Disease relevance of RRP1

• Novel nuclear export signal-interacting protein, NESI, critical for the assembly of hepatitis delta virus [1].
• Novel nuclear phosphoprotein pp32 is highly expressed in intermediate- and high-grade prostate cancer [2].
• Novel nuclear antigens recognized by human sera in lymphocytes latently infected by Epstein-Barr virus [3].
• We conclude that these nine genes, especially NNP-1, probably contribute either directly or indirectly to keloid formation [4].

High impact information on RRP1

• Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma [5].
• In early telophase, fibrillarin is concentrated simultaneously in prenucleolar bodies (PNBs) and NORs, whereas PNB-containing Nop52 forms later [6].
• A Novel Nuclear Interactor of ARF and MDM2 (NIAM) That Maintains Chromosomal Stability [7].
• In nucleoli, Nop52 is excluded from the ribosomal RNA transcription sites, accumulates in the granular external domain and mainly colocalizes with nucleolar proteins involved in the late processing step such as hPop1 and protein B23 [8].
• Control of Allograft Rejection by Applying a Novel Nuclear Factor-kappaB Inhibitor, Dehydroxymethylepoxyquinomicin [9].

Biological context of RRP1

• As indicated by sequence analysis, these antigens were generated by alternative splicing and/or alternative promoter usage or allelic polymorphism. mRNA expression analyses revealed different tissue restrictions of novel compared to known HuD and NNP-1 transcripts in normal and malignant tissues [10].
• To follow in living cells two permanently transfected green fluorescence protein-tagged nucleolar proteins, fibrillarin and Nop52, from metaphase to G1, 4-D time-lapse microscopy was used [6].
• Novel nuclear ribonucleoprotein structural components in the dormouse adrenal cortex during hibernation [11].
• Novel nuclear localization signal between the two DNA-binding zinc fingers in the human vitamin D receptor [12].
• Two Novel Nuclear Genes, OsSIG5 and OsSIG6, Encoding Potential Plastid Sigma Factors of RNA Polymerase in Rice: Tissue-Specific and Light-Responsive Gene Expression [13].

Analytical, diagnostic and therapeutic context of RRP1

• Of the nine, the NNP-1 gene was confirmed by topological information using the in situ hybridization technique [4].

References