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Gene Review

adk  -  adenylate kinase

Escherichia coli O157:H7 str. Sakai

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Disease relevance of adk

  • This seems to indicate that the "loosening" of the three-dimensional structure of E. coli adenylate kinase by proline----serine substitution is largely compensated for when an enzyme X ATP or enzyme X Ap5A complex is formed [1].
  • In this work, we identified and characterized the adenylate kinase activity in extracts from the flagellated parasite Trypanosoma cruzi, the causative agent of Chagas' disease [2].

High impact information on adk


Chemical compound and disease context of adk

  • Previous genetic and biochemical experiments have suggested that the adenylate kinase of Escherichia coli may be directly involved in phospholipid synthesis through formation of a complex with sn-glycerol-3-phosphate acyltransferase, the membrane-bound enzyme that catalyzes the first step in phospholipid synthesis [4].

Anatomical context of adk


Analytical, diagnostic and therapeutic context of adk


  1. Substitution of a serine residue for proline-87 reduces catalytic activity and increases susceptibility to proteolysis of Escherichia coli adenylate kinase. Gilles, A.M., Saint-Girons, I., Monnot, M., Fermandjian, S., Michelson, S., Bârzu, O. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  2. An expanded adenylate kinase gene family in the protozoan parasite Trypanosoma cruzi. Bouvier, L.A., Miranda, M.R., Canepa, G.E., Alves, M.J., Pereira, C.A. Biochim. Biophys. Acta (2006) [Pubmed]
  3. Inactivation and proteolysis of heat-sensitive adenylate kinase of Escherichia coli CR341 T28. Guiso, N., Michelson, S., Bârzu, O. J. Biol. Chem. (1984) [Pubmed]
  4. Adenylate kinase of Escherichia coli: evidence for a functional interaction in phospholipid synthesis. Goelz, S.E., Cronan, J.E. Biochemistry (1982) [Pubmed]
  5. Intracellular localization of ATP:AMP phosphotransferase in Escherichia coli. Watanabe, K., Fukumoto, H., Isoi, K. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
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