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Gene Review

TJP1  -  tight junction protein 1

Homo sapiens

Synonyms: DKFZp686M05161, MGC133289, Tight junction protein 1, Tight junction protein ZO-1, ZO-1, ...
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Disease relevance of TJP1


Psychiatry related information on TJP1


High impact information on TJP1


Chemical compound and disease context of TJP1


Biological context of TJP1


Anatomical context of TJP1


Associations of TJP1 with chemical compounds


Physical interactions of TJP1


Co-localisations of TJP1

  • Canonical transient receptor potential channel 4 (TRPC4) co-localizes with the scaffolding protein ZO-1 in human fetal astrocytes in culture [27].

Regulatory relationships of TJP1

  • However, cytochalasin D pretreatment blocks both the EGF-induced ZO-1 rearrangement and tyrosine phosphorylation, suggesting that these responses are dependent on an intact actin microfilament system [28].
  • IGF-I receptor-induced cell-cell adhesion of MCF-7 breast cancer cells requires the expression of junction protein ZO-1 [29].
  • Time-course analysis of IFN-gamma-induced alterations in ZO-1 expression and apical actin perturbation indicated that these two effects were intimately linked and could not be dissociated [30].
  • Activation of PKC by the phorbol ester TPA induced ZO-1 and occludin transcription, whereas PKC inhibition lead to decreased expression levels [31].
  • These effects on ZO-1 expression were blocked by TTX and VIPra and reproduced by VIP [32].

