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Gene Review

KRE6  -  beta-glucan synthesis-associated protein KRE6

Saccharomyces cerevisiae S288c

Synonyms: Beta-glucan synthesis-associated protein KRE6, CWH48, Killer toxin-resistance protein 6, YPR159W
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High impact information on KRE6

  • KRE6 and SKN1 are predicted to encode homologous proteins that participate in assembly of the cell wall polymer (1-->6)-beta-glucan [1].
  • Kre6p when even mildly overproduced, can suppress this pkc1 lysis defect [1].
  • Mutations in two other loci, KRE5 and KRE6 also lead to a defect in cell wall (1----6)-beta-glucan production and appear to be epistatic to KRE1 [2].
  • The KRE6 gene product is required for synthesis of the major beta-glucans of the yeast cell wall, as mutations in this gene confer reduced levels of both the (1----6)- and (1----3)-beta-D-glucan polymers [3].
  • Yeast beta-glucan synthesis: KRE6 encodes a predicted type II membrane protein required for glucan synthesis in vivo and for glucan synthase activity in vitro [3].

Biological context of KRE6


Anatomical context of KRE6

  • It has been postulated that the synthesis of beta1,6-glucan begins in the endoplasmic reticulum with the formation of protein-bound primer structures and that these primer structures are extended in the Golgi complex by two putative glucosyltransferases that are functionally redundant, Kre6 and Skn1 [5].

Associations of KRE6 with chemical compounds

  • Synthetic defects for growth are also observed with mutation in KRE6, a gene coding for a glucan synthase, required for cell wall construction [6].

Regulatory relationships of KRE6

  • The results of Northern blot analysis revealed that C. albicans KRE6 was expressed at a higher level than SKN1 in the yeast phase, while SKN1 expression was strongly induced upon induction of hyphal formation [7].
  • When KRE6 transcription was suppressed by using the HEX1 promoter, C. albicans cells exhibited the partial defect in cell separation and increased susceptibility to Calcofluor White [7].

Other interactions of KRE6

  • CWH41 also displays strong genetic interactions with KRE1 and KRE6, two genes known to be involved in the beta 1,6-glucan biosynthetic pathway [8].
  • Successful incorporation of HA-tagged Sed1p into the cell wall involves KRE6 [9].
  • The indispensability of BIG1 and KRE6 for the viability of gas1Delta cells confirmed the important role of beta-1,6-glucan in cells that are defective in the processing of beta-1,3-glucan [10].
  • KRE6, encoding a glucanase-like protein, was identified as a multicopy suppressor of a temperature-sensitive kre5 allele, suggesting that these proteins may participate in a common beta-1,6-biosynthetic pathway [11].
  • Kre6p showed extensive co-localization with Och1p-containing cis-Golgi vesicles [12].


  1. Characterization of the yeast (1-->6)-beta-glucan biosynthetic components, Kre6p and Skn1p, and genetic interactions between the PKC1 pathway and extracellular matrix assembly. Roemer, T., Paravicini, G., Payton, M.A., Bussey, H. J. Cell Biol. (1994) [Pubmed]
  2. Yeast KRE genes provide evidence for a pathway of cell wall beta-glucan assembly. Boone, C., Sommer, S.S., Hensel, A., Bussey, H. J. Cell Biol. (1990) [Pubmed]
  3. Yeast beta-glucan synthesis: KRE6 encodes a predicted type II membrane protein required for glucan synthesis in vivo and for glucan synthase activity in vitro. Roemer, T., Bussey, H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. DNA sequence analysis of a 10.4 kbp region on the right arm of yeast chromosome XVI positions GPH1 and SGV1 adjacent to KRE6, and identifies two novel tRNA genes. Roemer, T., Fortin, N., Bussey, H. Yeast (1994) [Pubmed]
  5. Localization of synthesis of beta1,6-glucan in Saccharomyces cerevisiae. Montijn, R.C., Vink, E., Müller, W.H., Verkleij, A.J., Van Den Ende, H., Henrissat, B., Klis, F.M. J. Bacteriol. (1999) [Pubmed]
  6. The yeast Rvs161 and Rvs167 proteins are involved in secretory vesicles targeting the plasma membrane and in cell integrity. Breton, A.M., Schaeffer, J., Aigle, M. Yeast (2001) [Pubmed]
  7. Isolation of the Candida albicans homologs of Saccharomyces cerevisiae KRE6 and SKN1: expression and physiological function. Mio, T., Yamada-Okabe, T., Yabe, T., Nakajima, T., Arisawa, M., Yamada-Okabe, H. J. Bacteriol. (1997) [Pubmed]
  8. CWH41 encodes a novel endoplasmic reticulum membrane N-glycoprotein involved in beta 1,6-glucan assembly. Jiang, B., Sheraton, J., Ram, A.F., Dijkgraaf, G.J., Klis, F.M., Bussey, H. J. Bacteriol. (1996) [Pubmed]
  9. Incorporation of Sed1p into the cell wall of Saccharomyces cerevisiae involves KRE6. Bowen, S., Wheals, A.E. FEMS Yeast Res. (2004) [Pubmed]
  10. Mutations that are synthetically lethal with a gas1Delta allele cause defects in the cell wall of Saccharomyces cerevisiae. Tomishige, N., Noda, Y., Adachi, H., Shimoi, H., Takatsuki, A., Yoda, K. Mol. Genet. Genomics (2003) [Pubmed]
  11. Functional, comparative and cell biological analysis of Saccharomyces cerevisiae Kre5p. Levinson, J.N., Shahinian, S., Sdicu, A.M., Tessier, D.C., Bussey, H. Yeast (2002) [Pubmed]
  12. Actin patch assembly proteins Las17p and Sla1p restrict cell wall growth to daughter cells and interact with cis-Golgi protein Kre6p. Li, H., Pagé, N., Bussey, H. Yeast (2002) [Pubmed]
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