Gene Review:
SEC63 - Sec63p
Saccharomyces cerevisiae S288c
Synonyms:
NPL1, PTL1, Protein NPL1, Protein translocation protein SEC63, Sec62/63 complex 73 kDa subunit, ...
- A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein. Sadler, I., Chiang, A., Kurihara, T., Rothblatt, J., Way, J., Silver, P. J. Cell Biol. (1989)
- BiP acts as a molecular ratchet during posttranslational transport of prepro-alpha factor across the ER membrane. Matlack, K.E., Misselwitz, B., Plath, K., Rapoport, T.A. Cell (1999)
- Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex. Deshaies, R.J., Sanders, S.L., Feldheim, D.A., Schekman, R. Nature (1991)
- A novel type of co-chaperone mediates transmembrane recruitment of DnaK-like chaperones to ribosomes. Dudek, J., Volkmer, J., Bies, C., Guth, S., Müller, A., Lerner, M., Feick, P., Schäfer, K.H., Morgenstern, E., Hennessy, F., Blatch, G.L., Janoscheck, K., Heim, N., Scholtes, P., Frien, M., Nastainczyk, W., Zimmermann, R. EMBO J. (2002)
- Sec63p and Kar2p are required for the translocation of SRP-dependent precursors into the yeast endoplasmic reticulum in vivo. Young, B.P., Craven, R.A., Reid, P.J., Willer, M., Stirling, C.J. EMBO J. (2001)
- ER membrane protein complex required for nuclear fusion. Ng, D.T., Walter, P. J. Cell Biol. (1996)
- The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum. Esnault, Y., Blondel, M.O., Deshaies, R.J., Scheckman, R., Képès, F. EMBO J. (1993)
- Suppression of a sec63 mutation identifies a novel component of the yeast endoplasmic reticulum translocation apparatus. Kurihara, T., Silver, P. Mol. Biol. Cell (1993)
- Interaction between BiP and Sec63p is required for the completion of protein translocation into the ER of Saccharomyces cerevisiae. Lyman, S.K., Schekman, R. J. Cell Biol. (1995)
- Protein kinase CK2 phosphorylates Sec63p to stimulate the assembly of the endoplasmic reticulum protein translocation apparatus. Wang, X., Johnsson, N. J. Cell. Sci. (2005)
- Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast. Rothblatt, J.A., Deshaies, R.J., Sanders, S.L., Daum, G., Schekman, R. J. Cell Biol. (1989)
- BiP and Sec63p are required for both co- and posttranslational protein translocation into the yeast endoplasmic reticulum. Brodsky, J.L., Goeckeler, J., Schekman, R. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Sordarin Derivatives Induce a Novel Conformation of the Yeast Ribosome Translocation Factor eEF2. S??e, R., Mosley, R.T., Justice, M., Nielsen-Kahn, J., Shastry, M., Merrill, A.R., Andersen, G.R. J. Biol. Chem. (2007)
- Topology and functional domains of Sec63p, an endoplasmic reticulum membrane protein required for secretory protein translocation. Feldheim, D., Rothblatt, J., Schekman, R. Mol. Cell. Biol. (1992)
- Sls1p stimulates Sec63p-mediated activation of Kar2p in a conformation-dependent manner in the yeast endoplasmic reticulum. Kabani, M., Beckerich, J.M., Gaillardin, C. Mol. Cell. Biol. (2000)
- Identification of novel protein-protein interactions at the cytosolic surface of the Sec63 complex in the yeast ER membrane. Willer, M., Jermy, A.J., Young, B.P., Stirling, C.J. Yeast (2003)
- Polypeptide translocation machinery of the yeast endoplasmic reticulum. Lyman, S.K., Schekman, R. Experientia (1996)
- The lumenal domain of Sec63p stimulates the ATPase activity of BiP and mediates BiP recruitment to the translocon in Saccharomyces cerevisiae. Corsi, A.K., Schekman, R. J. Cell Biol. (1997)
- A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome. Brodsky, J.L., Schekman, R. J. Cell Biol. (1993)
- A yeast DnaJ homologue, Scj1p, can function in the endoplasmic reticulum with BiP/Kar2p via a conserved domain that specifies interactions with Hsp70s. Schlenstedt, G., Harris, S., Risse, B., Lill, R., Silver, P.A. J. Cell Biol. (1995)