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Gene Review

BLZF1  -  basic leucine zipper nuclear factor 1

Homo sapiens

Synonyms: Basic leucine zipper nuclear factor 1, GOLGIN-45, Golgin-45, JEM-1, JEM-1s, ...
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Disease relevance of BLZF1

  • The JEM-1 gene, recently identified in acute promyelocytic leukemia (APL) cells, codes for a novel nuclear factor (Duprez et al Oncogene 1997; 14: 1563-1570) [1].
  • Cell lines derived from monocytic and erythroid leukemias, expressed low and high amounts of JEM-1 mRNA, respectively [1].
  • Eight spirochetal isolates (JEM1 to JEM8) were obtained from cutaneous lesions of patients with Lyme disease in Hokkaido, Japan, and were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, reactivities with monoclonal and polyclonal antibodies, and Southern blot hybridization [2].

High impact information on BLZF1


Biological context of BLZF1


Anatomical context of BLZF1

  • JEM-1 is kept silent in the APL cell line NB4, but up-regulated (3 kb transcript) during cell maturation [1].
  • APL patients showed a low, yet variable, level of JEM-1 mRNA in bone marrow [1].
  • In this issue, Short et al. report the discovery of a protein named Golgin-45 that is located on the surface of the middle (or medial) cisternae of the Golgi complex [4].

Associations of BLZF1 with chemical compounds

  • This work identifies JEM-1 as a novel ubiquitous gene whose expression is low in APL cells, but can be restored by RA treatment, concomitant with cell maturation [1].
  • Here, we show that retinoic acid (RA)-induced JEM-1 expression is biphasic (peaks at 6 h and 48 h) and associated with the later stages of maturation [1].

Analytical, diagnostic and therapeutic context of BLZF1

  • RA treatment induced an increase in the level of JEM-1 mRNA, as detected by a semi-quantitative PCR [1].


  1. Expression patterns of the JEM-1 gene in normal and tumor cells: ubiquity contrasting with a faint, but retinoid-induced, mRNA expression in promyelocytic NB4 cells. Tong, J.H., Fant, X., Duprez, E., Benoit, G., Uphoff, C.C., Drexler, H.G., Pla, J.C., Lofvenberg, E., Lanotte, M. Leukemia (1998) [Pubmed]
  2. Evaluation of genetic divergence of borrelial isolates from Lyme disease patients in Hokkaido, Japan, by rRNA gene probes. Fukunaga, M., Sohnaka, M., Nakao, M., Miyamoto, K. J. Clin. Microbiol. (1993) [Pubmed]
  3. A GRASP55-rab2 effector complex linking Golgi structure to membrane traffic. Short, B., Preisinger, C., Körner, R., Kopajtich, R., Byron, O., Barr, F.A. J. Cell Biol. (2001) [Pubmed]
  4. Constructing a Golgi complex. Pfeffer, S.R. J. Cell Biol. (2001) [Pubmed]
  5. JEM-1, a novel gene encoding a leucine-zipper nuclear factor upregulated during retinoid-induced maturation of NB4 promyelocytic leukaemia. Duprez, E., Tong, J.H., Dérré, J., Chen, S.J., Berger, R., Chen, Z., Lanotte, M. Oncogene (1997) [Pubmed]
  6. JEM-1, a novel nuclear co-factor: localisation and functional interaction with AP-1. Tong, J.H., Duprez, E., Lanotte, M. Leukemia (1999) [Pubmed]
  7. Genomic organization of the JEM-1 (BLZF1) gene on human chromosome 1q24: molecular cloning and analysis of its promoter region. Tong, J.H., Fant, X., Benoit, G., Chen, S.J., Chen, Z., Lanotte, M. Genomics (2000) [Pubmed]
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