Other interactions of TJP1


Analytical, diagnostic and therapeutic context of TJP1


  1. Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7. Mohandas, T.K., Chen, X.N., Rowe, L.B., Birkenmeier, E.H., Fanning, A.S., Anderson, J.M., Korenberg, J.R. Genomics (1995) [Pubmed]
  2. Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancer cells. Polette, M., Gilles, C., Nawrocki-Raby, B., Lohi, J., Hunziker, W., Foidart, J.M., Birembaut, P. Cancer Res. (2005) [Pubmed]
  3. Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion. Smalley, K.S., Brafford, P., Haass, N.K., Brandner, J.M., Brown, E., Herlyn, M. Am. J. Pathol. (2005) [Pubmed]
  4. A bacterial protease perturbs the paracellular barrier function of transporting epithelial monolayers in culture. Azghani, A.O., Gray, L.D., Johnson, A.R. Infect. Immun. (1993) [Pubmed]
  5. Monocyte infiltration is highly associated with loss of the tight junction protein zonula occludens in HIV-1-associated dementia. Boven, L.A., Middel, J., Verhoef, J., De Groot, C.J., Nottet, H.S. Neuropathol. Appl. Neurobiol. (2000) [Pubmed]
  6. Activity-dependent AIDA-1 nuclear signaling regulates nucleolar numbers and protein synthesis in neurons. Jordan, B.A., Fernholz, B.D., Khatri, L., Ziff, E.B. Nat. Neurosci. (2007) [Pubmed]
  7. Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro. Fasano, A., Fiorentini, C., Donelli, G., Uzzau, S., Kaper, J.B., Margaretten, K., Ding, X., Guandalini, S., Comstock, L., Goldblum, S.E. J. Clin. Invest. (1995) [Pubmed]
  8. Intraepithelial gammadelta(+) Lymphocytes Maintain the Integrity of Intestinal Epithelial Tight Junctions in Response to Infection. Dalton, J.E., Cruickshank, S.M., Egan, C.E., Mears, R., Newton, D.J., Andrew, E.M., Lawrence, B., Howell, G., Else, K.J., Gubbels, M.J., Striepen, B., Smith, J.E., White, S.J., Carding, S.R. Gastroenterology (2006) [Pubmed]
  9. Intestinal infection with Giardia spp. reduces epithelial barrier function in a myosin light chain kinase-dependent fashion. Scott, K.G., Meddings, J.B., Kirk, D.R., Lees-Miller, S.P., Buret, A.G. Gastroenterology (2002) [Pubmed]
  10. Host-dependent zonulin secretion causes the impairment of the small intestine barrier function after bacterial exposure. El Asmar, R., Panigrahi, P., Bamford, P., Berti, I., Not, T., Coppa, G.V., Catassi, C., Fasano, A., El Asmar, R. Gastroenterology (2002) [Pubmed]
  11. Loss of the tight junction protein claudin 4 correlates with histological growth-pattern and differentiation in advanced gastric adenocarcinoma. Lee, S.K., Moon, J., Park, S.W., Song, S.Y., Chung, J.B., Kang, J.K. Oncol. Rep. (2005) [Pubmed]
  12. Redifferentiation and ZO-1 reexpression in liver-metastasized colorectal cancer: possible association with epidermal growth factor receptor-induced tyrosine phosphorylation of ZO-1. Kaihara, T., Kawamata, H., Imura, J., Fujii, S., Kitajima, K., Omotehara, F., Maeda, N., Nakamura, T., Fujimori, T. Cancer Sci. (2003) [Pubmed]
  13. Histamine alters gene expression in cultured human nasal epithelial cells. Takeuchi, K., Kishioka, C., Ishinaga, H., Sakakura, Y., Majima, Y. J. Allergy Clin. Immunol. (2001) [Pubmed]
  14. Assembly and sealing of tight junctions: possible participation of G-proteins, phospholipase C, protein kinase C and calmodulin. Balda, M.S., González-Mariscal, L., Contreras, R.G., Macias-Silva, M., Torres-Marquez, M.E., García-Sáinz, J.A., Cereijido, M. J. Membr. Biol. (1991) [Pubmed]
  15. Tight junction development between cultured hepatoma cells: possible stages in assembly and enhancement with dexamethasone. Porvaznik, M., Johnson, R.G., Sheridan, J.D. J. Supramol. Struct. (1979) [Pubmed]
  16. The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1. Huber, T.B., Schmidts, M., Gerke, P., Schermer, B., Zahn, A., Hartleben, B., Sellin, L., Walz, G., Benzing, T. J. Biol. Chem. (2003) [Pubmed]
  17. Zonula occludens-1 function in the assembly of tight junctions in Madin-Darby canine kidney epithelial cells. McNeil, E., Capaldo, C.T., Macara, I.G. Mol. Biol. Cell (2006) [Pubmed]
  18. Association of ARVCF with zonula occludens (ZO)-1 and ZO-2: binding to PDZ-domain proteins and cell-cell adhesion regulate plasma membrane and nuclear localization of ARVCF. Kausalya, P.J., Phua, D.C., Hunziker, W. Mol. Biol. Cell (2004) [Pubmed]
