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Gene Review

REPS1  -  RALBP1 associated Eps domain containing 1

Homo sapiens

Synonyms: RalBP1-associated Eps domain-containing protein 1, RalBP1-interacting protein 1
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Disease relevance of REPS1

  • DNA 1 is unrelated to AYVV DNA A but resembles nanovirus components that encode Reps and is most closely related (73% identity) to a nanovirus-like DNA recently isolated from geminivirus-infected cotton [1].

High impact information on REPS1

  • PURPOSE: The purpose of this study was to compare the effects of a high-load (80%, 1-repetition maximum (RM), 8 reps) and a high-repetition (40%, 1-RM, 16 reps) resistance training protocol on muscular strength and bone mineral density (BMD) in early postmenopausal, estrogen-deficient women [2].
  • The colonoscope was passed through 1 of 16 study arms (5 reps/arm for a total of 80 runs) that were controlled for all possible combinations of the following variables: manual precleaning; 10-, 20-, or 45-minute glutaraldehyde exposure; air or ethanol drying; or automated reprocessing with peracetic acid (liquid sterilization system) [3].
  • Twelve men performed six sets of five reps of dumbbell exercise of the elbow flexors eccentrically with one arm and concentrically with the other, separated by 4-6 weeks, using a dumbbell set at 50% of maximal voluntary isometric contraction (MVC) measured at 90 degrees of elbow flexion [4].
  • Arterial (brachial artery catheter) and esophageal (probe) pressure responses were measured before and after training as subjects did sets of as many repetitions as possible up to 20 reps with 50, 70, 80, 85 and 87.5% 1-RM [5].
  • In SEQ1, a week of weight maintenance diet and prescribed exercise (3 d.wk-1, 3 sets, approximately 85% 1 RM, 10-12 reps, eight lifts) beginning on d 11 of their menstrual cycle was followed by measurement of hormone response to a weightlifting bout during energy balance (EBAL) on d 18 [6].

Biological context of REPS1

  • When the data from men and women were analyzed separately, blood lactate often made a significant contribution to total energy expenditure for reps to exhaustion (endurance-type training), but this trend was not always statistically evident for the limited reps (strength-type training) protocol [7].

Anatomical context of REPS1

  • Northern blot analysis shows that the REPS1 is expressed in a variety of tissues, with the strongest expression in the heart and testis [8].
  • The net differences (between pre- and posttraining changes) between the CWT and CON groups was statistically significant for VO2max (2.45 ml x min(-1) x kg(-1), 95% CI 1.1; 3.8), for abdominal muscles (3.7 reps, CI 0.3; 7.1), for push-ups (1.1 reps, CI 0.2; 2.1), and for kneeling (2.25 reps, CI 0.01; 4.5) [9].

Analytical, diagnostic and therapeutic context of REPS1

  • Subjects were then randomly assigned to either a high-repetition (three to five sets of 15-20 reps) short-rest (20 s) resistance-training group or to a control group [10].


  1. A nanovirus-like DNA component associated with yellow vein disease of Ageratum conyzoides: evidence for interfamilial recombination between plant DNA viruses. Saunders, K., Stanley, J. Virology (1999) [Pubmed]
  2. Musculoskeletal responses to high- and low-intensity resistance training in early postmenopausal women. Bemben, D.A., Fetters, N.L., Bemben, M.G., Nabavi, N., Koh, E.T. Medicine and science in sports and exercise. (2000) [Pubmed]
  3. Antimicrobial efficacy of endoscopic disinfection procedures: a controlled, multifactorial investigation. Cronmiller, J.R., Nelson, D.K., Salman, G., Jackson, D.K., Dean, R.S., Hsu, J.J., Kim, C.H. Gastrointest. Endosc. (1999) [Pubmed]
  4. Changes in fluctuation of isometric force following eccentric and concentric exercise of the elbow flexors. Lavender, A.P., Nosaka, K. Eur. J. Appl. Physiol. (2006) [Pubmed]
  5. Effect of training on the blood pressure response to weight lifting. Sale, D.G., Moroz, D.E., McKelvie, R.S., MacDougall, J.D., McCartney, N. Canadian journal of applied physiology = Revue canadienne de physiologie appliquée. (1994) [Pubmed]
  6. Response of beta-endorphin and estradiol to resistance exercise in females during energy balance and energy restriction. Walberg-Rankin, J., Franke, W.D., Gwazdauskas, F.C. International journal of sports medicine. (1992) [Pubmed]
  7. Contribution of blood lactate to the energy expenditure of weight training. Scott, C.B. Journal of strength and conditioning research / National Strength & Conditioning Association. (2006) [Pubmed]
  8. Cloning, expression and characterization of a novel human REPS1 gene. Xu, J., Zhou, Z., Zeng, L., Huang, Y., Zhao, W., Cheng, C., Xu, M., Xie, Y., Mao, Y. Biochim. Biophys. Acta (2001) [Pubmed]
  9. The effect of heart rate controlled low resistance circuit weight training and endurance training on maximal aerobic power in sedentary adults. Kaikkonen, H., Yrjämä, M., Siljander, E., Byman, P., Laukkanen, R. Scandinavian journal of medicine & science in sports. (2000) [Pubmed]
  10. Effects of resistance training on h+ regulation, buffer capacity, and repeated sprints. Edge, J., Hill-Haas, S., Goodman, C., Bishop, D. Medicine and science in sports and exercise (2006) [Pubmed]
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