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Gene Review

PSMA6  -  proteasome (prosome, macropain) subunit,...

Homo sapiens

Synonyms: 27 kDa prosomal protein, IOTA, MGC22756, MGC2333, MGC23846, ...
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Disease relevance of PSMA6

  • A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population [1].
  • 15N relaxation measurements have been performed on the type Iota blue copper protein azurin from Pseudomonas aeruginosa [2].
  • The present study was an initial investigation of the vowel space area formed by the lax vowels /Iota/, /varepsilon/, and /upsilon/, occurring in a passage read in habitual, fast, and slow conditions by speakers with amyotrophic lateral sclerosis (ALS), speakers with Parkinson's disease (PD), and healthy controls [3].

High impact information on PSMA6

  • Moreover, suppression of PSMA6 expression using short interfering RNA in cultured cells reduced activation of the transcription factor NF-kappaB by stabilizing phosphorylated IkappaB [1].
  • Interestingly, the lymphocyte subpopulations most strongly labeled by the anti-p25K and anti-p27K mAbs were the NK and B cells [4].
  • While the C2-I component of C2 toxin was translocated into the cytosol from early endosomes, translocation of the Ia component of Iota toxin occurred between early and late endosomes, was dependent on more acidic conditions, and uniquely required a membrane potential gradient [5].
  • Differential requirement for the translocation of clostridial binary toxins: Iota toxin requires a membrane potential gradient [5].
  • The genes Hs PROS-27 and Hs PROS-30 were mapped to chromosomes 14 (14q13) and 11 (11p15.1), respectively [6].

Biological context of PSMA6

  • The structure of the p27K protein shows multiple potential phosphorylation sites, an NTP-binding fold and an RNA-binding consensus sequence [6].
  • Conclusion The reported genotype in PSMA6 appears not to contribute appreciably to MI, but may contribute slightly to atherosclerosis in the present study population [7].
  • A TG dinucleotide repeat was identified in intron 6 of the human proteasome core particle PROS-27K (IOTA, PSMA6) gene [8].
  • Compound 4 showed significant inhibition against topoisomerase Iota with an IC50 value of 0.8 microM [9].
  • Exon/intron organisation of human proteasome PROS-27 K gene [10].

Anatomical context of PSMA6

  • The Hs PROS-27/beta-galactosidase fusion protein binds a single RNA of about 120 nucleotides from total HeLa cell RNA [6].
  • The clostridial binary toxins (Iota and C2 families) ADP-ribosylate the actin monomers causing the dissociation of the actin filaments [11].

Other interactions of PSMA6

  • Sequence comparisons show that the Hs PROS-27 and Hs PROS-30 genes belong to the gene family that encodes the prosome--MCP (multicatalytic proteinase)--proteasome proteins [6].

Analytical, diagnostic and therapeutic context of PSMA6

  • The presence and relative amounts of prosome subunits were analyzed by flow cytometry, light and fluorescent microscopy and Western blotting using 3 monoclonal antibodies (p25K, p27K and p30-33K MAbs) [12].
  • The transplanted kidney graft showed well-preserved glomeruli and tubules, corresponding to chronic allograft nephropathy (CAN) grade Iota (ci1, ct1, cv1), according to the Banff classification [13].
  • Background Recently, a large case-control study (2,851 cases and 2,592 controls) reported that a functional single nuclear polymorphism (SNP) in the proteasome subunit alpha type 6 gene (PSMA6) conferred a risk of myocardial infarction (MI) in a Japanese population [7].


  1. A functional SNP in PSMA6 confers risk of myocardial infarction in the Japanese population. Ozaki, K., Sato, H., Iida, A., Mizuno, H., Nakamura, T., Miyamoto, Y., Takahashi, A., Tsunoda, T., Ikegawa, S., Kamatani, N., Hori, M., Nakamura, Y., Tanaka, T. Nat. Genet. (2006) [Pubmed]
  2. Backbone dynamics of azurin in solution: slow conformational change associated with deprotonation of histidine 35. Kalverda, A.P., Ubbink, M., Gilardi, G., Wijmenga, S.S., Crawford, A., Jeuken, L.J., Canters, G.W. Biochemistry (1999) [Pubmed]
  3. Characteristics of the lax vowel space in dysarthria. Tjaden, K., Rivera, D., Wilding, G., Turner, G.S. J. Speech Lang. Hear. Res. (2005) [Pubmed]
  4. Characterization of prosomes in human lymphocyte subpopulations and their presence as surface antigens. Bureau, J.P., Olink-Coux, M., Brouard, N., Bayle-Julien, S., Huesca, M., Herzberg, M., Scherrer, K. Exp. Cell Res. (1997) [Pubmed]
  5. Differential requirement for the translocation of clostridial binary toxins: Iota toxin requires a membrane potential gradient. Gibert, M., Marvaud, J.C., Pereira, Y., Hale, M.L., Stiles, B.G., Boquet, P., Lamaze, C., Popoff, M.R. FEBS Lett. (2007) [Pubmed]
  6. The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family. Bey, F., Silva Pereira, I., Coux, O., Viegas-Péquignot, E., Recillas Targa, F., Nothwang, H.G., Dutrillaux, B., Scherrer, K. Mol. Gen. Genet. (1993) [Pubmed]
  7. Validation of the Association Between the Gene Encoding Proteasome Subunit alpha Type 6 and Myocardial Infarction in a Japanese Population. Takashima, N., Shioji, K., Kokubo, Y., Okayama, A., Goto, Y., Nonogi, H., Iwai, N. Circ. J. (2007) [Pubmed]
  8. Identification of an intronic TG repeat polymorphism in the human proteasome core particle PROS-27K gene. Sjakste, T., Lauberte, L., Collan, Y., Savontaus, M.L., Bajare, A., Scherrer, K., Sjakste, N. DNA Seq. (2002) [Pubmed]
  9. Bioactive abietane and seco-abietane diterpenoids from Salvia prionitis. Chen, X., Ding, J., Ye, Y.M., Zhang, J.S. J. Nat. Prod. (2002) [Pubmed]
  10. Exon/intron organisation of human proteasome PROS-27 K gene. Sjakste, T., Sjakste, N., Scherrer, K. DNA Seq. (2001) [Pubmed]
  11. Bacterial toxins modifying the actin cytoskeleton. Richard, J.F., Petit, L., Gibert, M., Marvaud, J.C., Bouchaud, C., Popoff, M.R. Int. Microbiol. (1999) [Pubmed]
  12. Changes in the subunit distribution of prosomes (MCP-proteasomes) during the differentiation of human leukemic cells. Baz, A., Henry, L., Caravano, R., Scherrer, K., Bureau, J.P. Int. J. Cancer (1997) [Pubmed]
  13. An autopsy case of bacterial septic shock 12 years following ABO-incompatible renal transplantation. Okamoto, M., Omori, Y., Ichida, M., Nobori, S., Higuchi, A., Kadotani, Y., Akioka, K., Itoh, K., Fushiki, S., Yoshimura, N. Clinical transplantation. (2004) [Pubmed]
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