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Gene Review

Plcb1  -  phospholipase C, beta 1 (phosphoinositide...

Rattus norvegicus

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1, PLC'1, PLC-154, PLC-I, PLC-beta-1, ...
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Disease relevance of Plcb1


High impact information on Plcb1

  • Those of PLC-I and III were short and appeared to be unrelated to these tyrosine kinases [5].
  • Here, phospholipase C-related cDNA clones corresponding to PLC-I and PLC-III were isolated from a rat brain lambda gt11 expression cDNA library using specific monoclonal antibodies and sequenced [5].
  • Cytosolic phosphatidylinositol transfer protein (PITP) is necessary for guanosine triphosphate (GTP)-dependent hydrolysis of PIP2 by phospholipase C-beta (PLC-beta), but the role of PITP is unclear [6].
  • M(1) muscarinic (M(1)AChRs) and B(2) bradykinin (B(2)Rs) receptors are two PLCbeta-coupled receptors that mobilize Ca(2+) in nonexcitable cells [7].
  • In contrast, NE also increased PLC beta 1 but did not affect PLC gamma 1 protein expression in membranes [8].

Chemical compound and disease context of Plcb1

  • The association of PLC-beta1 and Gi/o-type G proteins was studied by pertussis toxin-catalyzed [32P]adenosine diphosphate ribosylation of PLC-beta1 immunoprecipitates [9].
  • Applied as a model substance for the stimulation of the phosphoinositide-phospholipase C pathway, angiotensin II has been used to simulate the bronchospasm of smooth muscle in asthma [10].
  • These receptors are coupled to phospholipase C beta and to dihydropyridine-sensitive calcium channels via heterotrimeric G proteins differing by their sensitivities to pertussis toxin [11].

