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Gene Review

RAD24  -  Rad24p

Saccharomyces cerevisiae S288c

Synonyms: Checkpoint protein RAD24, SYGP-ORF60, YER173W
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High impact information on RAD24

  • Rad17 and Rad24 proteins may contribute directly to formation of an arrest signal by association with single-strand DNA in mitosis and meiosis [1].
  • Second, mec1 and rad24 single mutants (DMC1+) appear to undergo MI before all recombination events are complete [1].
  • Ddc1 association required Rad24 but not Mec1 or Rad9 [2].
  • An assay that measures DNA damage processing in vivo showed that the checkpoint genes RAD17, RAD24, and MEC3 activated an exonuclease that degrades DNA [3].
  • Elg1 is redundant with Rad24 in the DNA damage response and contributes to activation of the checkpoint kinase Rad53 [4].

Biological context of RAD24


Associations of RAD24 with chemical compounds


Physical interactions of RAD24


Regulatory relationships of RAD24

  • RAD24 overexpression suppresses the sensitivity of rfc5-1 cells to DNA-damaging agents and the defect in DNA damage-induced Rad53 phosphorylation [11].
  • Finally, analysis of double mutants suggests a minor role for Mec1 in promoting Rad24-dependent degradation of dsDNA [12].

Other interactions of RAD24


Analytical, diagnostic and therapeutic context of RAD24


  1. A meiotic recombination checkpoint controlled by mitotic checkpoint genes. Lydall, D., Nikolsky, Y., Bishop, D.K., Weinert, T. Nature (1996) [Pubmed]
  2. Recruitment of Mec1 and Ddc1 checkpoint proteins to double-strand breaks through distinct mechanisms. Kondo, T., Wakayama, T., Naiki, T., Matsumoto, K., Sugimoto, K. Science (2001) [Pubmed]
  3. Yeast checkpoint genes in DNA damage processing: implications for repair and arrest. Lydall, D., Weinert, T. Science (1995) [Pubmed]
  4. Elg1 forms an alternative RFC complex important for DNA replication and genome integrity. Bellaoui, M., Chang, M., Ou, J., Xu, H., Boone, C., Brown, G.W. EMBO J. (2003) [Pubmed]
  5. Rfc5, in cooperation with rad24, controls DNA damage checkpoints throughout the cell cycle in Saccharomyces cerevisiae. Naiki, T., Shimomura, T., Kondo, T., Matsumoto, K., Sugimoto, K. Mol. Cell. Biol. (2000) [Pubmed]
  6. Chl12 (Ctf18) forms a novel replication factor C-related complex and functions redundantly with Rad24 in the DNA replication checkpoint pathway. Naiki, T., Kondo, T., Nakada, D., Matsumoto, K., Sugimoto, K. Mol. Cell. Biol. (2001) [Pubmed]
  7. RAD9, RAD17, and RAD24 are required for S phase regulation in Saccharomyces cerevisiae in response to DNA damage. Paulovich, A.G., Margulies, R.U., Garvik, B.M., Hartwell, L.H. Genetics (1997) [Pubmed]
  8. G2/M checkpoint genes of Saccharomyces cerevisiae: further evidence for roles in DNA replication and/or repair. Lydall, D., Weinert, T. Mol. Gen. Genet. (1997) [Pubmed]
  9. Repair of 6-4 photoproducts and cyclobutane pyrimidine dimers in rad mutants of Saccharomyces cerevisiae. McCready, S. Mutat. Res. (1994) [Pubmed]
  10. A novel Rad24 checkpoint protein complex closely related to replication factor C. Green, C.M., Erdjument-Bromage, H., Tempst, P., Lowndes, N.F. Curr. Biol. (2000) [Pubmed]
  11. Functional and physical interaction between Rad24 and Rfc5 in the yeast checkpoint pathways. Shimomura, T., Ando, S., Matsumoto, K., Sugimoto, K. Mol. Cell. Biol. (1998) [Pubmed]
  12. Mec1 and Rad53 inhibit formation of single-stranded DNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants. Jia, X., Weinert, T., Lydall, D. Genetics (2004) [Pubmed]
  13. The mitotic DNA damage checkpoint proteins Rad17 and Rad24 are required for repair of double-strand breaks during meiosis in yeast. Shinohara, M., Sakai, K., Ogawa, T., Shinohara, A. Genetics (2003) [Pubmed]
  14. Rfc4 interacts with Rpa1 and is required for both DNA replication and DNA damage checkpoints in Saccharomyces cerevisiae. Kim, H.S., Brill, S.J. Mol. Cell. Biol. (2001) [Pubmed]
  15. RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation. de la Torre-Ruiz, M.A., Green, C.M., Lowndes, N.F. EMBO J. (1998) [Pubmed]
  16. HRad17, a human homologue of the Schizosaccharomyces pombe checkpoint gene rad17, is overexpressed in colon carcinoma. Bao, S., Chang, M.S., Auclair, D., Sun, Y., Wang, Y., Wong, W.K., Zhang, J., Liu, Y., Qian, X., Sutherland, R., Magi-Galluzi, C., Weisberg, E., Cheng, E.Y., Hao, L., Sasaki, H., Campbell, M.S., Kraeft, S.K., Loda, M., Lo, K.M., Chen, L.B. Cancer Res. (1999) [Pubmed]
  17. Dmc1 of Schizosaccharomyces pombe plays a role in meiotic recombination. Fukushima, K., Tanaka, Y., Nabeshima, K., Yoneki, T., Tougan, T., Tanaka, S., Nojima, H. Nucleic Acids Res. (2000) [Pubmed]
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