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Chemical Compound Review

PERACETIC ACID     ethaneperoxoic acid

Synonyms: Perasafe, Acecide, Peresal, Proxitane, Tsunami, ...
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Disease relevance of peroxyacetic acid


Psychiatry related information on peroxyacetic acid

  • While many disinfectants, including peracetic acid, have been employed to eradicate infectious bacteria, a lack of understanding their mode of action and the corresponding defense mechanisms hinders successful antimicrobial application [6].

High impact information on peroxyacetic acid


Chemical compound and disease context of peroxyacetic acid


Biological context of peroxyacetic acid


Anatomical context of peroxyacetic acid

  • In addition, we found a significant increase in MN frequency in circulating erythrocytes after 10 days of exposure of fish to water treated with ClO(2), while a non-significant six-fold increase in MN frequency was observed with NaClO, but not with PAA [21].
  • All three disinfectants are weakly genotoxic in human leukocytes (lowest effective dose 0.2 p.p.m. for chlorine dioxide, 0.5 p.p.m. for sodium hypochlorite and peracetic acid) [22].
  • The influence of peracetic acid (PAA) disinfectant on Salmonella enterica serotype Typhimurium LT2 in sewage effluent was examined by studying its ability to adhere to and invade HeLa cells in vitro [23].
  • The efficacy of 0.35% stabilized buffered peracetic acid solution ('Nu-Cidex') against clinical isolates of Mycobacterium tuberculosis, Mycobacterium avium-intracellulare and Mycobacterium chelonae in homogenized sputum was tested [24].
  • In addition, it was found that storage of plasma-treated membrane fragments with peracetic acid abolished neutrophil oxygen radical production [25].

Associations of peroxyacetic acid with other chemical compounds


Gene context of peroxyacetic acid

  • The effects of reprocessing high-flux polysulfone dialyzers with peroxyacetic acid on beta 2-microglobulin removal in hemodiafiltration [31].
  • The present study compared the ball-burst strength of five different ECM scaffolds before and after treatment with peracetic acid (PAA): porcine small intestinal submucosa (SIS), porcine urinary bladder submucosa (UBS), porcine urinary bladder matrix (UBM), a composite of UBS + UBM, and canine stomach submucosa (SS) [32].
  • Our study tested hydrogen peroxide, peracetic acid, and a germicide (Cidex PA, Advanced Sterilization Products, Irvine, Calif) containing a mixture of the 2 peroxygen compounds for their ability to kill both glutaraldehyde-resistant and nonresistant (control) mycobacteria [33].
  • The association of the bacteria with the plant roots resulted in protection of the wild-type as well as the catalase-deficient mutant from killing by peracetic acid [34].
  • Histopathology indicated native and peracetic acid-treated SIS showed no implant mineralization (P < 0.0001) and little peri-implant fibrosis (P < 0.0001) [35].

