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Gene Review

MPDZ  -  multiple PDZ domain protein

Homo sapiens

Synonyms: HYC2, MUPP1, Multi-PDZ domain protein 1, Multiple PDZ domain protein
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Disease relevance of MPDZ


High impact information on MPDZ

  • Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2 [3].
  • The highest MUPP1 mRNA levels were found in all cerebral cortical layers, the hippocampus, the granular layer of the dentate gyrus, as well as the choroid plexus, where 5-HT(2C) receptors are highly enriched [1].
  • Co-immunoprecipitations of MUPP1 and 5-HT(2C) receptors from transfected COS-7 cells and from rat choroid plexus verified this interaction in vivo [1].
  • These results suggest that in the context of HPV-induced transformation Dlg, MAGI-1 and MUPP1 can function as tumour suppressors [4].
  • Q-PCR revealed a reduction in the levels of ZO-1 and MUPP-1 in patients with disease recurrence [2].

Biological context of MPDZ

  • Cloning and characterization of MUPP1, a novel PDZ domain protein [5].
  • The MUPP1 gene is localized on human chromosome 9p24-p22 [5].
  • The protein, named MUPP1 (multi-PDZ-domain protein), contains thirteen PDZ domains and no obvious catalytic domain; it is related to hINADL and a putative C. elegans polypeptide referred to as C52A11.4 containing six or ten PDZ domains, respectively [5].

Anatomical context of MPDZ


Associations of MPDZ with chemical compounds


  1. Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. Becamel, C., Figge, A., Poliak, S., Dumuis, A., Peles, E., Bockaert, J., Lubbert, H., Ullmer, C. J. Biol. Chem. (2001) [Pubmed]
  2. Loss of tight junction plaque molecules in breast cancer tissues is associated with a poor prognosis in patients with breast cancer. Martin, T.A., Watkins, G., Mansel, R.E., Jiang, W.G. Eur. J. Cancer (2004) [Pubmed]
  3. Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2. Wu, X., Hepner, K., Castelino-Prabhu, S., Do, D., Kaye, M.B., Yuan, X.J., Wood, J., Ross, C., Sawyers, C.L., Whang, Y.E. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. HPV E6 specifically targets different cellular pools of its PDZ domain-containing tumour suppressor substrates for proteasome-mediated degradation. Massimi, P., Gammoh, N., Thomas, M., Banks, L. Oncogene (2004) [Pubmed]
  5. Cloning and characterization of MUPP1, a novel PDZ domain protein. Ullmer, C., Schmuck, K., Figge, A., Lübbert, H. FEBS Lett. (1998) [Pubmed]
  6. The urethra (UPP, MUPP, instability, LPP). Khullar, V., Cardozo, L. Eur. Urol. (1998) [Pubmed]
  7. Serotonin 5-HT2 receptors and alcohol: reward, withdrawal and discrimination. Buck, K.J., Reilly, M.T., Rogers, L.M., Szeliga, K., Grant, K., Brodie, M.S. Alcohol. Clin. Exp. Res. (2004) [Pubmed]
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