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Gene Review

CTP1  -  Ctp1p

Saccharomyces cerevisiae S288c

Synonyms: CTP, Citrate transport protein, Tricarboxylate transport protein, YBR2039, YBR291C
 
 
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Disease relevance of CTP1

 

High impact information on CTP1

 

Biological context of CTP1

 

Associations of CTP1 with chemical compounds

  • The mitochondrial citrate transport protein (CTP) has been investigated by replacing 22 consecutive residues within transmembrane domain IV, one at a time, with cysteine [3].
  • Ca(2+)- and citrate transport were found to be maximal at this growth phase [9].
  • The mitochondrial citrate transport protein: Evidence for a steric interaction between glutamine 182 and leucine 120 and its relationship to the substrate translocation pathway and identification of other mechanistically essential residues [10].
  • Previous examination of the accessibility of a panel of single-Cys mutants in transmembrane domain III (TMDIII) of the yeast mitochondrial citrate transport protein to the hydrophilic, cysteine-specific methanethiosulfonate reagent MTSES enabled identification of the water-accessible surface of this TMD [10].
 

Other interactions of CTP1

  • The stable yeast deletion strain was constructed by homologous recombination of the HIS3 gene at the CTP1 gene locus [7].
 

Analytical, diagnostic and therapeutic context of CTP1

References

  1. High level expression and characterization of the mitochondrial citrate transport protein from the yeast Saccharomyces cerevisiae. Kaplan, R.S., Mayor, J.A., Gremse, D.A., Wood, D.O. J. Biol. Chem. (1995) [Pubmed]
  2. The yeast mitochondrial citrate transport protein. Probing the roles of cysteines, Arg(181), and Arg(189) in transporter function. Xu, Y., Kakhniashvili, D.A., Gremse, D.A., Wood, D.O., Mayor, J.A., Walters, D.E., Kaplan, R.S. J. Biol. Chem. (2000) [Pubmed]
  3. The yeast mitochondrial citrate transport protein. Probing the secondary structure of transmembrane domain iv and identification of residues that likely comprise a portion of the citrate translocation pathway. Kaplan, R.S., Mayor, J.A., Brauer, D., Kotaria, R., Walters, D.E., Dean, A.M. J. Biol. Chem. (2000) [Pubmed]
  4. Cooperation between enzyme and transporter in the inner mitochondrial membrane of yeast. Requirement for mitochondrial citrate synthase for citrate and malate transport in Saccharomyces cerevisiae. Sandor, A., Johnson, J.H., Srere, P.A. J. Biol. Chem. (1994) [Pubmed]
  5. The yeast mitochondrial citrate transport protein: determination of secondary structure and solvent accessibility of transmembrane domain IV using site-directed spin labeling. Kaplan, R.S., Mayor, J.A., Kotaria, R., Walters, D.E., McHaourab, H.S. Biochemistry (2000) [Pubmed]
  6. Analysis of the secondary structure of the cys-less yeast mitochondrial citrate transport protein and four single-cys variants by circular dichroism. Cascio, M., Mayor, J.A., Kaplan, R.S. J. Bioenerg. Biomembr. (2004) [Pubmed]
  7. Deletion of the nuclear gene encoding the mitochondrial citrate transport protein from Saccharomyces cerevisiae. Kaplan, R.S., Mayor, J.A., Kakhniashvili, D., Gremse, D.A., Wood, D.O., Nelson, D.R. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  8. The sequence of a 32,420 bp segment located on the right arm of chromosome II from Saccharomyces cerevisiae. Holmstrøm, K., Brandt, T., Kallesøe, T. Yeast (1994) [Pubmed]
  9. Change in transport activities of vacuoles of the yeast Yarrowia lipolytica during its growth on glucose. Kulakovskaya, T.V., Matyashova, R.N., Shishkanova, N.V., Finogenova, T.V., Okorokov, L.A. Yeast (1993) [Pubmed]
  10. The mitochondrial citrate transport protein: Evidence for a steric interaction between glutamine 182 and leucine 120 and its relationship to the substrate translocation pathway and identification of other mechanistically essential residues. Ma, C., Remani, S., Kotaria, R., Mayor, J.A., Walters, D.E., Kaplan, R.S. Biochim. Biophys. Acta (2006) [Pubmed]
 
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