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Gene Review

ELF1  -  Elf1p

Saccharomyces cerevisiae S288c

Synonyms: Transcription elongation factor 1, YKL160W, YKL614
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Disease relevance of ELF1


High impact information on ELF1


Biological context of ELF1


Regulatory relationships of ELF1


Other interactions of ELF1


Analytical, diagnostic and therapeutic context of ELF1

  • Chromatin immunoprecipitation experiments show that Elf1 is cotranscriptionally recruited over actively transcribed regions and that this association is partially dependent on Spt4 and Spt6 [16].


  1. Characterization of the interactions among vaccinia virus transcription factors G2R, A18R, and H5R. Black, E.P., Moussatche, N., Condit, R.C. Virology (1998) [Pubmed]
  2. The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. Orphanides, G., Wu, W.H., Lane, W.S., Hampsey, M., Reinberg, D. Nature (1999) [Pubmed]
  3. Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae. Hartzog, G.A., Wada, T., Handa, H., Winston, F. Genes Dev. (1998) [Pubmed]
  4. DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs. Wada, T., Takagi, T., Yamaguchi, Y., Ferdous, A., Imai, T., Hirose, S., Sugimoto, S., Yano, K., Hartzog, G.A., Winston, F., Buratowski, S., Handa, H. Genes Dev. (1998) [Pubmed]
  5. Members of the SAGA and Mediator complexes are partners of the transcription elongation factor TFIIS. Wery, M., Shematorova, E., Van Driessche, B., Vandenhaute, J., Thuriaux, P., Van Mullem, V. EMBO J. (2004) [Pubmed]
  6. Cotranscriptional recruitment of the pseudouridylsynthetase Cbf5p and of the RNA binding protein Naf1p during H/ACA snoRNP assembly. Yang, P.K., Hoareau, C., Froment, C., Monsarrat, B., Henry, Y., Chanfreau, G. Mol. Cell. Biol. (2005) [Pubmed]
  7. Disruption studies of a Candida albicans gene, ELF1: a member of the ATP-binding cassette family. Sturtevant, J., Cihlar, R., Calderone, R. Microbiology (Reading, Engl.) (1998) [Pubmed]
  8. Identification and expression analysis of ABC protein-encoding genes in Toxoplasma gondii Toxoplasma gondii ATP-binding cassette superfamily. Sauvage, V., Millot, J.M., Aubert, D., Visneux, V., Marle-Plistat, M., Pinon, J.M., Villena, I. Mol. Biochem. Parasitol. (2006) [Pubmed]
  9. Elongin from Saccharomyces cerevisiae. Koth, C.M., Botuyan, M.V., Moreland, R.J., Jansma, D.B., Conaway, J.W., Conaway, R.C., Chazin, W.J., Friesen, J.D., Arrowsmith, C.H., Edwards, A.M. J. Biol. Chem. (2000) [Pubmed]
  10. RNA polymerase II subunit Rpb9 regulates transcription elongation in vivo. Hemming, S.A., Jansma, D.B., Macgregor, P.F., Goryachev, A., Friesen, J.D., Edwards, A.M. J. Biol. Chem. (2000) [Pubmed]
  11. Involvement of yeast carboxy-terminal domain kinase I (CTDK-I) in transcription elongation in vivo. Jona, G., Wittschieben, B.O., Svejstrup, J.Q., Gileadi, O. Gene (2001) [Pubmed]
  12. Yeast RNA polymerase II subunit RPB9. Mapping of domains required for transcription elongation. Hemming, S.A., Edwards, A.M. J. Biol. Chem. (2000) [Pubmed]
  13. Arginine methylation of yeast mRNA-binding protein Npl3 directly affects its function, nuclear export, and intranuclear protein interactions. McBride, A.E., Cook, J.T., Stemmler, E.A., Rutledge, K.L., McGrath, K.A., Rubens, J.A. J. Biol. Chem. (2005) [Pubmed]
  14. Synthetic lethal interactions suggest a role for the Saccharomyces cerevisiae Rtf1 protein in transcription elongation. Costa, P.J., Arndt, K.M. Genetics (2000) [Pubmed]
  15. A transformation system for the nonuniversal CUG(Ser) codon usage species Candida rugosa. Tang, S.J., Sun, K.H., Sun, G.H., Chang, T.Y., Wu, W.L., Lee, G.C. J. Microbiol. Methods (2003) [Pubmed]
  16. Identification and characterization of Elf1, a conserved transcription elongation factor in Saccharomyces cerevisiae. Prather, D., Krogan, N.J., Emili, A., Greenblatt, J.F., Winston, F. Mol. Cell. Biol. (2005) [Pubmed]
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