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Gene Review

BCK1  -  Bck1p

Saccharomyces cerevisiae S288c

Synonyms: J0906, LAS3, SAP3, SLK1, SSP31, ...
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High impact information on BCK1


Biological context of BCK1


Anatomical context of BCK1

  • The upstream mitogen-activated protein kinase kinase kinase (MAPKKK, or MEKK), BCK1, is an essential component in this pathway for maintaining cell-wall integrity and preventing fungal cell lysis [8].

Associations of BCK1 with chemical compounds

  • The putative SSP31 protein also has a hybrid structure of serine/threonine and tyrosine kinases in the diagnostic subdomains for target specificity of protein kinases [9].

Regulatory relationships of BCK1

  • Pkc1 has been proposed to regulate a protein kinase cascade which includes the Bck1, Mkk1/Mkk2 and Mpk1 kinases [10].
  • The SSP31 gene of S. cerevisiae was isolated as a chromosomal DNA fragment suppressing the thermosensitive cell growth of the smp3 mutant when it was ligated into the low-copy vector, YCp50 [9].

Other interactions of BCK1

  • The MPK1 gene was isolated as a dosage-dependent suppressor of the cell lysis defect associated with deletion of the BCK1 gene [11].
  • This phenotypic defect is similar to that associated with deletion of the BCK1 gene, which is thought to function in the pathway mediated by PCK1 [12].
  • The different slk1 mutant defects are partially rescued by an extra copy of the SSD1/SRK1 gene [13].
  • The BCK1 gene product is not closely related to any known protein kinase, sharing only 45% amino acid identity with its closest known relative (the STE11-encoded protein kinase) through a region restricted to its putative C-terminal catalytic domain [7].
  • A new protein kinase, SSP31, modulating the SMP3 gene-product involved in plasmid maintenance in Saccharomyces cerevisiae [9].

Analytical, diagnostic and therapeutic context of BCK1


  1. Mammalian mitogen-activated protein kinase kinase kinase (MEKK) can function in a yeast mitogen-activated protein kinase pathway downstream of protein kinase C. Blumer, K.J., Johnson, G.L., Lange-Carter, C.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  2. Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Watanabe, Y., Takaesu, G., Hagiwara, M., Irie, K., Matsumoto, K. Mol. Cell. Biol. (1997) [Pubmed]
  3. Mkh1, a MEK kinase required for cell wall integrity and proper response to osmotic and temperature stress in Schizosaccharomyces pombe. Sengar, A.S., Markley, N.A., Marini, N.J., Young, D. Mol. Cell. Biol. (1997) [Pubmed]
  4. NHP6A and NHP6B, which encode HMG1-like proteins, are candidates for downstream components of the yeast SLT2 mitogen-activated protein kinase pathway. Costigan, C., Kolodrubetz, D., Snyder, M. Mol. Cell. Biol. (1994) [Pubmed]
  5. Sequence and function analysis of a 9.74 kb fragment of Saccharomyces cerevisiae chromosome X including the BCK1 gene. Miosga, T., Boles, E., Schaaff-Gerstenschläger, I., Schmitt, S., Zimmermann, F.K. Yeast (1994) [Pubmed]
  6. Arabidopsis thaliana cDNA isolated by functional complementation shows homology to serine/threonine protein kinases. Covic, L., Lew, R.R. Biochim. Biophys. Acta (1996) [Pubmed]
  7. Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog. Lee, K.S., Levin, D.E. Mol. Cell. Biol. (1992) [Pubmed]
  8. Pneumocystis carinii BCK1 functions in a mitogen-activated protein kinase cascade regulating fungal cell-wall assembly. Thomas, C.F., Vohra, P.K., Park, J.G., Puri, V., Limper, A.H., Kottom, T.J. FEBS Lett. (2003) [Pubmed]
  9. A new protein kinase, SSP31, modulating the SMP3 gene-product involved in plasmid maintenance in Saccharomyces cerevisiae. Irie, K., Araki, H., Oshima, Y. Gene (1991) [Pubmed]
  10. Functional analyses of mammalian protein kinase C isozymes in budding yeast and mammalian fibroblasts. Nomoto, S., Watanabe, Y., Ninomiya-Tsuji, J., Yang, L.X., Nagai, Y., Kiuchi, K., Hagiwara, M., Hidaka, H., Matsumoto, K., Irie, K. Genes Cells (1997) [Pubmed]
  11. A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C. Lee, K.S., Irie, K., Gotoh, Y., Watanabe, Y., Araki, H., Nishida, E., Matsumoto, K., Levin, D.E. Mol. Cell. Biol. (1993) [Pubmed]
  12. MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C. Irie, K., Takase, M., Lee, K.S., Levin, D.E., Araki, H., Matsumoto, K., Oshima, Y. Mol. Cell. Biol. (1993) [Pubmed]
  13. A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth. Costigan, C., Gehrung, S., Snyder, M. Mol. Cell. Biol. (1992) [Pubmed]
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