H.H., Stacey, M., Hamann, J., Gordon, S., McKnight, A.J. Genomics (2000) [Pubmed]
  8. An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2. Kwakkenbos, M.J., Matmati, M., Madsen, O., Pouwels, W., Wang, Y., Bontrop, R.E., Heidt, P.J., Hoek, R.M., Hamann, J. FASEB J. (2006) [Pubmed]
  9. CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells. Chang, G.W., Davies, J.Q., Stacey, M., Yona, S., Bowdish, D.M., Hamann, J., Chen, T.C., Lin, C.Y., Gordon, S., Lin, H.H. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  10. The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells. Kwakkenbos, M.J., Chang, G.W., Lin, H.H., Pouwels, W., de Jong, E.C., van Lier, R.A., Gordon, S., Hamann, J. J. Leukoc. Biol. (2002) [Pubmed]
  11. Crystallization and preliminary X-ray diffraction analysis of three EGF domains of EMR2, a 7TM immune-system molecule. Abbott, R.J., Knott, V., Roversi, P., Neudeck, S., Lukacik, P., Handford, P.A., Lea, S.M. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
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