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Gene Review

RFC5  -  replication factor C subunit 5

Saccharomyces cerevisiae S288c

Synonyms: Activator 1 40 kDa subunit, Replication factor C subunit 5, Replication factor C5, YBR0810, YBR087W
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Disease relevance of RFC5


High impact information on RFC5


Biological context of RFC5


Associations of RFC5 with chemical compounds


Other interactions of RFC5

  • Our results, together with the observation that overexpression of RAD53 suppresses the defects of the rfc5-1 mutation, suggest that Rfc5 is part of a mechanism transducing the DNA damage signal to the activation of the central transducer Rad53 [6].


  1. Identification of the fifth subunit of Saccharomyces cerevisiae replication factor C. Gary, S.L., Burgers, M.J. Nucleic Acids Res. (1995) [Pubmed]
  2. LCD1: an essential gene involved in checkpoint control and regulation of the MEC1 signalling pathway in Saccharomyces cerevisiae. Rouse, J., Jackson, S.P. EMBO J. (2000) [Pubmed]
  3. Rfc5, a small subunit of replication factor C complex, couples DNA replication and mitosis in budding yeast. Sugimoto, K., Shimomura, T., Hashimoto, K., Araki, H., Sugino, A., Matsumoto, K. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  4. Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae. Kim, H.S., Brill, S.J. Mol. Cell. Biol. (2001) [Pubmed]
  5. Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae. Naiki, T., Shimomura, T., Kondo, T., Matsumoto, K., Sugimoto, K. Mol. Cell. Biol. (2000) [Pubmed]
  6. Rfc5, a replication factor C component, is required for regulation of Rad53 protein kinase in the yeast checkpoint pathway. Sugimoto, K., Ando, S., Shimomura, T., Matsumoto, K. Mol. Cell. Biol. (1997) [Pubmed]
  7. Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways. Shimomura, T., Ando, S., Matsumoto, K., Sugimoto, K. Mol. Cell. Biol. (1998) [Pubmed]
  8. Allele-specific interactions between the yeast RFC1 and RFC5 genes suggest a basis for RFC subunit-subunit interactions. Beckwith, W., McAlear, M.A. Mol. Gen. Genet. (2000) [Pubmed]
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