  19. Dimerization of the scaffolding protein ZO-1 through the second PDZ domain. Utepbergenov, D.I., Fanning, A.S., Anderson, J.M. J. Biol. Chem. (2006) [Pubmed]
  20. Cortactin associates with the cell-cell junction protein ZO-1 in both Drosophila and mouse. Katsube, T., Takahisa, M., Ueda, R., Hashimoto, N., Kobayashi, M., Togashi, S. J. Biol. Chem. (1998) [Pubmed]
  21. Interaction between the transforming growth factor-beta type II receptor/Smad pathway and beta-catenin during transforming growth factor-beta1-mediated adherens junction disassembly. Tian, Y.C., Phillips, A.O. Am. J. Pathol. (2002) [Pubmed]
  22. Tyrosine phosphorylation and dissociation of occludin-ZO-1 and E-cadherin-beta-catenin complexes from the cytoskeleton by oxidative stress. Rao, R.K., Basuroy, S., Rao, V.U., Karnaky Jr, K.J., Gupta, A. Biochem. J. (2002) [Pubmed]
  23. ZO-3, a novel member of the MAGUK protein family found at the tight junction, interacts with ZO-1 and occludin. Haskins, J., Gu, L., Wittchen, E.S., Hibbard, J., Stevenson, B.R. J. Cell Biol. (1998) [Pubmed]
  24. Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1. Wagner, M.C., Rhodes, G., Wang, E., Pruthi, V., Arif, E., Saleem, M.A., Wean, S.E., Garg, P., Verma, R., Holzman, L.B., Gattone, V., Molitoris, B.A., Nihalani, D. J. Biol. Chem. (2008) [Pubmed]
  25. Influence of retinoic acid on adhesion complexes in human hepatoma cells: a clue to its antiproliferative effects. Ara, C., Devirgiliis, L.C., Massimi, M. Cell Commun. Adhes. (2004) [Pubmed]
  26. Dynamin II interacts with the cadherin- and occludin-based protein complexes at the blood-testis barrier in adult rat testes. Lie, P.P., Xia, W., Wang, C.Q., Mruk, D.D., Yan, H.H., Wong, C.H., Lee, W.M., Cheng, C.Y. J. Endocrinol. (2006) [Pubmed]
  27. Canonical transient receptor potential channel 4 (TRPC4) co-localizes with the scaffolding protein ZO-1 in human fetal astrocytes in culture. Song, X., Zhao, Y., Narcisse, L., Duffy, H., Kress, Y., Lee, S., Brosnan, C.F. Glia (2005) [Pubmed]
  28. Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells. Van Itallie, C.M., Balda, M.S., Anderson, J.M. J. Cell. Sci. (1995) [Pubmed]
  29. IGF-I receptor-induced cell-cell adhesion of MCF-7 breast cancer cells requires the expression of junction protein ZO-1. Mauro, L., Bartucci, M., Morelli, C., Ando', S., Surmacz, E. J. Biol. Chem. (2001) [Pubmed]
  30. Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin. Youakim, A., Ahdieh, M. Am. J. Physiol. (1999) [Pubmed]
  31. Influence of protein kinase C on transcription of the tight junction elements ZO-1 and occludin. Weiler, F., Marbe, T., Scheppach, W., Schauber, J. J. Cell. Physiol. (2005) [Pubmed]
  32. Human ENS regulates the intestinal epithelial barrier permeability and a tight junction-associated protein ZO-1 via VIPergic pathways. Neunlist, M., Toumi, F., Oreschkova, T., Denis, M., Leborgne, J., Laboisse, C.L., Galmiche, J.P., Jarry, A. Am. J. Physiol. Gastrointest. Liver Physiol. (2003) [Pubmed]
  33. Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling. Pálmer, H.G., González-Sancho, J.M., Espada, J., Berciano, M.T., Puig, I., Baulida, J., Quintanilla, M., Cano, A., de Herreros, A.G., Lafarga, M., Muñoz, A. J. Cell Biol. (2001) [Pubmed]
  34. The HIV protease inhibitors saquinavir, ritonavir, and nelfinavir induce apoptosis and decrease barrier function in human intestinal epithelial cells. Bode, H., Lenzner, L., Kraemer, O.H., Kroesen, A.J., Bendfeldt, K., Schulzke, J.D., Fromm, M., Stoltenburg-Didinger, G., Zeitz, M., Ullrich, R. Antivir. Ther. (Lond.) (2005) [Pubmed]
  35. Junctional adhesion molecule interacts with the PDZ domain-containing proteins AF-6 and ZO-1. Ebnet, K., Schulz, C.U., Meyer Zu Brickwedde, M.K., Pendl, G.G., Vestweber, D. J. Biol. Chem. (2000) [Pubmed]
  36. Molecular cloning, functional expression, and tissue distribution of a novel human gap junction-forming protein, connexin-31.9. Interaction with zona occludens protein-1. Nielsen, P.A., Beahm, D.L., Giepmans, B.N., Baruch, A., Hall, J.E., Kumar, N.M. J. Biol. Chem. (2002) [Pubmed]
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