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Gene Review

Plcb2  -  phospholipase C, beta 2

Rattus norvegicus

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2, PLC-beta-2, Phosphoinositide phospholipase C-beta-2, Phospholipase C-beta-2
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Disease relevance of Plcb2


High impact information on Plcb2


Chemical compound and disease context of Plcb2

  • Calcitriol increases InsP(3) formation via activation of phospholipase C (PLC)-beta1 linked to a pertussis toxin (PTX)-insensitive G-protein, and estradiol via activation of PLC-beta2 linked to a PTX-sensitive G-protein [5].

Biological context of Plcb2


Anatomical context of Plcb2


Associations of Plcb2 with chemical compounds

  • This bitter agent elicited a rapid and transient increase of the inositol 1,4,5-trisphosphate level; this response was blocked by U73122, a potent inhibitor of PLC, and by PLC beta2-specific antibodies [6].

Other interactions of Plcb2


  1. Phospholipase C beta and membrane action of calcitriol and estradiol. Le Mellay, V., Grosse, B., Lieberherr, M. J. Biol. Chem. (1997) [Pubmed]
  2. Requirement of aldose reductase for the hyperglycemic activation of protein kinase C and formation of diacylglycerol in vascular smooth muscle cells. Ramana, K.V., Friedrich, B., Tammali, R., West, M.B., Bhatnagar, A., Srivastava, S.K. Diabetes (2005) [Pubmed]
  3. Activation of phospholipase C isozymes by G protein beta gamma subunits. Park, D., Jhon, D.Y., Lee, C.W., Lee, K.H., Rhee, S.G. J. Biol. Chem. (1993) [Pubmed]
  4. Phospholipase C beta 2 in vascular smooth muscle. LaBelle, E.F., Polyák, F. J. Cell. Physiol. (1996) [Pubmed]
  5. Galpha(q/11) and gbetagamma proteins and membrane signaling of calcitriol and estradiol. Le Mellay, V., Lasmoles, F., Lieberherr, M. J. Cell. Biochem. (1999) [Pubmed]
  6. Identification of a phospholipase C beta subtype in rat taste cells. Rössler, P., Kroner, C., Freitag, J., Noè, J., Breer, H. Eur. J. Cell Biol. (1998) [Pubmed]
  7. CCK, carbachol, and bombesin activate distinct PLC-beta isoenzymes via Gq/11 in rat pancreatic acinar membranes. Piiper, A., Stryjek-Kaminska, D., Klengel, R., Zeuzem, S. Am. J. Physiol. (1997) [Pubmed]
  8. Identification and characterization of a specific sensory epithelium in the rat larynx. Sbarbati, A., Merigo, F., Benati, D., Tizzano, M., Bernardi, P., Crescimanno, C., Osculati, F. J. Comp. Neurol. (2004) [Pubmed]
  9. Phosphatidylinositol-specific phospholipase C isoform expression in pregnant and nonpregnant rat myometrial tissue. Bieber, E., Stratman, T., Sanseverino, M., Sangueza, J., Phillippe, M. Am. J. Obstet. Gynecol. (1998) [Pubmed]
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