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Gene Review

GLO1  -  lactoylglutathione lyase GLO1

Saccharomyces cerevisiae S288c

Synonyms: Aldoketomutase, Glx I, Glyoxalase I, Ketone-aldehyde mutase, Lactoylglutathione lyase, ...
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High impact information on GLO1


Biological context of GLO1

  • The GLO1 gene contained an open reading frame with 326 amino acids, and the molecular weight of the gene product (Glo1p) deduced from the DNA sequence was calculated to be 37,207.06 [2].
  • Glyoxalase-I activity and cell cycle regulation in yeast [3].
  • Results demonstrate that although glyoxalase-I activity is a good indicator of cell growth status, it is not involved in cell cycle regulation of this eukaryotic organism [3].
  • In one of these mutants, which showed a specific morphological phenotype, the tagged gene, glo1 , was found to encode a product that is highly homologous to a glyoxal oxidase gene from the wood-rot fungus Phanerochaete chrysosporium [4].

Associations of GLO1 with chemical compounds


Other interactions of GLO1


  1. Expression of the glyoxalase I gene of Saccharomyces cerevisiae is regulated by high osmolarity glycerol mitogen-activated protein kinase pathway in osmotic stress response. Inoue, Y., Tsujimoto, Y., Kimura, A. J. Biol. Chem. (1998) [Pubmed]
  2. Identification of the structural gene for glyoxalase I from Saccharomyces cerevisiae. Inoue, Y., Kimura, A. J. Biol. Chem. (1996) [Pubmed]
  3. Glyoxalase-I activity and cell cycle regulation in yeast. Dudani, A.K., Srivastava, L.K., Prasad, R. Biochem. Biophys. Res. Commun. (1984) [Pubmed]
  4. A H2O2-producing glyoxal oxidase is required for filamentous growth and pathogenicity in Ustilago maydis. Leuthner, B., Aichinger, C., Oehmen, E., Koopmann, E., Müller, O., Müller, P., Kahmann, R., Bölker, M., Schreier, P.H. Mol. Genet. Genomics (2005) [Pubmed]
  5. Partial transition-state inhibitors of glyoxalase I from human erythrocytes, yeast and rat liver. Douglas, K.T., Gohel, D.I., Nadvi, I.N., Quilter, A.J., Seddon, A.P. Biochim. Biophys. Acta (1985) [Pubmed]
  6. The HOG MAP kinase pathway is required for the induction of methylglyoxal-responsive genes and determines methylglyoxal resistance in Saccharomyces cerevisiae. Aguilera, J., Rodríguez-Vargas, S., Prieto, J.A. Mol. Microbiol. (2005) [Pubmed]
  7. Nitrosative stress on yeast: inhibition of glyoxalase-I and glyceraldehyde-3-phosphate dehydrogenase in the presence of GSNO. Sahoo, R., Sengupta, R., Ghosh, S. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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