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Gene Review

FOL1  -  trifunctional dihydropteroate...

Saccharomyces cerevisiae S288c

Synonyms: Folic acid synthesis protein FOL1, N0848, YNL256W
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Disease relevance of FOL1


High impact information on FOL1


Biological context of FOL1


Associations of FOL1 with chemical compounds


Analytical, diagnostic and therapeutic context of FOL1


  1. Analysis of Pneumocystis jirovecii DHPS alleles implicated in sulfamethoxazole resistance using an Escherichia coli model system. Iliades, P., Meshnick, S.R., Macreadie, I.G. Microb. Drug Resist. (2005) [Pubmed]
  2. Characterization of the Saccharomyces cerevisiae Fol1 protein: starvation for C1 carrier induces pseudohyphal growth. Güldener, U., Koehler, G.J., Haussmann, C., Bacher, A., Kricke, J., Becher, D., Hegemann, J.H. Mol. Biol. Cell (2004) [Pubmed]
  3. Control of expression of one-carbon metabolism genes of Saccharomyces cerevisiae is mediated by a tetrahydrofolate-responsive protein binding to a glycine regulatory region including a core 5'-CTTCTT-3' motif. Hong, S.P., Piper, M.D., Sinclair, D.A., Dawes, I.W. J. Biol. Chem. (1999) [Pubmed]
  4. Promoter strength of folic acid synthesis genes affects sulfa drug resistance in Saccharomyces cerevisiae. Iliades, P., Berglez, J., Meshnick, S., Macreadie, I. Microb. Drug Resist. (2003) [Pubmed]
  5. Folic acid utilisation related to sulfa drug resistance in Saccharomyces cerevisiae. Bayly, A.M., Berglez, J.M., Patel, O., Castelli, L.A., Hankins, E.G., Coloe, P., Hopkins Sibley, C., Macreadie, I.G. FEMS Microbiol. Lett. (2001) [Pubmed]
  6. Site-directed mutagenesis of the Saccharomyces cerevisiae dihydropteroate synthase FOL1 gene to study Pneumocystis jirovecii mutations in the orthologue gene FAS. Meneau, I., Sanglard, D., Bille, J., Hauser, P.M. J. Eukaryot. Microbiol. (2003) [Pubmed]
  7. Pneumocystis jiroveci dihydropteroate synthase polymorphisms confer resistance to sulfadoxine and sulfanilamide in Saccharomyces cerevisiae. Meneau, I., Sanglard, D., Bille, J., Hauser, P.M. Antimicrob. Agents Chemother. (2004) [Pubmed]
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