The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tek  -  TEK tyrosine kinase, endothelial

Rattus norvegicus

Synonyms: Tie-2, Tie2
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tek


High impact information on Tek

  • These data demonstrate a role for the Tie2 pathway in pathologic angiogenesis, suggesting that targeting this pathway may yield effective antiangiogenic agents for treatment of cancer and other angiogenic diseases [6].
  • Tie2 is a novel receptor tyrosine kinase that is expressed almost exclusively by vascular endothelium [6].
  • The effects of the drugs were evaluated by morphometric assessment of endothelial cell injury in H&E, trypan blue, and immunostained (TIE2/Tek) biopsy specimens [7].
  • Tie2 (a.k.a Tek) is an endothelium-specific receptor tyrosine kinase known to play a role in tumor angiogenesis [8].
  • Surprisingly, however, unlike Tie2-null mutant mice, mice deficient in signaling through this tyrosine residue show a normal association of perivascular cells with nascent blood vessels [9].

Chemical compound and disease context of Tek


Biological context of Tek


Anatomical context of Tek


Associations of Tek with chemical compounds


Regulatory relationships of Tek


Other interactions of Tek


Analytical, diagnostic and therapeutic context of Tek


  1. Alterations in expression of angiopoietins and the Tie-2 receptor in the retina of streptozotocin induced diabetic rats. Ohashi, H., Takagi, H., Koyama, S., Oh, H., Watanabe, D., Antonetti, D.A., Matsubara, T., Nagai, K., Arai, H., Kita, T., Honda, Y. Mol. Vis. (2004) [Pubmed]
  2. Enhanced expression of angiopoietin-2 and the Tie2 receptor but not angiopoietin-1 or the Tie1 receptor in a rat model of myocardial infarction. Shyu, K.G., Liang, Y.J., Chang, H., Wang, B.W., Leu, J.G., Kuan, P. J. Biomed. Sci. (2004) [Pubmed]
  3. Induction of Tie-1 and Tie-2 receptor protein expression after cerebral ischemia-reperfusion. Lin, T.N., Nian, G.M., Chen, S.F., Cheung, W.M., Chang, C., Lin, W.C., Hsu, C.Y. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  4. Differential expression of Tie-2 receptors and angiopoietins in response to in vivo hypoxia in rats. Abdulmalek, K., Ashur, F., Ezer, N., Ye, F., Magder, S., Hussain, S.N. Am. J. Physiol. Lung Cell Mol. Physiol. (2001) [Pubmed]
  5. Angiopoietin-1 promotes neurite outgrowth from dorsal root ganglion cells positive for Tie-2 receptor. Kosacka, J., Figiel, M., Engele, J., Hilbig, H., Majewski, M., Spanel-Borowski, K. Cell Tissue Res. (2005) [Pubmed]
  6. Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth. Lin, P., Polverini, P., Dewhirst, M., Shan, S., Rao, P.S., Peters, K. J. Clin. Invest. (1997) [Pubmed]
  7. Antiangiogenic agents protect liver sinusoidal lining cells from cold preservation injury in rat liver transplantation. Gao, W., Washington, M.K., Bentley, R.C., Clavien, P.A. Gastroenterology (1997) [Pubmed]
  8. Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. Lin, P., Buxton, J.A., Acheson, A., Radziejewski, C., Maisonpierre, P.C., Yancopoulos, G.D., Channon, K.M., Hale, L.P., Dewhirst, M.W., George, S.E., Peters, K.G. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  9. Selective role of a distinct tyrosine residue on Tie2 in heart development and early hematopoiesis. Tachibana, K., Jones, N., Dumont, D.J., Puri, M.C., Bernstein, A. Mol. Cell. Biol. (2005) [Pubmed]
  10. Expression of Tie-2 and angiopoietin-1 and -2 in early phase of ulcer healing. Wen, C.Y., Ito, M., Chen, L.D., Matsuu, M., Shichijo, K., Nakayama, T., Nakashima, M., Xu, Z.M., Ohtsuru, A., Hsu, C.T., Sekine, I. J. Gastroenterol. (2003) [Pubmed]
