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Gene Review

SSRP1  -  structure specific recognition protein 1

Homo sapiens

Synonyms: Chromatin-specific transcription elongation factor 80 kDa subunit, FACT, FACT 80 kDa subunit, FACT complex subunit SSRP1, FACT80, ...
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Disease relevance of SSRP1


Psychiatry related information on SSRP1


High impact information on SSRP1


Biological context of SSRP1


Anatomical context of SSRP1

  • Expression analysis in a variety of tissues and cisplatin-resistant cell lines and the inability of cisplatin to induce the message in HeLa cells argue against a direct link between SSRP1 mRNA levels and the response of cells to the drug [12].
  • Moreover, we show that SSRP1/PREIIBF lacks a classical activation domain but that binding by this protein to PRE II is required for activation of a minimal promoter in stable erythroid cell lines [13].
  • Collectively, these findings indicate a role for SSRP1 in the UV response of eukaryotic cells [17].
  • To determine whether HMG-1 box protein T160 plays a role in virus replication, we employed an antisense strategy to inhibit its expression in NIH 3T3 cells [18].
  • Tourniquet-induced restriction of the quadriceps muscle mechanism. Fact or fiction [19]?

Associations of SSRP1 with chemical compounds


Other interactions of SSRP1

  • These results reveal an important role for SSRP1 as a coregulator of SRF-dependent transcription in mammalian cells [23].
  • SSRP1/PREIIBF may serve an architectural function by helping to coordinate the assembly of a multiprotein complex required for stage-specific regulation of the human epsilon-globin gene [13].
  • This was confirmed by treatment of chromatin with micrococcal nuclease, demonstrating that the HMGA, HMGB2/3, and SSRP1 proteins are enriched in the highly nuclease-sensitive fraction of chromatin, which is likely to be transcriptionally competent [20].

Analytical, diagnostic and therapeutic context of SSRP1


  1. Prevalence of autoantibodies against structure specific recognition protein 1 in systemic lupus erythematosus. Fineschi, S., Borghi, M.O., Riboldi, P., Gariglio, M., Buzio, C., Landolfo, S., Cebecauer, L., Tuchynova, A., Rovensky, J., Meroni, P.L. Lupus (2004) [Pubmed]
  2. The pain of pulmonary hypertension. Fact or fancy? Zimmerman, D., Parker, B.M. JAMA (1981) [Pubmed]
  3. "Food allergy": Fact or Fiction? Finn, R., Cohen, H.N. Lancet (1978) [Pubmed]
  4. Trypanosomiasis and Tsetse Control with Insecticidal Pour-ons- Fact and Fiction? Baylis, M., Stevenson, P. Parasitol. Today (Regul. Ed.) (1998) [Pubmed]
  5. Simple carbohydrates and obesity: Fact, Fiction and Future. Saris, W.H., Foster, G.D. International journal of obesity (2005) (2006) [Pubmed]
  6. Patient and Family Fact Sheet. Tourette syndrome. Whitney, C.M. The neurologist. (2005) [Pubmed]
  7. Featured CME topic: dementia. Fact sheets. Hamdy, R.C. South. Med. J. (2001) [Pubmed]
  8. Psychometric evaluation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (Fact/GOG-Ntx) questionnaire for patients receiving systemic chemotherapy. Calhoun, E.A., Welshman, E.E., Chang, C.H., Lurain, J.R., Fishman, D.A., Hunt, T.L., Cella, D. Int. J. Gynecol. Cancer (2003) [Pubmed]
  9. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Keller, D.M., Zeng, X., Wang, Y., Zhang, Q.H., Kapoor, M., Shu, H., Goodman, R., Lozano, G., Zhao, Y., Lu, H. Mol. Cell (2001) [Pubmed]
  10. The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases. Brown, N.R., Noble, M.E., Endicott, J.A., Johnson, L.N. Nat. Cell Biol. (1999) [Pubmed]
  11. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. Gu, Y., Rosenblatt, J., Morgan, D.O. EMBO J. (1992) [Pubmed]
  12. Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. Bruhn, S.L., Pil, P.M., Essigmann, J.M., Housman, D.E., Lippard, S.J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  13. The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene. Dyer, M.A., Hayes, P.J., Baron, M.H. Mol. Cell. Biol. (1998) [Pubmed]
  14. CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity. Li, Y., Keller, D.M., Scott, J.D., Lu, H. J. Biol. Chem. (2005) [Pubmed]
  15. CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin. Kelley, D.E., Stokes, D.G., Perry, R.P. Chromosoma (1999) [Pubmed]
  16. Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin. Yarnell, A.T., Oh, S., Reinberg, D., Lippard, S.J. J. Biol. Chem. (2001) [Pubmed]
  17. Protein kinase CK2 phosphorylates the high mobility group domain protein SSRP1, inducing the recognition of UV-damaged DNA. Krohn, N.M., Stemmer, C., Fojan, P., Grimm, R., Grasser, K.D. J. Biol. Chem. (2003) [Pubmed]
  18. Suppression of high mobility group protein T160 expression impairs mouse cytomegalovirus replication. Gariglio, M., Foresta, P., Sacchi, C., Lembo, M., Hertel, L., Landolfo, S. J. Gen. Virol. (1997) [Pubmed]
  19. Tourniquet-induced restriction of the quadriceps muscle mechanism. Fact or fiction? Herald, J., Cooper, L., Machart, F. The Journal of bone and joint surgery. British volume. (2002) [Pubmed]
  20. Differential chromatin association and nucleosome binding of the maize HMGA, HMGB, and SSRP1 proteins. Lichota, J., Grasser, K.D. Biochemistry (2001) [Pubmed]
  21. Viscosupplementation therapy with intra-articular hyaluronic acid. Fact or fantasy? Simon, L.S. Rheum. Dis. Clin. North Am. (1999) [Pubmed]
  22. Careers "Fact Sheets" for clinical engineering & biomedical technology. Pacela, A.F. Journal of clinical engineering. (1991) [Pubmed]
  23. Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1. Spencer, J.A., Baron, M.H., Olson, E.N. J. Biol. Chem. (1999) [Pubmed]
  24. The 30th Sir Frederick Bartlett lecture. Fact, artefact, and myth about blindsight. Cowey, A. The Quarterly journal of experimental psychology. A, Human experimental psychology. (2004) [Pubmed]
  25. Functional neck dissection: Fact and fiction. Ferlito, A., Gavilàn, J., Buckley, J.G., Shaha, A.R., Miodoński, A.J., Rinaldo, A. Head & neck. (2001) [Pubmed]
  26. Human cloning. Fact or fiction. Abushama, M.D., Ahmed, B.I. Saudi medical journal. (2003) [Pubmed]
  27. Orthodontics. Part 7: Fact and fantasy in orthodontics. Williams, P., Roberts-Harry, D., Sandy, J. British dental journal. (2004) [Pubmed]
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