Gene Review:
SRS2 - Srs2p
Saccharomyces cerevisiae S288c
Synonyms:
ATP-dependent DNA helicase SRS2, HPR5, J0913, RADH, YJL092W
- The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. McVey, M., Kaeberlein, M., Tissenbaum, H.A., Guarente, L. Genetics (2001)
- Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae. Rong, L., Klein, H.L. J. Biol. Chem. (1993)
- Metabolic suppressors of trimethoprim and ultraviolet light sensitivities of Saccharomyces cerevisiae rad6 mutants. Lawrence, C.W., Christensen, R.B. J. Bacteriol. (1979)
- The dynamics of homologous pairing during mating type interconversion in budding yeast. Houston, P.L., Broach, J.R. PLoS Genet. (2006)
- The possible roles of the DNA helicase and C-terminal domains in RECQ5/QE: complementation study in yeast. Nakayama, M., Kawasaki, K., Matsumoto, K., Shibata, T. DNA Repair (Amst.) (2004)
- DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray. Ooi, S.L., Shoemaker, D.D., Boeke, J.D. Nat. Genet. (2003)
- Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Ira, G., Malkova, A., Liberi, G., Foiani, M., Haber, J.E. Cell (2003)
- DNA helicase Srs2 disrupts the Rad51 presynaptic filament. Krejci, L., Van Komen, S., Li, Y., Villemain, J., Reddy, M.S., Klein, H., Ellenberger, T., Sung, P. Nature (2003)
- The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene. Rong, L., Palladino, F., Aguilera, A., Klein, H.L. Genetics (1991)
- Mrc1 is required for sister chromatid cohesion to aid in recombination repair of spontaneous damage. Xu, H., Boone, C., Klein, H.L. Mol. Cell. Biol. (2004)
- POL32, a subunit of the Saccharomyces cerevisiae DNA polymerase delta, defines a link between DNA replication and the mutagenic bypass repair pathway. Huang, M.E., de Calignon, A., Nicolas, A., Galibert, F. Curr. Genet. (2000)
- Semidominant mutations in the yeast Rad51 protein and their relationships with the Srs2 helicase. Chanet, R., Heude, M., Adjiri, A., Maloisel, L., Fabre, F. Mol. Cell. Biol. (1996)
- SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase. Pfander, B., Moldovan, G.L., Sacher, M., Hoege, C., Jentsch, S. Nature (2005)
- Srs2 DNA helicase is involved in checkpoint response and its regulation requires a functional Mec1-dependent pathway and Cdk1 activity. Liberi, G., Chiolo, I., Pellicioli, A., Lopes, M., Plevani, P., Muzi-Falconi, M., Foiani, M. EMBO J. (2000)
- Genetic and molecular analysis of recombination events in Saccharomyces cerevisiae occurring in the presence of the hyper-recombination mutation hpr1. Aguilera, A., Klein, H.L. Genetics (1989)
- Suppression of spontaneous genome rearrangements in yeast DNA helicase mutants. Schmidt, K.H., Kolodner, R.D. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51. Milne, G.T., Ho, T., Weaver, D.T. Genetics (1995)
- A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio. Wilson, T.E. Genetics (2002)
- Genetic interactions between mutants of the 'error-prone' repair group of Saccharomyces cerevisiae and their effect on recombination and mutagenesis. Liefshitz, B., Steinlauf, R., Friedl, A., Eckardt-Schupp, F., Kupiec, M. Mutat. Res. (1998)
- The human F-Box DNA helicase FBH1 faces Saccharomyces cerevisiae Srs2 and postreplication repair pathway roles. Chiolo, I., Saponaro, M., Baryshnikova, A., Kim, J.H., Seo, Y.S., Liberi, G. Mol. Cell. Biol. (2007)