Biological context of Plcb1


Anatomical context of Plcb1


Associations of Plcb1 with chemical compounds


Regulatory relationships of Plcb1


Other interactions of Plcb1


Analytical, diagnostic and therapeutic context of Plcb1


  1. Phospholipase C beta and membrane action of calcitriol and estradiol. Le Mellay, V., Grosse, B., Lieberherr, M. J. Biol. Chem. (1997) [Pubmed]
  2. Bradykinin, but not muscarinic, inhibition of M-current in rat sympathetic ganglion neurons involves phospholipase C-beta 4. Haley, J.E., Abogadie, F.C., Fernandez-Fernandez, J.M., Dayrell, M., Vallis, Y., Buckley, N.J., Brown, D.A. J. Neurosci. (2000) [Pubmed]
  3. Cross-talk between receptor-mediated phospholipase C-beta and D via protein kinase C as intracellular signal possibly leading to hypertrophy in serum-free cultured cardiomyocytes. Eskildsen-Helmond, Y.E., Bezstarosti, K., Dekkers, D.H., van Heugten, H.A., Lamers, J.M. J. Mol. Cell. Cardiol. (1997) [Pubmed]
  4. Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction. Ju, H., Zhao, S., Tappia, P.S., Panagia, V., Dixon, I.M. Circulation (1998) [Pubmed]
  5. Cloning and sequence of multiple forms of phospholipase C. Suh, P.G., Ryu, S.H., Moon, K.H., Suh, H.W., Rhee, S.G. Cell (1988) [Pubmed]
  6. Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling. Kauffmann-Zeh, A., Thomas, G.M., Ball, A., Prosser, S., Cunningham, E., Cockcroft, S., Hsuan, J.J. Science (1995) [Pubmed]
  7. Signaling microdomains define the specificity of receptor-mediated InsP(3) pathways in neurons. Delmas, P., Wanaverbecq, N., Abogadie, F.C., Mistry, M., Brown, D.A. Neuron (2002) [Pubmed]
  8. Differential regulation of renal phospholipase C isoforms by catecholamines. Yu, P.Y., Asico, L.D., Eisner, G.M., Jose, P.A. J. Clin. Invest. (1995) [Pubmed]
  9. Epidermal growth factor inhibits bombesin-induced activation of phospholipase C-beta1 in rat pancreatic acinar cells. Piiper, A., Stryjek-Kaminska, D., Klengel, R., Zeuzem, S. Gastroenterology (1997) [Pubmed]
  10. Simultaneous measurement of Ca2+ transients and changes in the cell volume and microviscosity of the plasma membrane in smooth muscle cells. Evaluation of the effect of formoterol. Ochsner, M. Biochem. Pharmacol. (1996) [Pubmed]
  11. Vasopressin regulates adrenal functions by acting through different vasopressin receptor subtypes. Grazzini, E., Boccara, G., Joubert, D., Trueba, M., Durroux, T., Guillon, G., Gallo-Payet, N., Chouinard, L., Payet, M.D., Serradeil Le Gal, C. Adv. Exp. Med. Biol. (1998) [Pubmed]
  12. Stimulation of G-protein coupled receptors in vascular smooth muscle cells induces tyrosine kinase dependent increases in calcium without tyrosine phosphorylation of phospholipase C gamma-1. Di Salvo, J., Raatz Nelson, S. FEBS Lett. (1998) [Pubmed]
  13. Identification of a phospholipase C beta subtype in rat taste cells. Rössler, P., Kroner, C., Freitag, J., Noè, J., Breer, H. Eur. J. Cell Biol. (1998) [Pubmed]
  14. Two forms of phospholipase C-beta 1 generated by alternative splicing. Bahk, Y.Y., Lee, Y.H., Lee, T.G., Seo, J., Ryu, S.H., Suh, P.G. J. Biol. Chem. (1994) [Pubmed]
  15. The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal. Hwang, J.I., Kim, H.S., Lee, J.R., Kim, E., Ryu, S.H., Suh, P.G. J. Biol. Chem. (2005) [Pubmed]
  16. Phospholipase C beta 2 in vascular smooth muscle. LaBelle, E.F., Polyák, F. J. Cell. Physiol. (1996) [Pubmed]
  17. Transmembrane signaling through phospholipase C in cortical and hippocampal membranes of psychogenetically selected rat lines. Sallés, J., López de Jesús, M., Goñi, O., Fernández-Teruel, A., Driscoll, P., Tobeña, A., Escorihuela, R.M. Psychopharmacology (Berl.) (2001) [Pubmed]
  18. Distributional patterns of phospholipase C isozymes in rat pancreas. Kim, M.J., Lee, K.H., Min, D.S., Yoon, S.H., Hahn, S.J., Kim, M.S., Jo, Y.H. Pancreas (2001) [Pubmed]
  19. Membrane signaling and progesterone in female and male osteoblasts. II. Direct involvement of G alpha q/11 coupled to PLC-beta 1 and PLC-beta 3. Le Mellay, V., Lieberherr, M. J. Cell. Biochem. (2000) [Pubmed]
  20. CCK, carbachol, and bombesin activate distinct PLC-beta isoenzymes via Gq/11 in rat pancreatic acinar membranes. Piiper, A., Stryjek-Kaminska, D., Klengel, R., Zeuzem, S. Am. J. Physiol. (1997) [Pubmed]
  21. Temporal dispersion of activation of phospholipase C-beta1 and -gamma isoforms by angiotensin II in vascular smooth muscle cells. Role of alphaq/11, alpha12, and beta gamma G protein subunits. Ushio-Fukai, M., Griendling, K.K., Akers, M., Lyons, P.R., Alexander, R.W. J. Biol. Chem. (1998) [Pubmed]
  22. Fibroblast growth factor-2 stimulates phospholipase Cbeta in adult cardiomyocytes. Tappia, P.S., Padua, R.R., Panagia, V., Kardami, E. Biochem. Cell Biol. (1999) [Pubmed]
  23. Endothelin-1-induced phospholipase C-beta and D and protein kinase C isoenzyme signaling leading to hypertrophy in rat cardiomyocytes. Lamers, J.M., Eskildsen-Helmond, Y.E., Resink, A.M., de Jonge, H.W., Bezstarosti, K., Sharma, H.S., van Heugten, H.A. J. Cardiovasc. Pharmacol. (1995) [Pubmed]
  24. Identification of three phospholipase C isotypes expressed in rat olfactory epithelium. Bruch, R.C., Abogadie, F.C., Farbman, A.I. Neuroreport (1995) [Pubmed]
  25. Thyrotropin-releasing hormone-induced down-regulation of pyroglutamyl aminopeptidase II activity involves L-type calcium channels and cam kinase activities in cultures of adenohypophyseal cells. Vargas, M.A., Cisneros, M., Joseph-Bravo, P., Charli, J.L. J. Neuroendocrinol. (2002) [Pubmed]
  26. PACAP and VIP stimulate Ca2+ oscillations in rat gonadotrophs through the PACAP/VIP type 1 receptor (PVR1) linked to a pertussis toxin-insensitive G-protein and the activation of phospholipase C-beta. Hezareh, M., Schlegel, W., Rawlings, S.R. J. Neuroendocrinol. (1996) [Pubmed]
  27. PKC isoforms and other signaling proteins involved in surfactant secretion in developing rat type II cells. Gobran, L.I., Xu, Z.X., Rooney, S.A. Am. J. Physiol. (1998) [Pubmed]
  28. Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells. Marrero, M.B., Paxton, W.G., Duff, J.L., Berk, B.C., Bernstein, K.E. J. Biol. Chem. (1994) [Pubmed]
  29. Immunohistochemical expressions of mGluR5, P2Y2 receptor, PLC-beta1, and IP3R-I and -II in Merkel cells in rat sinus hair follicles. Tachibana, T., Endoh, M., Kumakami, R., Nawa, T. Histochem. Cell Biol. (2003) [Pubmed]
  30. Gastrin induces IP3 formation through phospholipase C gamma 1 and pp60c-src kinase. Yassin, R.R., Abrams, J.T. Peptides (1998) [Pubmed]
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