Analytical, diagnostic and therapeutic context of peroxyacetic acid


  1. EPR and ENDOR detection of compound I from Micrococcus lysodeikticus catalase. Benecky, M.J., Frew, J.E., Scowen, N., Jones, P., Hoffman, B.M. Biochemistry (1993) [Pubmed]
  2. Redox Intermediates in the Catalase Cycle of Catalase-Peroxidases from Synechocystis PCC 6803, Burkholderia pseudomallei, and Mycobacterium tuberculosis. Jakopitsch, C., Vlasits, J., Wiseman, B., Loewen, P.C., Obinger, C. Biochemistry (2007) [Pubmed]
  3. Oxygen toxicity from plants to people. Schloss, J.V. Planta (2002) [Pubmed]
  4. Suitability of peracetic acid for sterilization of media for mycoplasma cultures. Wutzler, P., Sprössig, M., Peterseim, H. J. Clin. Microbiol. (1975) [Pubmed]
  5. Role of Acinetobacter calcoaceticus 3,4-dihydrocoumarin hydrolase in oxidative stress defence against peroxoacids. Honda, K., Kataoka, M., Sakuradani, E., Shimizu, S. Eur. J. Biochem. (2003) [Pubmed]
  6. Microarray analysis of toxicogenomic effects of peracetic acid on Pseudomonas aeruginosa. Chang, W., Small, D.A., Toghrol, F., Bentley, W.E. Environ. Sci. Technol. (2005) [Pubmed]
  7. Effects of hemodialyzer reuse on clearances of urea and beta2-microglobulin. The Hemodialysis (HEMO) Study Group. Cheung, A.K., Agodoa, L.Y., Daugirdas, J.T., Depner, T.A., Gotch, F.A., Greene, T., Levin, N.W., Leypoldt, J.K. J. Am. Soc. Nephrol. (1999) [Pubmed]
  8. Oxidation of cytochrome c peroxidase to compound I by peroxyacids: evidence for rate-limiting diffusion through the protein matrix. Palamakumbura, A.H., Foshay, M.C., Vitello, L.B., Erman, J.E. Biochemistry (1999) [Pubmed]
  9. Enteric lesions and diarrhea in gnotobiotic calves monoinfected with Cryptosporidium species. Heine, J., Pohlenz, J.F., Moon, H.W., Woode, G.N. J. Infect. Dis. (1984) [Pubmed]
  10. Ligand and pH influence on manganese-mediated peracetic acid epoxidation of terminal olefins. Murphy, A., Pace, A., Stack, T.D. Org. Lett. (2004) [Pubmed]
  11. Biofilms and planktonic cells of Pseudomonas aeruginosa have similar resistance to killing by antimicrobials. Spoering, A.L., Lewis, K. J. Bacteriol. (2001) [Pubmed]
  12. Comparison of sodium hypochlorite and peracetic acid as sanitising agents for stainless steel food processing surfaces using epifluorescence microscopy. Rossoni, E.M., Gaylarde, C.C. Int. J. Food Microbiol. (2000) [Pubmed]
  13. Sensitivity of human adenoviruses to different groups of chemical biocides. Sauerbrei, A., Sehr, K., Brandstädt, A., Heim, A., Reimer, K., Wutzler, P. J. Hosp. Infect. (2004) [Pubmed]
  14. Inactivation of Lactobacillus helveticus bacteriophages by thermal and chemical treatments. Quiberoni, A., Suárez, V.B., Reinheimer, J.A. J. Food Prot. (1999) [Pubmed]
  15. Efficacy of disinfectants to reduce Listeria monocytogenes on precut iceberg lettuce. Hellström, S., Kervinen, R., Lyly, M., Ahvenainen-Rantala, R., Korkeala, H. J. Food Prot. (2006) [Pubmed]
  16. A comparison of different chemical sanitizers for inactivating Escherichia coli O157:H7 and Listeria monocytogenes in solution and on apples, lettuce, strawberries, and cantaloupe. Rodgers, S.L., Cash, J.N., Siddiq, M., Ryser, E.T. J. Food Prot. (2004) [Pubmed]
  17. Peracetic acid in the disinfection of a hospital water system contaminated with Legionella species. Ditommaso, S., Biasin, C., Giacomuzzi, M., Zotti, C.M., Cavanna, A., Ruggenini Moiraghi, A. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (2005) [Pubmed]
  18. Use of the Comet test and micronucleus assay on human white blood cells for in vitro assessment of genotoxicity induced by different drinking water disinfection protocols. Maffei, F., Buschini, A., Rossi, C., Poli, P., Forti, G.C., Hrelia, P. Environ. Mol. Mutagen. (2005) [Pubmed]
  19. Reaction mechanism of the Co2+-activated multifunctional bromoperoxidase-esterase from Pseudomonas putida IF-3. Kawanami, T., Miyakoshi, M., Dairi, T., Itoh, N. Arch. Biochem. Biophys. (2002) [Pubmed]
  20. Detection of persistent vegetative bacteria and amplified viral nucleic acid from in-use testing of gastrointestinal endoscopes. Deva, A.K., Vickery, K., Zou, J., West, R.H., Selby, W., Benn, R.A., Harris, J.P., Cossart, Y.E. J. Hosp. Infect. (1998) [Pubmed]