  11. Reciprocal regulation of angiopoietin-1 and angiopoietin-2 following myocardial infarction in the rat. Sandhu, R., Teichert-Kuliszewska, K., Nag, S., Proteau, G., Robb, M.J., Campbell, A.I., Kuliszewski, M.A., Kutryk, M.J., Stewart, D.J. Cardiovasc. Res. (2004) [Pubmed]
  12. A pericyte-derived angiopoietin-1 multimeric complex induces occludin gene expression in brain capillary endothelial cells through Tie-2 activation in vitro. Hori, S., Ohtsuki, S., Hosoya, K., Nakashima, E., Terasaki, T. J. Neurochem. (2004) [Pubmed]
  13. Tyrosine phosphatase inhibition augments collateral blood flow in a rat model of peripheral vascular disease. Carr, A.N., Davis, M.G., Eby-Wilkens, E., Howard, B.W., Towne, B.A., Dufresne, T.E., Peters, K.G. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  14. Protective role of angiopoietin-1 in experimental pulmonary hypertension. Zhao, Y.D., Campbell, A.I., Robb, M., Ng, D., Stewart, D.J. Circ. Res. (2003) [Pubmed]
  15. Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells. Zheng, W., Christensen, L.P., Tomanek, R.J. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  16. Increased expression of angiopoietin-2 and Tie2 receptor in a rat model of myocardial ischaemia/reperfusion. Shyu, K.G., Chang, C.C., Wang, B.W., Kuan, P., Chang, H. Clin. Sci. (2003) [Pubmed]
  17. Induction of functional neovascularization by combined VEGF and angiopoietin-1 gene transfer using AAV vectors. Arsic, N., Zentilin, L., Zacchigna, S., Santoro, D., Stanta, G., Salvi, A., Sinagra, G., Giacca, M. Mol. Ther. (2003) [Pubmed]
  18. Retinal angiogenesis is mediated by an interaction between the angiotensin type 2 receptor, VEGF, and angiopoietin. Sarlos, S., Rizkalla, B., Moravski, C.J., Cao, Z., Cooper, M.E., Wilkinson-Berka, J.L. Am. J. Pathol. (2003) [Pubmed]
  19. Angiotensin II induces expression of the Tie2 receptor ligand, angiopoietin-2, in bovine retinal endothelial cells. Otani, A., Takagi, H., Oh, H., Koyama, S., Honda, Y. Diabetes (2001) [Pubmed]
  20. Tie-2 and angiopoietin-1 expression in human thyroid tumors. Mitsutake, N., Namba, H., Takahara, K., Ishigaki, K., Ishigaki, J., Ayabe, H., Yamashita, S. Thyroid (2002) [Pubmed]
  21. Regulation of angiopoietin and Tie-2 receptor expression in non-reproductive tissues by estrogen. Ye, F., Florian, M., Magder, S.A., Hussain, S.N. Steroids (2002) [Pubmed]
  22. Temporal renal expression of angiogenic growth factors and their receptors in experimental diabetes: role of the renin-angiotensin system. Rizkalla, B., Forbes, J.M., Cao, Z., Boner, G., Cooper, M.E. J. Hypertens. (2005) [Pubmed]
  23. DITPA stimulates bFGF, VEGF, angiopoietin, and Tie-2 and facilitates coronary arteriolar growth. Wang, X., Zheng, W., Christensen, L.P., Tomanek, R.J. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  24. Nitric oxide regulates Angiopoietin1/Tie2 expression after stroke. Zacharek, A., Chen, J., Zhang, C., Cui, X., Roberts, C., Jiang, H., Teng, H., Chopp, M. Neurosci. Lett. (2006) [Pubmed]
  25. Beta IV tubulin is selectively expressed by oligodendrocytes in the central nervous system. Terada, N., Kidd, G.J., Kinter, M., Bjartmar, C., Moran-Jones, K., Trapp, B.D. Glia (2005) [Pubmed]
  26. Tie2 receptor expression is stimulated by hypoxia and proinflammatory cytokines in human endothelial cells. Willam, C., Koehne, P., Jürgensen, J.S., Gräfe, M., Wagner, K.D., Bachmann, S., Frei, U., Eckardt, K.U. Circ. Res. (2000) [Pubmed]
WikiGenes - Universities