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Gene Review

MSN1  -  Msn1p

Saccharomyces cerevisiae S288c

Synonyms: FUP1, HRB382, MSS10, Multicopy suppressor of SNF1 protein 1, PHD2, ...
 
 
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High impact information on MSN1

  • The deletion of MSS10 resulted in extremely reduced amounts of pseudohyphal differentiation and invasive growth, whereas the deletion of MUC1 abolished pseudohyphal differentiation and invasive growth completely [1].
  • Osmotic stress-induced gene expression in Saccharomyces cerevisiae requires Msn1p and the novel nuclear factor Hot1p [2].
  • Strains lacking the MAPK Hog1p, the upstream component Ssk1p or the HOG-dependent nuclear factor Msn1p, showed a reduction in the mRNA accumulation of MG-responsive genes after MG addition [3].
  • Both MSN1 and MSS11 are involved in the co-regulation of starch degradation and invasive growth [4].
  • In addition, our results suggest that the activity of Msn1p is independent of the invasive growth MAP kinase cascade, but the Mss11p is required for the activation of pseudohyphal and invasive growth by Ste12p [4].
 

Biological context of MSN1

 

Anatomical context of MSN1

 

Associations of MSN1 with chemical compounds

  • Expression of yeast transcriptional activator MSN1 promotes accumulation of chromium and sulfur by enhancing sulfate transporter level in plants [9].
  • Disruption of the FUP1 locus reduces wild-type iron uptake rates by 2-fold in cells grown on raffinose medium but has no effect on glucose-grown cells [10].
 

Other interactions of MSN1

  • We show that MUC1 mediates the effect of Msn1p and Mss11p on invasive growth [4].
  • We found that MSN1, which encodes a transcriptional activator, and NHP6A, which encodes an HMG-like protein, are able to suppress defective Swi6 function [11].
 

Analytical, diagnostic and therapeutic context of MSN1

  • Using IPCR (inverse PCR), we found that the mini-Tn had been inserted at nt 741 of the transcriptional activator, MSN1 [6].

References

  1. Muc1, a mucin-like protein that is regulated by Mss10, is critical for pseudohyphal differentiation in yeast. Lambrechts, M.G., Bauer, F.F., Marmur, J., Pretorius, I.S. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Osmotic stress-induced gene expression in Saccharomyces cerevisiae requires Msn1p and the novel nuclear factor Hot1p. Rep, M., Reiser, V., Gartner, U., Thevelein, J.M., Hohmann, S., Ammerer, G., Ruis, H. Mol. Cell. Biol. (1999) [Pubmed]
  3. The HOG MAP kinase pathway is required for the induction of methylglyoxal-responsive genes and determines methylglyoxal resistance in Saccharomyces cerevisiae. Aguilera, J., Rodríguez-Vargas, S., Prieto, J.A. Mol. Microbiol. (2005) [Pubmed]
  4. Msn1p/Mss10p, Mss11p and Muc1p/Flo11p are part of a signal transduction pathway downstream of Mep2p regulating invasive growth and pseudohyphal differentiation in Saccharomyces cerevisiae. Gagiano, M., van Dyk, D., Bauer, F.F., Lambrechts, M.G., Pretorius, I.S. Mol. Microbiol. (1999) [Pubmed]
  5. Increased dosage of the MSN1 gene restores invertase expression in yeast mutants defective in the SNF1 protein kinase. Estruch, F., Carlson, M. Nucleic Acids Res. (1990) [Pubmed]
  6. The putative transcriptional activator MSN1 promotes chromium accumulation in Saccharomyces cerevisiae. Chang, K.S., Won, J.I., Lee, M.R., Lee, C.E., Kim, K.H., Park, K.Y., Kim, S.K., Lee, J.S., Hwang, S. Mol. Cells (2003) [Pubmed]
  7. A multicopy suppressor gene, MSS10, restores STA2 expression in Saccharomyces cerevisiae strains containing the STA10 repressor gene. Lambrechts, M.G., Sollitti, P., Marmur, J., Pretorius, I.S. Curr. Genet. (1996) [Pubmed]
  8. Variations in mRNA transcript levels of cell wall-associated genes of Saccharomyces cerevisiae following spheroplasting. Braley, R., Chaffin, W.L. FEMS Microbiol. Lett. (1999) [Pubmed]
  9. Expression of yeast transcriptional activator MSN1 promotes accumulation of chromium and sulfur by enhancing sulfate transporter level in plants. Kim, Y.J., Kim, J.H., Lee, C.E., Mok, Y.G., Choi, J.S., Shin, H.S., Hwang, S. FEBS Lett. (2006) [Pubmed]
  10. Increased dosage of a transcriptional activator gene enhances iron-limited growth of Saccharomyces cerevisiae. Eide, D., Guarente, L. J. Gen. Microbiol. (1992) [Pubmed]
  11. The MSN1 and NHP6A genes suppress SWI6 defects in Saccharomyces cerevisiae. Sidorova, J., Breeden, L. Genetics (1999) [Pubmed]
 
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