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Gene Review

Plcb3  -  phospholipase C, beta 3...

Rattus norvegicus

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3, PLC-beta-3, Phosphoinositide phospholipase C-beta-3, Phospholipase C-beta-3
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Disease relevance of Plcb3


High impact information on Plcb3

  • Increased expression of phospholipase C (PLC)-beta1 and PLC-beta3 proteins was apparent in the scar and viable tissues after MI versus controls and is associated with increased PLC-beta1 activity in experimental hearts [5].
  • The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal [6].
  • Importantly, microinjection of a synthetic peptide specifically mimicking the C terminus of PLC-beta3 markedly reduces the mGluR-mediated intracellular calcium response [6].
  • Homer 1b, a Shank-interacting protein that is linked to group I metabotropic glutamate receptors and IP3 receptors, forms a multiple complex with Shank2 and PLC-beta3 [6].
  • CXCR2 and the mutant 331T induced phospholipase C beta3 phosphorylation to an extent equivalent to that of CXCR1 [7].

Biological context of Plcb3

  • With the use of antibodies raised against synthetic peptides corresponding to PLC-beta 3-specific amino acid sequences, we purified PLC-beta 3 from a rat brain particulate fraction [8].
  • The increased muscle mass as well as the mRNA levels for PLC beta1 and beta3 in atria and RV, unlike PLC beta3 gene expression in LV, at 3 days of AVshunt were attenuated by losartan [3].
  • These results suggest that the extracellular signals that induce the dissociation of G(o) or Gi, the heterotrimeric G proteins abundant in brain, should enhance the hydrolysis of PtdIns 4,5-P2 in brain primarily through activation of PLC-beta 3 (PLC-beta 2 is not detectable in brain) [9].
  • The upregulation of G alpha q/11, PLC beta 3 and ERK1/2 in NRVMs occurred prior to [(3)H]-leucine incorporation increases, and could be inhibited with losartan [10].
  • CONCLUSION: AngII can initiate cardiac hypertrophy and upregulate signal molecules in the G alpha q/11-mediated signal transduction pathway, such as G alpha q/11, PLC beta 3 and ERK1/2, at both tissue and cellular levels [10].

