The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PER3  -  period circadian clock 3

Homo sapiens

Synonyms: Cell growth-inhibiting gene 13 protein, Circadian clock protein PERIOD 3, GIG13, Period circadian protein homolog 3, hPER3
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PER3


Psychiatry related information on PER3

  • However, the trends for ARNTL and PER3 are suggestive of their involvement in bipolar disorder and warrant further study in a larger sample [3].
  • The data show that this polymorphism in PER3 predicts individual differences in the sleep-loss-induced decrement in performance and that this differential susceptibility may be mediated by its effects on sleep homeostasis [4].

High impact information on PER3


Biological context of PER3


Other interactions of PER3

  • Genetic variations within the human PER2 and PER3 genes have been linked with diurnal preference and disorders of sleep timing [11].


  1. Genetics of the sleep-wake cycle and its disorders. Hamet, P., Tremblay, J. Metab. Clin. Exp. (2006) [Pubmed]
  2. Period3 structural variation: a circadian biomarker associated with breast cancer in young women. Zhu, Y., Brown, H.N., Zhang, Y., Stevens, R.G., Zheng, T. Cancer Epidemiol. Biomarkers Prev. (2005) [Pubmed]
  3. Suggestive evidence for association of the circadian genes PERIOD3 and ARNTL with bipolar disorder. Nievergelt, C.M., Kripke, D.F., Barrett, T.B., Burg, E., Remick, R.A., Sadovnick, A.D., McElroy, S.L., Keck, P.E., Schork, N.J., Kelsoe, J.R. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2006) [Pubmed]
  4. PER3 polymorphism predicts sleep structure and waking performance. Viola, A.U., Archer, S.N., James, L.M., Groeger, J.A., Lo, J.C., Skene, D.J., von Schantz, M., Dijk, D.J. Curr. Biol. (2007) [Pubmed]
  5. Correlative association between N-methyl-D-aspartate receptor-mediated expression of period genes in the suprachiasmatic nucleus and phase shifts in behavior with photic entrainment of clock in hamsters. Moriya, T., Horikawa, K., Akiyama, M., Shibata, S. Mol. Pharmacol. (2000) [Pubmed]
  6. Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers. Chen, S.T., Choo, K.B., Hou, M.F., Yeh, K.T., Kuo, S.J., Chang, J.G. Carcinogenesis (2005) [Pubmed]
  7. Association of the length polymorphism in the human Per3 gene with the delayed sleep-phase syndrome: does latitude have an influence upon it? Pereira, D.S., Tufik, S., Louzada, F.M., Benedito-Silva, A.A., Lopez, A.R., Lemos, N.A., Korczak, A.L., D'Almeida, V., Pedrazzoli, M. Sleep. (2005) [Pubmed]
  8. Transcriptional activation of the neuronal peripherin-encoding gene depends on a G + C-rich element that binds Sp1 in vitro and in vivo. Ferrari, N., Desmarais, D., Royal, A. Gene (1995) [Pubmed]
  9. Evolution of a length polymorphism in the human PER3 gene, a component of the circadian system. Nadkarni, N.A., Weale, M.E., von Schantz, M., Thomas, M.G. J. Biol. Rhythms (2005) [Pubmed]
  10. Using Per gene expression to search for photoperiodic oscillators in the hamster suprachiasmatic nucleus. de la Iglesia, H.O., Meyer, J., Schwartz, W.J. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  11. A silent polymorphism in the PER1 gene associates with extreme diurnal preference in humans. Carpen, J.D., von Schantz, M., Smits, M., Skene, D.J., Archer, S.N. J. Hum. Genet. (2006) [Pubmed]
WikiGenes - Universities