  21. Perturbation of cytochrome P450, generation of oxidative stress and induction of DNA damage in Cyprinus carpio exposed in situ to potable surface water. Sapone, A., Gustavino, B., Monfrinotti, M., Canistro, D., Broccoli, M., Pozzetti, L., Affatato, A., Valgimigli, L., Forti, G.C., Pedulli, G.F., Biagi, G.L., Abdel-Rahman, S.Z., Paolini, M. Mutat. Res. (2007) [Pubmed]
  22. Sodium hypochlorite-, chlorine dioxide- and peracetic acid-induced genotoxicity detected by the Comet assay and Saccharomyces cerevisiae D7 tests. Buschini, A., Carboni, P., Furlini, M., Poli, P., Rossi, C. Mutagenesis (2004) [Pubmed]
  23. Influence of peracetic acid on adhesion/invasion of Salmonella enterica serotype typhimurium LT2. Jolivet-Gougeon, A., Sauvager, F., Arturo-Schaan, M., Bonnaure-Mallet, M., Cormier, M. Cell Biol. Toxicol. (2003) [Pubmed]
  24. Disinfection of bronchoscopes, contaminated in vitro with Mycobacterium tuberculosis, Mycobacterium avium-intracellulare and Mycobacterium chelonae in sputum, using stabilized, buffered peracetic acid solution ('Nu-Cidex'). Middleton, A.M., Chadwick, M.V., Gaya, H. J. Hosp. Infect. (1997) [Pubmed]
  25. Biocompatibility aspects of dialyzer reprocessing: a comparison of 3 re-use methods and 3 membranes. Kuwahara, T., Markert, M., Wauters, J.P. Clin. Nephrol. (1989) [Pubmed]
  26. Analysis of the association of dialyzer reuse practices and patient outcomes. Held, P.J., Wolfe, R.A., Gaylin, D.S., Port, F.K., Levin, N.W., Turenne, M.N. Am. J. Kidney Dis. (1994) [Pubmed]
  27. Two-electron reduction and one-electron oxidation of organic hydroperoxides by human myeloperoxidase. Furtmüller, P.G., Burner, U., Jantschko, W., Regelsberger, G., Obinger, C. FEBS Lett. (2000) [Pubmed]
  28. Disinfection and sterilization of patient-care items. Rutala, W.A. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (1996) [Pubmed]
  29. Modulating effects of humic acids on genotoxicity induced by water disinfectants in Cyprinus carpio. Gustavino, B., Buschini, A., Monfrinotti, M., Rizzoni, M., Tancioni, L., Poli, P., Rossi, C. Mutat. Res. (2005) [Pubmed]
  30. Bactericidal properties of peracetic acid and hydrogen peroxide, alone and in combination, and chlorine and formaldehyde against bacterial water strains. Alasri, A., Roques, C., Michel, G., Cabassud, C., Aptel, P. Can. J. Microbiol. (1992) [Pubmed]
  31. The effects of reprocessing high-flux polysulfone dialyzers with peroxyacetic acid on beta 2-microglobulin removal in hemodiafiltration. Kerr, P.G., Argiles, A., Canaud, B., Flavier, J.L., Mion, C. Am. J. Kidney Dis. (1992) [Pubmed]
  32. Biaxial strength of multilaminated extracellular matrix scaffolds. Freytes, D.O., Badylak, S.F., Webster, T.J., Geddes, L.A., Rundell, A.E. Biomaterials (2004) [Pubmed]
  33. Efficacy of peroxygen compounds against glutaraldehyde-resistant mycobacteria. Stanley, P.M. American journal of infection control. (1999) [Pubmed]
  34. Catalase activity and the survival of Pseudomonas putida, a root colonizer, upon treatment with peracetic acid. Anderson, A.J., Miller, C.D. Can. J. Microbiol. (2001) [Pubmed]
  35. Calcification potential of small intestinal submucosa in a rat subcutaneous model. Owen, T.J., Lantz, G.C., Hiles, M.C., VanVleet, J., Martin, B.R., Geddes, L.A. J. Surg. Res. (1997) [Pubmed]
  36. Nosocomial transmission of imipenem-resistant Pseudomonas aeruginosa following bronchoscopy associated with improper connection to the Steris System 1 processor. Sorin, M., Segal-Maurer, S., Mariano, N., Urban, C., Combest, A., Rahal, J.J. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (2001) [Pubmed]
  37. Determination of gas phase peroxyacetic acid using pre-column derivatization with organic sulfide reagents and liquid chromatography. Effkemann, S., Brødsgaard, S., Mortensen, P., Linde, S.A., Karst, U. Journal of chromatography. A. (1999) [Pubmed]
  38. Technical and economic feasibility of reusing disposable perfusion cannulas. Bloom, D.F., Cornhill, J.F., Malchesky, P.S., Richardson, D.M., Bolsen, K.A., Haire, D.M., Loop, F.D., Cosgrove, D.M. J. Thorac. Cardiovasc. Surg. (1997) [Pubmed]
  39. A survey of reprocessing methods, residual viable bioburden, and soil levels in patient-ready endoscopic retrograde choliangiopancreatography duodenoscopes used in Canadian centers. Alfa, M.J., Olson, N., DeGagne, P., Jackson, M. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (2002) [Pubmed]
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