Anatomical context of Plcb3


Associations of Plcb3 with chemical compounds


Physical interactions of Plcb3


Other interactions of Plcb3


Analytical, diagnostic and therapeutic context of Plcb3


  1. The 5'-upstream region of the rat phospholipase C-beta 3 gene contains two critical Sp1 sites and an HIV Inr-like element. Kang, J.S., Lee, H.B., Rhee, S.G., Park, K., Yoo, O.J. Gene (1997) [Pubmed]
  2. Membrane signaling and progesterone in female and male osteoblasts. II. Direct involvement of G alpha q/11 coupled to PLC-beta 1 and PLC-beta 3. Le Mellay, V., Lieberherr, M. J. Cell. Biochem. (2000) [Pubmed]
  3. Losartan attenuates phospholipase C isozyme gene expression in hypertrophied hearts due to volume overload. Dent, M.R., Aroutiounova, N., Dhalla, N.S., Tappia, P.S. J. Cell. Mol. Med. (2006) [Pubmed]
  4. Suppression of the neoplastic phenotype by transfection of phospholipase C beta 3 to neuroendocrine tumor cells. Stålberg, P., Wang, S., Larsson, C., Weber, G., Oberg, K., Gobl, A., Skogseid, B. FEBS Lett. (1999) [Pubmed]
  5. Expression of Gq alpha and PLC-beta in scar and border tissue in heart failure due to myocardial infarction. Ju, H., Zhao, S., Tappia, P.S., Panagia, V., Dixon, I.M. Circulation (1998) [Pubmed]
  6. The interaction of phospholipase C-beta3 with Shank2 regulates mGluR-mediated calcium signal. Hwang, J.I., Kim, H.S., Lee, J.R., Kim, E., Ryu, S.H., Suh, P.G. J. Biol. Chem. (2005) [Pubmed]
  7. Differential cross-regulation of the human chemokine receptors CXCR1 and CXCR2. Evidence for time-dependent signal generation. Richardson, R.M., Pridgen, B.C., Haribabu, B., Ali, H., Snyderman, R. J. Biol. Chem. (1998) [Pubmed]
  8. Cloning, sequencing, purification, and Gq-dependent activation of phospholipase C-beta 3. Jhon, D.Y., Lee, H.H., Park, D., Lee, C.W., Lee, K.H., Yoo, O.J., Rhee, S.G. J. Biol. Chem. (1993) [Pubmed]
  9. Activation of phospholipase C isozymes by G protein beta gamma subunits. Park, D., Jhon, D.Y., Lee, C.W., Lee, K.H., Rhee, S.G. J. Biol. Chem. (1993) [Pubmed]
  10. Angiotensin II induced upregulation of G alpha q/11, phospholipase C beta 3 and extracellular signal-regulated kinase 1/2 via angiotensin II type 1 receptor. Bai, H., Wu, L.L., Xing, D.Q., Liu, J., Zhao, Y.L. Chin. Med. J. (2004) [Pubmed]
  11. Transmembrane signaling through phospholipase C in cortical and hippocampal membranes of psychogenetically selected rat lines. Sallés, J., López de Jesús, M., Goñi, O., Fernández-Teruel, A., Driscoll, P., Tobeña, A., Escorihuela, R.M. Psychopharmacology (Berl.) (2001) [Pubmed]
  12. Phosphatidylinositol-specific phospholipase C isoform expression in pregnant and nonpregnant rat myometrial tissue. Bieber, E., Stratman, T., Sanseverino, M., Sangueza, J., Phillippe, M. Am. J. Obstet. Gynecol. (1998) [Pubmed]
  13. Protein expression of phospholipase C in pregnant and nonpregnant rat uterine tissue. Kim, T.T., Saunders, T., Bieber, E., Phillippe, M. Am. J. Obstet. Gynecol. (2001) [Pubmed]
  14. Decreased m3-muscarinic and alpha 1-adrenergic receptor stimulation of PIP2 hydrolysis in parotid gland membranes from aged rats: defect in activation of G alpha q/11. Sawaki, K., Baum, B.J., Roth, G.S., Ambudkar, I.S. Arch. Biochem. Biophys. (1995) [Pubmed]
  15. Increased expression of Galpha(q/11) and of phospholipase-Cbeta1/4 in differentiated human NT2-N neurons: enhancement of phosphoinositide hydrolysis. Novak, J.E., Agranoff, B.W., Fisher, S.K. J. Neurochem. (2000) [Pubmed]
  16. Carbachol-induced desensitization of PLC-beta pathway in rat myometrium: downregulation of Gqalpha/G11alpha. Lajat, S., Harbon, S., Tanfin, Z. Am. J. Physiol. (1998) [Pubmed]
  17. PKC isoforms and other signaling proteins involved in surfactant secretion in developing rat type II cells. Gobran, L.I., Xu, Z.X., Rooney, S.A. Am. J. Physiol. (1998) [Pubmed]
  18. Attenuation of renomedullary phospholipase C isozyme, PLC-delta 1, in spontaneously hypertensive rats. Lee, K.H., Cho, Y.J., Cha, S.H., Endou, H. Biochem. Mol. Biol. Int. (1997) [Pubmed]
  19. 1alpha,25(OH)2D3 causes a rapid increase in phosphatidylinositol-specific PLC-beta activity via phospholipase A2-dependent production of lysophospholipid. Schwartz, Z., Shaked, D., Hardin, R.R., Gruwell, S., Dean, D.D., Sylvia, V.L., Boyan, B.D. Steroids (2003) [Pubmed]
  20. Gastrin induces IP3 formation through phospholipase C gamma 1 and pp60c-src kinase. Yassin, R.R., Abrams, J.T. Peptides (1998) [Pubmed]
  21. Defective sarcolemmal phospholipase C signaling in diabetic cardiomyopathy. Tappia, P.S., Asemu, G., Aroutiounova, N., Dhalla, N.S. Mol. Cell. Biochem. (2004) [Pubmed]
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